Results 11 to 20 of about 9,313 (272)
IRAK-M has effects in regulation of lung epithelial inflammation [PDF]
Respiratory Research, 2023 Background Epithelial barrier is important for asthma development by shaping immune responses. Airway expressing-IL-1 receptor-associated kinase (IRAK)-M of Toll-like receptor pathway was involved in immunoregulation of airway inflammation through ...
Jia Li +5 more
doaj +6 more sources
Correction: Role of IRAK-M in Alcohol Induced Liver Injury
PLoS ONE, 2014 Dr. Huiping Yan is co-corresponding author with Dr. Li Wen. Dr.
Yipeng Wang +8 more
doaj +8 more sources
Effect of IRAK-M on Airway Inflammation Induced by Cigarette Smoking [PDF]
Mediators of Inflammation, 2017 Background. IRAK-M, negatively regulating Toll-like receptor, is shown the dual properties in the varied disease contexts. We studied the effect of IRAK-M deficiency on cigarette smoking- (CS-) induced airway inflammation under acute or subacute ...
Haihong Gong +4 more
doaj +5 more sources
IRAK-M regulation and function in host defense and immune homeostasis [PDF]
Infectious Disease Reports, 2010 Antigen presenting cells (APCs) of the innate immune system sense a wide range of pathogens via pattern recognition receptors (PRRs). Engagement of certain PRRs can induce production of pro-inflammatory mediators that facilitate effective clearance of ...
Leah L.N. Hubbard, Bethany B. Moore
doaj +5 more sources
IRAK-M Regulates Monocyte Trafficking to the Lungs in Response to Bleomycin Challenge. [PDF]
J Immunol, 2020 Abstract Idiopathic pulmonary fibrosis is a deadly disease characterized by excessive extracellular matrix deposition in the lungs, resulting in decreased pulmonary function. Although epithelial cells and fibroblasts have long been the focus of idiopathic pulmonary fibrosis research, the role of various subpopulations of macrophages in ...
Reader BF +8 more
europepmc +5 more sources
Neutrophils Deficient in Innate Suppressor IRAK-M Enhances Anti-tumor Immune Responses. [PDF]
Mol Ther, 2020 Tumor-associated immune-suppressive neutrophils are prevalent in various cancers, including colorectal cancer. However, mechanisms of immune-suppressive neutrophils are not well understood. We report that a key innate suppressor, IRAK-M (interleukin-1 receptor-associated kinase M), is critically involved in the establishment of immune-suppressive ...
Zhang Y +5 more
europepmc +5 more sources
Critical Role of IRAK-M in Regulating Antigen-Induced Airway Inflammation. [PDF]
Am J Respir Cell Mol Biol, 2017 Asthma is an airway epithelium disorder involving allergic lung inflammation. IL-1 receptor-associated kinase M (IRAK-M) is a negative regulator of Toll-like receptor (TLR) signaling on airway epithelial cells and macrophages, and it is known to limit the overproduction of cytokines during the inflammatory process. However, the direct role of IRAK-M in
Zhang M, Chen W, Zhou W, Bai Y, Gao J.
europepmc +6 more sources
Changes in plasma IRAK-M in patients with prediabetes and its relationship with related metabolic indexes: a cross-sectional study [PDF]
Journal of International Medical Research, 2022 Objective To investigate whether IL-1R-associated kinase (IRAK)-M is associated with prediabetes and type 2 diabetes (T2D). Methods In this cross-sectional study, enrolled subjects were assigned to different groups according to their fasting plasma ...
Xiaomin Xie +5 more
doaj +2 more sources
IRAK-M deficiency promotes the development of type 1 diabetes in NOD mice. [PDF]
Diabetes, 2014 Type 1 diabetes mellitus (T1DM) is an organ-specific autoimmune disease characterized by progressive destruction of insulin-secreting pancreatic β-cells. Both T-cell–mediated adaptive responses as well as innate immune processes are involved in pathogenesis.
Tan Q +6 more
europepmc +7 more sources
The structure function of the death domain of human IRAK-M. [PDF]
Cell Commun Signal, 2014 IRAK-M is an inhibitor of Toll-like receptor signaling that acts by re-directing IRAK-4 activity to TAK1 independent NF-κB activation and by inhibition of IRAK-1/IRAK-2 activity. IRAK-M is expressed in monocytes/macrophages and lung epithelial cells. Lack of IRAK-M in mice greatly improves the resistance to nosocomial pneumonia and lung tumors, which ...
Du J +5 more
europepmc +5 more sources