Results 161 to 170 of about 22,373 (186)

Protective Effect of Koumine, an Alkaloid from Gelsemium Sempervirens, on Injury Induced by H2O2 in IPEC-J2 Cells

International Journal of Molecular Sciences, 2019
Medicinal herbal plants have been commonly used for intervention in different diseases and improvement of health worldwide. Koumine, an alkaloid monomer found abundantly in Gelsemium plants, can be effectively used as an antioxidant.
Chenglin Yang, Jing Wu, Yong Wu
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MicroRNA-223 Inhibits Soybean Glycinin- and β-Conglycinin-Induced Apoptosis of IPEC-J2 Cells by Targeting NLRP-3 in the IEL/IPEC-J2 Co-culture System

Journal of Agricultural and Food Chemistry, 2023
The apoptosis of intestinal porcine epithelial cells induced by soybean antigen protein allergy is one of the most important mechanisms responsible for enteritis. MicroRNAs (miRNAs) affect the cellular and physiological functions of all multicellular organisms.
Lei Wang, Zhifeng Sun, Xinggen Shan, Chenglu Peng, Hongyan Ding, Shibin Feng, Chang Zhao, Xichun Wang, Jinjie Wu   +8 more
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Zearalenone induces ROS‐mediated mitochondrial damage in porcine IPEC‐J2 cells

Journal of Biochemical and Molecular Toxicology, 2017
AbstractIn this study, the mitochondrial damage effect and mechanism of zearalenone (ZEA) in swine small intestine IPEC‐J2 cells in vitro were comprehensively characterized. The analyses revealed that ZEA at high doses (8 and 7 μg/mL) can significantly increase P < 0.05 the malondialdehyde levels and decrease antioxidant enzymes activities after 48 ...
Wentao Fan, Tongtong Shen, Qiaoqi Ding, Yanan Lv, Li Li, Kehe Huang, Liping Yan, Suquan Song   +7 more
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The Effects of Butyric Acid on the Differentiation, Proliferation, Apoptosis, and Autophagy of IPEC-J2 Cells

Current Molecular Medicine, 2020
Background: Butyric acid (BT), a short-chain fatty acid, is the preferred colonocyte energy source. The effects of BT on the differentiation, proliferation, and apoptosis of small intestinal epithelial cells of piglets and its underlying mechanisms have not been fully elucidated.
Yuan, Yang, Jin, Huang, Jianzhong, Li, Huansheng, Yang, Yulong, Yin   +4 more
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Protective effects of melatonin on deoxynivalenol-induced oxidative stress and autophagy in IPEC-J2 cells

Food and Chemical Toxicology, 2023
This study explored protective effects of melatonin (MEL) on deoxynivalenol (DON)-induced toxicity in porcine jejunum epithelial cells (IPEC-J2). Cells were preexposed to MEL and then exposed to DON to detect cell viability, apoptosis, and oxidative stress indicators.
Yafei Xu, Yunxiao Xie, Zhengchang Wu, Haifei Wang, Zhenhai Chen, Jingneng Wang, Wenbin Bao   +6 more
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Potassium diformate alleviated inflammation of IPEC-J2 cells infected with EHEC

Veterinary Microbiology
Potassium diformate (KDF) is a kind of formate, which possesses the advantages of antimicrobial activity, growth promotion and preventing diarrhea in weaned piglets. However, the researches of KDF in animal production mostly focused on apparent indexes such as growth performance and the mechanisms of KDF on intestinal health have not been reported ...
Ying, Lin, Jun-Lei, Zhai, Ya-Ting, Wang, Ping-Ting, Guo, Jing, Zhang, Chang-Kang, Wang, Ling, Jin, Yu-Yun, Gao   +7 more
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Transcriptome of IPEC-J2

Following the prohibition of antibiotics in animal feed, the development of novel probiotics has assumed paramount importance. Existing research indicates that Parabacteroides goldsteinii (PG), which was utilized in this experiment, exhibits beneficial probiotic effects in humans.
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Pre-protective effect of lipoic acid on injury induced by H2O2 in IPEC-J2 cells

Molecular and Cellular Biochemistry, 2013
Alpha-lipoic acid (LA) is considered to be a universal antioxidant. The intestine is very sensitive to a wide range of stressors for it exposed in a complex microenvironment that usually contained excess free radicals. The objective of this study was to evaluate the pre-protective effect of LA on intestinal epithelial cell injury induced by H2O2.
Xuan, Cai, Xiaolian, Chen, Xiaochun, Wang, Congcong, Xu, Qi, Guo, Lihui, Zhu, Shuwen, Zhu, Jianxiong, Xu   +7 more
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Fumonisin B1 induces oxidative stress, inflammation and necroptosis in IPEC-J2 cells

Veterinary Research Communications
Fumonisin B1 (FB1), an important mycotoxin, poses a significant threat to public health and livestock production due to its widespread contamination. Furthermore, the gastrointestinal tract is particularly vulnerable to FB1 exposure given its frequent contamination of staple crops such as corn.
Yinuo, Zou, Xinyu, Du, Xiaoyan, Zheng, Sichao, Mao, Xinyi, Xu, Shuxia, Zhang, Xingxiang, Chen   +6 more
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Cytotoxicity and metabolic stress induced by deoxynivalenol in the porcine intestinal IPEC‐J2 cell line

Journal of Animal Physiology and Animal Nutrition, 2011
SummaryThe digestive tract is a target for the Fusarium toxin deoxynivalenol (DON), a major cereal grain contaminant of animal and public health concern. Toxic effects of DON range from diarrhoea, vomiting and gastrointestinal inflammation to necrosis of several tissues.
W A, Awad, J R, Aschenbach, J, Zentek
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