Results 101 to 110 of about 3,566 (193)

Gna11 and Gna14 are expressed in ipRGCs, often in combination.

, 2014
A–E. Representative images of RT-PCR analysis of single ipRGCs for Opn4, Gnaq, Gna11, Gna14, and Gna15. All representative gels show RT-PCR analysis of single ipRGCs taken from P1 Opn4Cre/+; Z/EG mice.
Jeffrey M. Trimarchi (39657), Tiffany M. Schmidt (569265), Paulo Kofuji (569267), Kylie S. Chew (569264), Alan C. Rupp (569266)   +4 more
core   +1 more source

Flp-recombinase mouse line for genetic manipulation of ipRGCs

Abstract Light has myriad impacts on behavior, health, and physiology. These signals originate in the retina and are relayed to the brain by more than 40 types of retinal ganglion cells (RGCs). Despite a growing appreciation for the diversity of RGCs, how these diverse channels of light information are ultimately ...
E Contreras, C Liang, HL Mahoney, JL Javier, ML Luce, K Labastida Medina, T Bozza, TM Schmidt   +7 more
openaire   +2 more sources

Carbenoxolone inhibition of the light-evoked Ca²⁺ response in solitary ipRGCs in vitro is difficult to reverse.

, 2013
Complete Recovery: ipRGCs demonstrating light-evoked Ca2+ responses during carbenoxolone (CBX) washout (45 min) that were ≥100% of the light-evoked Ca2+ response immediately prior to drug treatment were classified as demonstrating complete recovery (n ...
Gary E. Pickard (312753), Erin M. Wiles (346908), Patricia J. Sollars (312752), Jayne R. Bramley (346906)   +3 more
core   +1 more source

Loss of gq/11 genes does not abolish melanopsin phototransduction.

PLoS ONE, 2014
In mammals, a subset of retinal ganglion cells (RGCs) expresses the photopigment melanopsin, which renders them intrinsically photosensitive (ipRGCs). These ipRGCs mediate various non-image-forming visual functions such as circadian photoentrainment and ...
Kylie S Chew, Tiffany M Schmidt, Alan C Rupp, Paulo Kofuji, Jeffrey M Trimarchi   +4 more
doaj   +1 more source

Review on the role of intrinsically photosensitive retinal ganglion cells in the onset and progression of mental disorders

Shanghai Jiaotong Daxue xuebao. Yixue ban
The retina is the peripheral sensor of light information and the only part of the central nervous system accessible to direct observation. It is also regarded as a “window to the brain” due to its developmental and structural similarity to the brain ...
JIA Chenxi, ZHU Jiayi, DU Jiang, ZHAO Min   +3 more
doaj   +1 more source

Taurine Depletion Causes ipRGC Loss and Increases Light-Induced Photoreceptor Degeneration

Investigative Opthalmology & Visual Science, 2018
To examine if light exposure exacerbates retinal neuronal loss induced by taurine depletion.Albino rats received β-alanine in the drinking water to induce taurine depletion. One month later, half of the animals were exposed to white light (3000 lux) continuously for 48 hours and the rest remained in normal environmental conditions.
García-Ayuso, Diego, Pierdomenico, Johnny Di, Hadj-Said, Wahiba, Marie, Mélanie, Agudo-Barriuso, Marta, Vidal-Sanz, Manuel, Picaud, Serge, Villegas-Pérez, María   +7 more
openaire   +3 more sources

Density of melanopsin-positive ipRGCs in the retina of Arvicanthis at different ages.

, 2013
A) Representative photomicrographs showing the change of the density of melanopsin-positive ipRGCs at different stages of the postnatal development. Scale bar: 100 µm.
Diana Karnas (287976), Hilmar Meissl (386310), David Hicks (287980), Paul Pévet (372683), Jérôme Mordel (386308)   +4 more
core   +1 more source

Surprisingly persistent cone-driven response in ipRGCs.

, 2013
Data are from a Cx36 knockout mouse retina, in which the primary and secondary rods paths are eliminated and ON channel synaptic input to ipRGCs comes mainly or exclusively from cones.
Maureen E. Estevez (419500), Shijun Weng (419499), David M. Berson (234821)   +2 more
core   +1 more source

Development of a Smartphone-Based System for Intrinsically Photosensitive Retinal Ganglion Cells Targeted Chromatic Pupillometry

Bioengineering
Chromatic Pupillometry, used to assess Pupil Light Reflex (PLR) to a coloured light stimulus, has regained interest since the discovery of melanopsin in the intrinsically photosensitive Retinal Ganglion Cells (ipRGCs).
Ana Isabel Sousa, Carlos Marques-Neves, Pedro Manuel Vieira   +2 more
doaj   +1 more source

RdgB2 is required for dim-light input into intrinsically photosensitive retinal ganglion cells [PDF]

, 2015
A subset of retinal ganglion cells is intrinsically photosensitive (ipRGCs) and contributes directly to the pupillary light reflex and circadian photoentrainment under bright-light conditions.
Güler, Ali D, Weng, Shijun, Sheng, Wenlong, Walker, Marquis T, Elsaesser, Rebecca, Montell, Craig, Berson, David M, Hattar, Samer, Rupp, Alan   +8 more
core   +1 more source