Results 151 to 160 of about 59,355 (255)

Targeting Glutamate Excitotoxicity With Memantine Modulates Glial Response and Protects Motoneurons After Spinal Root Lesion

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Motoneuron axotomy induced marked neuroinflammation, synaptic withdrawal, and structural remodeling in the ventral root crush (VRC) model, characterized by intense microglial and astroglial activation and reduced synaptic coverage. Memantine treatment produced consistent, dose‐dependent neuroprotection, with maximal effects at 45 mg/kg.
Arthur Ventura Martins Leão, Gabriel Gaspar Bíscaro, Alexandre Leite Rodrigues de Oliveira, Luciana Politti Cartarozzi   +3 more
wiley   +1 more source

Efficacy and Safety of Repeated Radiofrequency Thermocoagulation on Trigeminal Neuralgia Patients

Pain Practice, Volume 26, Issue 4, April 2026.
ABSTRACT Background Trigeminal neuralgia (TN) is a pain condition characterized by paroxysmal, electric shock‐like facial pain, affecting one or more areas of the branches. Approximately 33%–50% of patients require invasive treatment. Radiofrequency thermocoagulation (RFTC) is an established method for managing drug‐resistant and chronic TN. This study
Antti J. Luikku, Sara Matikka, Sami Heikkinen, Anssi Lipponen, Katja Luostarinen, Timo Koivisto, Ville Leinonen, Jukka Huttunen, Henna‐Kaisa Jyrkkänen   +8 more
wiley   +1 more source

Isometric handgrip contraction increases tibialis anterior intrinsic motoneuron excitability in a dose‐dependent manner

Experimental Physiology, Volume 111, Issue 4, Page 2200-2213, 1 April 2026.
Abstract The contribution of persistent inward currents (PICs) to motoneuron firing in the lower limb typically increases after a remote handgrip contraction, believed to result from diffuse serotonergic input increases in spinal cord. We investigated whether handgrip contraction intensity, duration and/or impulse would affect PIC estimates in tibialis
Lucas Ugliara, Lucas B. R. Orssatto, Amilton Vieira, Gabriel S. Trajano   +3 more
wiley   +1 more source

Ionotropic Receptor 76b Is Required for Gustatory Aversion to Excessive Na+ in Drosophila. [PDF]

Mol Cells, 2017
Lee MJ, Sung HY, Jo H, Kim HW, Choi MS, Kwon JY, Kang K.   +6 more
europepmc   +1 more source

6‐Methylsulfinylhexyl isothiocyanate activates carbonic anhydrase‐dependent HCO3−/H+/Na+/Ca2+ transport via SLC4As–NHE–NCX–PMCA axis in odontoblasts

The Journal of Physiology, Volume 604, Issue 7, Page 2816-2844, 1 April 2026.
Abstract figure legend 6‐Methylsulfinylhexyl isothiocyanate (6‐MSITC, hexaraphane), a wasabi sulfinyl compound, activates intracellular carbonic anhydrase (CA)‐mediated sequential HCO3−, Na+, H+ and Ca2+ transport through an activation axis involving HCO3−‐transporting solute carrier family 4 (SLC4As), the Na+–H+ exchanger (NHE), the Na+–Ca2+ exchanger
Yoshiaki Furusawa, Maki Kimura, Isao Okunishi, Takehito Ouchi, Ryuya Kurashima, Tomoe Katou‐Yamada, Hidetaka Kuroda, Makoto Sugita, Masahiro Furusawa, Yoshiyuki Shibukawa   +9 more
wiley   +1 more source

Glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) gene polymorphism (rs4998386) and Parkinson's disease susceptibility: A meta-analysis. [PDF]

Aging Med (Milton), 2019
Nepal G, Rehrig JH, Ojha R.
europepmc   +1 more source

The sympathoregulatory region of the mouse rostral brainstem relies on both GABA and glycine to generate inhibitory currents

The Journal of Physiology, Volume 604, Issue 7, Page 2939-2957, 1 April 2026.
Abstract figure legend Our study demonstrates that both GABA and glycine mediate inhibitory postsynaptic currents in the ventrolateral/ventromedial medulla (VLM/VMM) and increasing the activity of inhibitory synapses facilitates glycine release. We found that presympathetic VLM/VMM neurons receive glycinergic inputs, which release both glycine and GABA,
Hong Gao, Lucie D. Desmoulins, Adrien J. R. Molinas, Courtney M. Dugas, Andrea Zsombok, Andrei V. Derbenev   +5 more
wiley   +1 more source

<i>Escherichia coli</i> Mono-Association Modulates Ionotropic Receptor-Dependent Behaviors in <i>Drosophila melanogaster</i>. [PDF]

Insects
Al Darwish H, Cacao M, Hart T, Patel D, Russo S, Salama S, Tariq M, Ananda AT, Sun JS.   +8 more
europepmc   +1 more source

Ca²⁺ flux through splice variants of the ATP-gated ionotropic receptor P2X7 is regulated by its cytoplasmic N terminus. [PDF]

J Biol Chem, 2019
Liang X, Samways DSK, Cox J, Egan TM.
europepmc   +1 more source

Pharmacological manipulation of the immediate effects of spinal trauma in neonatal rats reveals a crucial role for TRPV4 receptors

The Journal of Physiology, Volume 604, Issue 7, Page 3077-3093, 1 April 2026.
Abstract figure legend A, schematic illustration of the ventral aspect of an ex vivo preparation of the entire CNS from a neonatal rat subjected to a calibrated thoracic impact. The trauma induced a large depolarising injury potential (DIP, black trace) recorded from the L5 ventral root (VRrL5), which was markedly reduced by transient receptor ...
Atiyeh Mohammadshirazi, Caterina Ciani, Francesca Emma Mongelli, Rashid Giniatullin, Carmen Falcone, Giuliano Taccola   +5 more
wiley   +1 more source