Results 61 to 70 of about 41,736 (257)
Ca2+-Dependent Inositol 1,4,5-Trisphosphate and Nitric Oxide Signaling in Cerebellar Neurons
Journal of Pharmacological Sciences, 2006 .: Intracellular Ca2+ signals are important for the regulation of synaptic functions in the central nervous system. In this review, I summarize findings of our recent studies on upstream and downstream Ca2+ signaling mechanisms in cerebellar synapses ...
Masamitsu Iino
doaj +1 more source
Spatial-temporal patterning of Ca2+ signals by the subcellular distribution of IP3 and IP3 receptors
Seminars in Cell & Developmental Biology, 2019 The patterning of cytosolic Ca2+ signals in space and time underlies their ubiquitous ability to specifically regulate numerous cellular processes. Signals mediated by liberation of Ca2+ sequestered in the endoplasmic reticulum (ER) through inositol trisphosphate receptor (IP3R) channels constitute a hierarchy of events; ranging from openings of ...
Lock, Jeffrey T +2 more
openaire +5 more sources
Business Strategy and the Environment, EarlyView.ABSTRACT In a macroeconomic environment characterised by systemic disruptions and global uncertainty, companies are forced to reconfigure their sustainability strategies. This study examines the combined impact of geopolitical and climate risks on corporate commitment to and actual progress toward the United Nations (UN) Sustainable Development Goals ...
Isabel‐María García‐Sánchez
wiley +1 more source
Communicative & Integrative Biology, 2010 Autosomal dominant polycystic kidney disease (ADPKD) arises as a consequence of mutations of the genes PKD1 and PKD2, encoding respectively the integral membrane proteins polycystin-1 and polycystin-2 (TRPP2), resulting in a disturbance in intracellular ...
Eva Sammels +6 more
doaj +1 more source
Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT Employee sustainability teams—groups collaborating continuously and voluntarily on sustainability initiatives—can serve as a bottom‐up driver for organizational change. Despite their potential, however, their role and contributions are underexplored. To fill this gap, our multi‐case study examines 59 projects by 13 teams across three companies
Jennifer Adolph +3 more
wiley +1 more source
International Journal of Mechanical System Dynamics, EarlyView.ABSTRACT The rotor system of an electrically assisted turbocharger (EAT) is composed of multiple shaft components; The nonlinear connection and contact effects make it difficult to determine the system dynamic characteristics. To improve the modeling accuracy of EAT rotor system and evaluate the influence of contact between multi‐axis components and ...
Wenchao Liang +5 more
wiley +1 more source
Subcellular Mechanisms of Presenilin-Mediated Enhancement of Calcium Signaling
Neurobiology of Disease, 2001 Mutations in presenilin-1 (PS1), the leading cause of early-onset, autosomal-dominant familial Alzheimer's disease (FAD), enhance calcium signaling mediated by inositol 1,4,5-trisphosphate (IP3).
Malcolm A. Leissring +3 more
doaj +1 more source
Structural basis for activation and gating of IP3 receptors
Nature Communications, 2022 IP3 receptors are intracellular calcium channels involved in numerous signaling pathways. Here, the authors present the cryo-EM structures of type-3 IP3 receptors in multiple gating conformations, including the active state revealing the molecular ...
Emily A. Schmitz +2 more
doaj +1 more source
Neuroprotection, EarlyView.Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu +7 more
wiley +1 more source
IP3 -Progress towards a Global ICT Profession [PDF]
, 2020 . The International Professional Practice Partnership (IP3) was formed by the International Federation for Information processing (IFIP) in 2007 to fulfill the objective of creating a global ICT profession.
Roger G Johnson
core