Saturated fatty acids differently affect mitochondrial function and the intestinal epithelial barrier depending on their chain length in the in vitro model of IPEC-J2 enterocytes. [PDF]
Front Cell Dev BiolGuerbette T +7 more
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Porcine IPEC-J2 intestinal epithelial cells in microbiological investigations [PDF]
Veterinary Microbiology, 2012 IPEC-J2 cells are porcine intestinal columnar epithelial cells that were isolated from neonatal piglet mid-jejunum. This cell line forms polarized monolayers with high transepithelial electrical resistance when cultured on 0.4 μm pore-size filters. The cell line is unique in that it is derived from small intestinal tissue (compared to the common human ...
David R Brown, Amanda J Brosnahan
exaly +3 more sources
Relationship between serum concentration, functional parameters and cell bioenergetics in IPEC-J2 cell line [PDF]
Histochemistry and Cell Biology, 2021 The foetal bovine serum (FBS) concentration could influence functional parameters of IPEC-J2 cells. IPEC-J2 is a non-transformed continuous epithelial cell line that represents an established in vitro model to study porcine gut inflammation and ...
Salvatore Nesci +2 more
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Effects of TLR9/NF-κB on oxidative stress and inflammation in IPEC-J2 cells
Genes & Genomics, 2022Oxidative stress is one of the most important factors affecting large-scale breeding, especially the performance of pigs. Oxidative stress plays a role by affecting various genes in pigs, which can cause serious body damage, functional degradation and reduce production performance.The purpose of this study was to investigate the effect of Toll like ...
Lixia Ma +5 more
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The Effects of Lauric Acid on IPEC-J2 Cell Differentiation, Proliferation, and Death
Current Molecular Medicine, 2020Background: Lauric acid (LA) has antimicrobial effects and the potential to replace antibiotics in feeds to prevent postweaning diarrhea and increase overall swine productivity. The effects of lauric acid on the intestinal epithelial cells remain unclear.
Yuan, Yang +4 more
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Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production
Environmental Pollution, 2019Deoxynivalenol (DON) frequently detected in a wide range of foods and feeds, inducing cytotoxicity to animals and humans. To investigate the underlying mechanism of DON-induced apoptosis and inflammation in porcine small intestinal epithelium, intestinal porcine epithelial cells (IPEC-J2 cells) were chosen as objects, and were treated by different ...
Yansen Li
exaly +3 more sources
Transcriptional profiling of zearalenone-induced inhibition of IPEC-J2 cell proliferation
Toxicon, 2019Mounting evidence has shown that zearalenone (ZEA) can have toxic effects on the intestinal epithelial cells (IECs) of mammals and humans, but the mechanism of ZEA-induced toxicity on IECs is unclear. The aim of this study was to reveal the mechanism of action of ZEA on intestinal epithelial cells via RNA-seq technology.
Yongfeng Zhou, Hao Yu, Yong-Cheng Jin
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Expression of Selenoprotein Genes Is Affected by Heat Stress in IPEC-J2 Cells
Biological Trace Element Research, 2015The aim of this study was to explore the impacts of heat stress (HS) on expressions of selenoprotein genes in IPEC-J2 cells. Cells were cultured with 5 % CO2-humidified chamber at 37 °C until the cells grew to complete confluence and then exposed to a mild hyperthermia at 41.5 °C (HS) or 37 °C (control) for another 24 h, finally harvested for total RNA
Lei, Cao +9 more
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