Results 81 to 90 of about 3,566 (193)
Photochemistry and Photobiology, Volume 102, Issue 4, Page 780-796, July/August 2026.Exposure to artificial light at night (ALAN), particularly at blue wavelengths, disrupts circadian rhythms by suppressing melatonin, thereby increasing cancer susceptibility. This systematic review consolidates evidence linking prolonged ALAN exposure to an elevated risk of breast and prostate tumors.
Gabriel Barboza +4 more
wiley +1 more source
Destruction of ipRGCs by UF008/SAP depends on dose, but not on location within the retina.
, 2013 Ablation of ipRGCs by UF008/SAP is dose-dependent, but not related to retinal eccentricity. Each triplet of bars represents data from “peripheral” (P), ”middle” (M), and “central” (C) fields, respectively. (2-way ANOVA with Bonferroni post-tests).
Keith Studholme (376742) +5 more
core +1 more source
Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.Abstract Glaucoma is a chronic optic neuropathy characterized by progressive vision loss. A previous study from our group showed that glaucoma‐induced retinal degeneration disrupts photic signaling to the suprachiasmatic nucleus (SCN), altering the molecular components of the central circadian clock.
Pietra Souza Barsanele +7 more
wiley +1 more source
Behavioral and Brain Functions, 2010 Background In mammals, the brain clock responsible for generating circadian rhythms is located in the suprachiasmatic nucleus (SCN) of the hypothalamus.
Brown R Lane +3 more
doaj +1 more source
Frontiers in Neuroscience, 2020 Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin and project to central targets, allowing them to contribute to both image-forming and non-image forming vision.
Cyril G. Eleftheriou +5 more
doaj +1 more source
PLoS ONE, 2015 Phosphorylation is a primary modulator of mammalian G-protein coupled receptor (GPCR) activity. The GPCR melanopsin is the photopigment of intrinsically photosensitive retinal ganglion cells (ipRGCs) in the mammalian retina. Recent evidence from in vitro
Timothy J Sexton, Russell N Van Gelder
doaj +1 more source
Synaptic inputs to displaced intrinsically-photosensitive ganglion cells in macaque retina
Scientific Reports, 2022 Ganglion cells are the projection neurons of the retina. Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin and also receive input from rods and cones via bipolar cells and amacrine cells.
Andrea S. Bordt +8 more
doaj +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, Volume 600, Issue 6, Page 837-846, March 2026.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
TeNT expression doesn’t alter ipRGCs responses to light.
, 2016 (A-C) Average ipRGCs responses to 1min light stimulations (480nm) of increasing irradiance (5.1010 photons/cm2/s to 5.1013 photons/cm2/s) recorded from retinas of Opn4cre/+, R26+/+ (A, n = 123), Opn4cre/+, R26+/TeNT (B, n = 87), Opn4cre/+, R26TeNT/TeNT ...
Logan J. Massman (3590501) +5 more
core +1 more source
β-Arrestin-dependent deactivation of mouse melanopsin.
PLoS ONE, 2014 In mammals, the expression of the unusual visual pigment, melanopsin, is restricted to a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs), whose signaling regulate numerous non-visual functions including sleep, circadian ...
Evan G Cameron, Phyllis R Robinson
doaj +1 more source