Results 151 to 160 of about 35,320 (207)
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Mammalian ionotropic glutamate receptors
Current Opinion in Neurobiology, 1993Exciting new milestones in glutamate receptor (GluR) channel research include the following: the cloning of N-methyl-D-aspartate (NMDA) receptors; delineation of molecular determinants for ion flow through glutamate-gated channels; the discovery that Ca2+ permeability of non-NMDA receptor channels is determined by RNA editing; the construction of ...
Wisden, W., Seeburg, P.
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Ionotropic glutamate receptors
Current Opinion in Chemical Biology, 1999The glutamate-binding sites of ionotropic glutamate receptors are formed from two extracellular domains of a single subunit. Conformational changes induced by agonist binding produce mechanical processes that are translated into ion gating and receptor desensitization.
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Purine Ionotropic (P2X) Receptors
Current Pharmaceutical Design, 2007Purinergic signaling is involved in the proper functioning of virtually all organs of the body. Although in some cases purines have a major influence on physiological functions (e.g. thrombocyte aggregation), more often they are just background modulators contributing to fine tuning of biological events.
L, Köles, S, Fürst, P, Illes
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Candidate chemosensory ionotropic receptors in a Lepidoptera
Insect Molecular Biology, 2010Abstract A new family of candidate chemosensory ionotropic receptors (IRs) related to ionotropic glutamate receptors (iGluRs) was recently discovered in Drosophila melanogaster .
Olivier, Violaine +4 more
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Presynaptic Ionotropic GABA Receptors
2007Following the classical work on presynaptic inhibition in the spinal cord, recent work has revealed an astonishing abundance and diversity of presynaptic ionotropic GABA receptors. While modern techniques allow for detailed studies at the cellular and molecular level in almost all regions of the CNS, our understanding of the function of such receptors ...
Andreas, Draguhn +2 more
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Glycine agonism in ionotropic glutamate receptors
Neuropharmacology, 2021Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the majority of excitatory neurotransmission in the vertebrate CNS. Classified as AMPA, kainate, delta and NMDA receptors, iGluRs are central drivers of synaptic plasticity widely considered as a major cellular substrate of learning and memory. Surprisingly however, five
Stroebel, David +2 more
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Molecular Structure of Ionotropic Glutamate Receptors
Current Medicinal Chemistry, 2010L-glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). Although just a few glutamate receptor ligands have turned out to be clinically useful, primarily because of unfavorable psychotropic side effects, the glutamate system remains an attractive molecular target in the treatment of epilepsy, neurodegenerative diseases
A A, Kaczor, D, Matosiuk
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Monoamine Transporters as Ionotropic Receptors
Trends in Neurosciences, 2017It is well established that glutamate and GABA signal through both ionotropic and metabotropic receptors. Conversely, it is thought that, with one exception, monoamines (dopamine, serotonin, and norepinephrine) signal via metabotropic receptors. Given their capacity to generate fast-acting currents, I suggest that the monoamine transporters should be ...
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The subunit arrangement and assembly of ionotropic receptors
Trends in Neurosciences, 2008Ionotropic receptors mediate rapid communication between neurons. These receptors are oligomers and are usually assembled from multiple subunit types. Receptors built from different subunit combinations have distinct functional properties, such as single-channel conductances, rates of desensitization and sensitivities to activators and inactivators ...
Nelson P, Barrera, J Michael, Edwardson
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Ionotropic Glutamate Receptors
2013On this planet, the mammalian brain is probably the most complex cellular network. In this system, glutamate is the dominant neurotransmitter, and it mediates the fast communication between the units of the network. Glutamate's main sites of action are the ionotropic glutamate receptors (iGluRs) and G−protein−coupled metabotropic glutamate receptors ...
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