Results 61 to 70 of about 5,284,490 (388)

Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?

Physiological Reviews, 2018
Genomic instability is a primary cause and fundamental feature of human cancer. However, all cancer cell genotypes generally translate into several common pathophysiological features, often referred to as cancer hallmarks.
N. Prevarskaya, R. Skryma, Y. Shuba
semanticscholar   +1 more source

Error correction due to background subtraction in ratiometric calcium measurements with CCD camera

Heliyon, 2020
Background: Ca2+ plays an important role in many physiological processes and an accurate study of these signals is important. In modern fluorescence microscopy, a charge-coupled device (CCD) camera is widely deployed for calcium imaging.
Vyacheslav M. Shkryl
doaj   +1 more source

In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins

Nature Communications, 2022
Photoactivable toxins targeting ion channels have great potential to control cell activity. Here the authors report HwTxIV-Nvoc, a UV light-cleavable and photoactivatable peptide that targets voltage-gated sodium channels; they validate this in cells ...
Jérôme Montnach, Laila Ananda Blömer, Ludivine Lopez, Luiza Filipis, Hervé Meudal, Aude Lafoux, Sébastien Nicolas, Duong Chu, Cécile Caumes, Rémy Béroud, Chris Jopling, Frank Bosmans, Corinne Huchet, Céline Landon, Marco Canepari, Michel De Waard   +15 more
doaj   +1 more source

Episodic neurologic disorders: syndromes, genes, and mechanisms. [PDF]

, 2013
Many neurologic diseases cause discrete episodic impairment in contrast with progressive deterioration. The symptoms of these episodic disorders exhibit striking variety.
Fu, Ying-Hui, Ptáček, Louis J, Russell, Jonathan F   +2 more
core   +2 more sources

OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

bioRxiv, 2018
Mechanotransduction, the conversion of mechanical cues into biochemical signals, is crucial for many biological processes in plants and animals1,2. In mammals, some mechanosensory processes such as touch sensation and vascular development are mediated by
Swetha E. Murthy, A. Dubin, Tess Whitwam, S. Jojoa-Cruz, Stuart M. Cahalan, S. Mosavi, A. Ward, A. Patapoutian   +7 more
semanticscholar   +1 more source

Redox Regulation of Mitochondrial Potassium Channels Activity

Antioxidants
Redox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (
Joanna Lewandowska, Barbara Kalenik, Antoni Wrzosek, Adam Szewczyk   +3 more
doaj   +1 more source

Comparison of Langevin and Markov channel noise models for neuronal signal generation

, 2009
The stochastic opening and closing of voltage-gated ion channels produces noise in neurons. The effect of this noise on the neuronal performance has been modelled using either approximate or Langevin model, based on stochastic differential equations or ...
A. L. Hodgkin, B. Sengupta, C. P. Fall, C. W. Gardiner, E. M. Izhikevich, F. Rieke, G. Marsaglia, J. C. Roddey, J. E. McGeoch, J. E. Niven, J. S. Bendat, P. E. Kloeden, S. B. Laughlin, T. M. Cover, W. Gerstner, W. H. Press   +15 more
core   +1 more source

Human sperm ion channel (dys)function:implications for fertilization [PDF]

, 2019
BACKGROUND: Intensive research on sperm ion channels has identified members of several ion channel families in both mouse and human sperm. Gene knock-out studies have unequivocally demonstrated the importance of the calcium and potassium conductances in ...
Barratt, Christopher L. R., Brown, Sean G., Martins da Silva, Sarah J., Publicover, Stephen J.   +3 more
core   +4 more sources

Cannabinoid interactions with ion channels and receptors

Channels, 2019
Cannabidiol (CBD), the non-psychoactive component of Cannabis sativa, acts on a diverse selection of membrane proteins with promising therapeutic potential in epilepsy and chronic pain. One such protein is the voltage-gated sodium channel (Nav).
Abeline R. Watkins
semanticscholar   +1 more source

TRPM Family Channels in Cancer

Pharmaceuticals, 2018
Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains.
Aline Hantute-Ghesquier, Aurélien Haustrate, Natalia Prevarskaya, V’yacheslav Lehen’kyi   +3 more
doaj   +1 more source