IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis [PDF]
Cell Death and Disease, 2023 The activation of the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome triggers pyroptosis proinflammatory cell death in experimental autoimmune encephalomyelitis (EAE).
Yuanyuan Wang +9 more
doaj +4 more sources
The IRAK-M death domain: a tale of three surfaces [PDF]
Frontiers in Molecular Biosciences, 2023 The anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M) is a negative regulator of MyD88/IRAK-4/IRAK-1 signaling. However, IRAK-M has also been reported to activate NF-κB through the MyD88/IRAK-4/IRAK-M myddosome in a MEKK-3 dependent ...
Berke Gürkan +26 more
doaj +4 more sources
SARS-CoV-2/ACE2 Interaction Suppresses IRAK-M Expression and Promotes Pro-Inflammatory Cytokine Production in Macrophages [PDF]
Frontiers in Immunology, 2021 The major cause of death in SARS-CoV-2 infected patients is due to de-regulation of the innate immune system and development of cytokine storm. SARS-CoV-2 infects multiple cell types in the lung, including macrophages, by engagement of its spike (S ...
Ioanna Pantazi +11 more
doaj +3 more sources
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation [PDF]
Nature Communications, 2018 Interleukin 33 (IL-33) is among the earliest-released cytokines in response to allergens that orchestrate type 2 immunity. The prolyl cis-trans isomerase PIN1 is known to induce cytokines for eosinophil survival and activation by stabilizing cytokines ...
Morris Nechama +15 more
doaj +4 more sources
Role of IRAK-M in alcohol induced liver injury. [PDF]
PLoS ONE, 2013 Increasing evidence suggests that innate immunity plays an important role in alcohol-induced liver injury and most studies have focused on positive regulation of innate immunity.
Yipeng Wang +8 more
doaj +4 more sources
IRAK-M expression limits dendritic cell activation and proinflammatory cytokine production in response to Helicobacter pylori. [PDF]
PLoS ONE, 2013 Helicobacter pylori (H. pylori) infects the gastric mucosa and persists for the life of the host. Bacterial persistence may be due to the induction of regulatory T cells (Tregs) whichmay have protective effects against other diseases such as asthma.
Jessica Shiu +4 more
doaj +4 more sources
IRAK-M Deficiency Exacerbates Ischemic Neurovascular Injuries in Experimental Stroke Mice [PDF]
Frontiers in Cellular Neuroscience, 2018 Background: Innate immune response to neuronal death is one of the key events of the pathogenesis of ischemic brain injury. Interleukin-1 receptor-associated kinase (IRAK)-M, encoded by gene Irak3, negatively regulates toll-like receptor signaling by ...
Chenfei Lyu +10 more
doaj +3 more sources
Gastric LTi cells promote lymphoid follicle formation but are limited by IRAK-M and do not alter microbial growth. [PDF]
Mucosal Immunol, 2015 Lymphoid tissue inducer (LTi) cells are activated by accessory cell IL-23, and promote lymphoid tissue genesis and antibacterial peptide production by the mucosal epithelium.
Shiu J +9 more
europepmc +7 more sources
A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via α7 nicotinic receptors in human macrophages. [PDF]
PLoS ONE, 2014 Nicotine stimulation of α7 nicotinic acetylcholine receptor (α7 nAChR) powerfully inhibits pro-inflammatory cytokine production in lipopolysaccharide (LPS)-stimulated macrophages and in experimental models of endotoxemia.
Maria C Maldifassi +8 more
doaj +4 more sources
IRAK-M regulates chromatin remodeling in lung macrophages during experimental sepsis. [PDF]
PLoS ONE, 2010 Sepsis results in a profound state of immunosuppression, which is temporally associated with impaired leukocyte function. The mechanism of leukocyte reprogramming in sepsis is incompletely understood. In this study, we explored mechanisms contributing to
Kenneth Lyn-Kew +7 more
doaj +4 more sources