Results 71 to 80 of about 41,736 (257)
Cellular and Molecular Life SciencesInositol 1,4,5-trisphosphate (IP3) receptor channels are intracellular ion channels activated by IP3 and provoking Ca2+ release from ER/SR stores, playing fundamental roles in various cell functions ranging from fertilization up to cell death control ...
Katja Witschas, Siyu Tao, Luc Leybaert
doaj +1 more source
MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis
Stem Cell Reports, 2019 Summary: Physical exercise stimulates adult hippocampal neurogenesis and is considered a relevant strategy for preventing age-related cognitive decline in humans. The underlying mechanisms remains controversial.
Meritxell Pons-Espinal +10 more
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Phytotherapy Research, EarlyView.Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng +6 more
wiley +1 more source
Taste‐Active Peptides: Sensation Mechanisms and Structure–Taste Relationships
Sensory Neuroscience, EarlyView.Overview of taste‐active peptides, including taste bud cellular organization, peptide–receptor interactions and signaling pathways, structure–taste relationships, and integrated computational and experimental strategies for peptide discovery, mechanism elucidation, and flavor modulation.
Dengyi Pei +4 more
wiley +1 more source
Cyclic AMP Recruits a Discrete Intracellular Ca2+ Store by Unmasking Hypersensitive IP3 Receptors
Cell Reports, 2017 Inositol 1,4,5-trisphosphate (IP3) stimulates Ca2+ release from the endoplasmic reticulum (ER), and the response is potentiated by 3′,5′-cyclic AMP (cAMP).
Vera Konieczny +4 more
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Sensory Neuroscience, EarlyView.This study investigated vestibular function in 129 adult patients with inner ear malformations (IEMs). The superior semicircular canal showed less impairment than the horizontal and posterior canals. Notably, cochlear implantation did not significantly exacerbate vestibular dysfunction at 12 months postoperatively.
Ruijie Wang +5 more
wiley +1 more source
Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes. [PDF]
PLoS ONE, 2014 Inositol 1,4,5-trisphosphate (IP3) evokes release of Ca2+ from the endoplasmic reticulum (ER), but the resulting Ca2+ signals are shaped by interactions with additional intracellular organelles.
Cristina I López Sanjurjo +2 more
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Integrative Zoology, EarlyView.This study integrates genomics and landscape genetics to analyze African goat environmental adaptation. Analyzing 1591 samples, it finds population structure differentiates geographically into four groups, with gene flow between wild Yura goats and North Africans.
Weifeng Peng +19 more
wiley +1 more source
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
A quad‐cistronic fluorescent biosensor system for real‐time detection of subcellular Ca2+ signals
British Journal of Pharmacology, EarlyView.Background and Purpose The calcium ion (Ca2+) is a versatile cellular messenger regulating a variety of biological processes. Compounds modulating subcellular Ca2+ signals hold substantial pharmacological potential. Advances in fluorescent biosensors have revolutionised Ca2+ imaging.
Anna Lischnig +7 more
wiley +1 more source