Results 61 to 70 of about 3,566 (193)

Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits [PDF]

Neuron, 2018
Melanopsin is expressed in distinct types of intrinsically photosensitive retinal ganglion cells (ipRGCs), which drive behaviors from circadian photoentrainment to contrast detection. A major unanswered question is how the same photopigment, melanopsin, influences such vastly different functions.
Sonoda, Takuma, Lee, Seul Ki, Birnbaumer, Lutz, Schmidt, Tiffany M.   +3 more
openaire   +4 more sources

Robust visual cortex evoked potentials (VEP) in Gnat1 and Gnat2 knockout mice

Frontiers in Cellular Neuroscience, 2022
Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin, imparting to themselves the ability to respond to light in the absence of input from rod or cone photoreceptors.
Michael D. Flood, Hannah L. B. Veloz, Samer Hattar, Joao L. Carvalho-de-Souza, Joao L. Carvalho-de-Souza, Joao L. Carvalho-de-Souza, Joao L. Carvalho-de-Souza   +6 more
doaj   +1 more source

Blue Light Exposure During Sleep in Type 1 Diabetes: Impacts on Glycemic Control and Psychosocial Health

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Light exposure at night is linked to increased risk for obesity and insulin resistance in the general population. While sleep health is recognized as a key component of diabetes management, there has been less emphasis on nighttime light exposure. This study aimed to investigate the effects of blue and white light exposure immediately prior to
Seok Jin Hong, Sarida Pratuangtham, Pamela Martyn‐Nemeth, Alana D. Steffen, Chang Gi Park, Sirimon Reutrakul   +5 more
wiley   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, Volume 2, Issue 3, September 2026.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Hyperpolarization-activated current (I(h)) in ganglion-cell photoreceptors.

PLoS ONE, 2010
Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin and serve as the primary retinal drivers of non-image-forming visual functions such as circadian photoentrainment, the pupillary light reflex, and ...
Matthew J Van Hook, David M Berson
doaj   +1 more source

ENLIGHTENme: Translating the Benefits of Self‐Administered Daytime Light Supplementation to Older Adults in the Real World

Journal of Pineal Research, Volume 78, Issue 5, September 2026.
ABSTRACT Controlled studies have demonstrated that light supplementation benefits circadian entrainment, sleep and mood. Translating these findings into effective, real‐world usage of light supplementation is, however, challenging because naturalistic and supplemental light exposure are shaped by personal habits and environmental light conditions ...
Débora B. Constantino, Flavia Baccari, Leonardo Caporali, Valerio Carelli, Giulia Amore, Marijke Gordijn, Toomas Haller, Chiara La Morgia, Anne Landvreugd, Marina Marinelli, David McDaid, Monika Nõmm, Francesco Nonino, Martina Romagnoli, Martino Schettino, Corrado Zenesini, Meike Bartels, Debra J. Skene, Daan R. van der Veen   +18 more
wiley   +1 more source

Melanopsin-Containing ipRGCs Are Resistant to Excitotoxic Injury and Maintain Functional Non-Image Forming Behaviors After Insult in a Diurnal Rodent Model [PDF]

, 2019
Intrinsically photosensitive retinal ganglion cells (ipRGCs) are critical for the light signaling properties of non-image forming vision. Melanopsin-expressing ipRGCs project to retinorecipient brain regions involved in modulating circadian rhythms ...
Fogo, Garrett M., Gall, Andrew J., Shuboni-Mulligan, Dorela D.   +2 more
core   +1 more source

Impact of Human Melanopsin Gene (OPN4) Polymorphisms (I394T, P10L) on Nocturnal Melatonin and Daily Rhythms in Young Adults

Journal of Pineal Research, Volume 78, Issue 5, September 2026.
ABSTRACT The present study investigates the impact of two missense SNPs in the human melanopsin gene OPN4 ‐I394T (rs1079610) and P10L (rs2675703)‐ on non‐image‐forming (NIF) physiological and behavioural outputs in healthy young adults under real‐world conditions.
Jesús Vicente‐Martínez, María Ángeles Bonmatí‐Carrión, Ana María López‐Parra, Juan Antonio Madrid, Pedro Francisco Almaida‐Pagán, María Angeles Rol   +5 more
wiley   +1 more source

Mathematical Modeling of Melanopsin's Light Response in ipRGCs and Hek Cells [PDF]

Biophysical Journal, 2015
Melanopsin is an unusual vertebrate photopigment that, in mammals, is expressed in a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs), whose signaling has been implicated in non-image forming vision, regulating such functions as circadian rhythms, pupillary light response, and sleep.
Robinson, Phyllis R., Jackson, Abigail, Ortega, Jessica, Kang, Hyewon, Hoffman, Kathleen   +4 more
openaire   +1 more source

Pivotal roles of melanopsin containing retinal ganglion cells in pupillary light reflex in photopic conditions

Frontiers in Cellular Neuroscience
The pupillary light reflex (PLR) is crucial for protecting the retina from excess light. The intrinsically photosensitive retinal ganglion cells (ipRGCs) in the retina are neurons that are critical to generating the PLR, receiving rod/cone photoreceptor ...
Jeremy Matthew Bohl, Abdul Rhman Hassan, Zachary J. Sharpe, Megi Kola, Angela Shehu, Deborah Langrill Beaudoin, Tomomi Ichinose   +6 more
doaj   +1 more source