Results 31 to 40 of about 9,313 (272)

Involvement of IRAK-M in Peptidoglycan-induced Tolerance in Macrophages [PDF]

Journal of Biological Chemistry, 2004
The molecular mechanisms by which pathogen-associated molecular patterns recognized by TLR2, such as peptidoglycan (PGN), induce homotolerance are largely unknown. It was recently reported that IRAK-M negatively regulates TLR signaling. In this study, we elucidate the molecular mechanisms of tolerance induced by PGN, with a focus on the role of IRAK-M.
Kuniko Nakayama, Shu Okugawa, Shintaro Yanagimoto, Takatoshi Kitazawa, Kunihisa Tsukada, Miki Kawada, Satoshi Kimura, Koichi Hirai, Yohtaroh Takagaki, Yasuo Ota   +9 more
openalex   +4 more sources

Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration [PDF]

Science Translational Medicine
Chronic inflammation is a constitutive component of many age-related diseases, including age-related macular degeneration (AMD). Here, we identified interleukin-1 receptor-associated kinase M (IRAK-M) as a key immunoregulator in retinal pigment ...
Bell, Oliver H, Chan, Ying Kai, Clare, Alison J, Coffey, Peter J, Copland, David A, Cox, Katherine, Dick, Andrew D, Fletcher, Erica L, Gorski, Mathias, Greferath, Ursula, Guymer, Robyn, Hageman, Gregory S, Heid, Iris M, Li, Yingxin, Liu, Jian, Nicholson, Lindsay B, Ou, Kepeng, Powell, Jenna Le Brun, Radeke, Monte J, Richards, Burt T, Robles, Luis Martinez, Scott, Louis, Shi, Gongyu, Theodoropoulou, Sofia, Wu, Jiahui   +24 more
core   +5 more sources

IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling [PDF]

Cell, 2002
Toll-like receptors (TLRs) detect microorganisms and protect multicellular organisms from infection. TLRs transduce their signals through MyD88 and the serine/threonine kinase IRAK. The IRAK family consists of two active kinases, IRAK and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M.
Koichi S. Kobayashi, Lorraine D. Hernandez, Jorge E. Galán, Charles A. Janeway, Ruslan Medzhitov, Richard A. Flavell   +5 more
openalex   +3 more sources

Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M. [PDF]

Nat Commun, 2015
AbstractGlucocorticoids are among the most commonly used anti-inflammatory agents. Despite the enormous efforts in elucidating the glucocorticoid-mediated anti-inflammatory actions, how glucocorticoids tightly control overactive inflammatory response is not fully understood.
Miyata M, Lee JY, Susuki-Miyata S, Wang WY, Xu H, Kai H, Kobayashi KS, Flavell RA, Li JD.   +8 more
europepmc   +4 more sources

IRAK-M Regulates Proliferative and Invasive Phenotypes of Lung Fibroblasts

Inflammation, 2022
Lung fibroblasts play an important role in subepithelial fibrosis, one feature for airway remodeling. IL-1 receptor-associated kinase (IRAK)-M was shown to involve fibrosis formation in airways and lung through regulation of inflammatory responses. IRAK-M is expressed by lung fibroblasts, whether IRAK-M has direct impact on lung fibroblasts remains ...
Zheng, Z, Li, J, Cui, Y, Wang, W, Zhang, M, Zhang, Y, Bai, Y, Ying, S, Gao, G   +8 more
openaire   +4 more sources

IRAK‐M in macrophages around septically and aseptically loosened hip implants [PDF]

Journal of Biomedical Materials Research Part A, 2011
AbstractThe most common long‐term complication of joint arthroplasty is loosening, which is mediated by chronic inflammatory cytokines produced by macrophages stimulated by implant‐derived debris and eventually bacterial components adherent to such debris.
Yangchun Zhang, Changhe Hou, Shiming Yu, Jianhong Xiao, Ziji Zhang, Qiyi Zhai, Jianwei Chen, Ziqing Li, Xibao Zhang, Matti Lehto, Yrjö T. Konttinen, Puyi Sheng   +11 more
openalex   +3 more sources

A novel mouse model of conditional IRAK-M deficiency in myeloid cells: application in lung Pseudomonas aeruginosa infection. [PDF]

Innate Immun, 2017
Jiang D, Matsuda J, Berman R, Schaefer N, Stevenson C, Gross J, Zhang B, Sanchez A, Li L, Chu HW.   +9 more
europepmc   +3 more sources

Endotoxin Tolerant Dendritic Cells Suppress Inflammatory Responses in Splenocytes via Interleukin-1 Receptor Associated Kinase (IRAK)-M and Programmed Death-Ligand 1 (PDL-1). [PDF]

Med Sci Monit, 2018
Zhou Y, Xia Q, Wang X, Fu S.
europepmc   +3 more sources

Interleukin-1 receptor-associated kinase 2- and protein kinase D1-dependent regulation of IRAK-monocyte expression by CpG DNA. [PDF]

PLoS ONE, 2012
As a part of the negative feedback mechanism, CpG DNA induces IRAK-M expression in monocytic cells. In the present study we investigated a biochemical signaling pathway and the transcription factors responsible for CpG DNA-mediated Irak-m gene expression.
Young-In Kim, Jeoung-Eun Park, Ki Han Kwon, Cheol Yi Hong, Ae-Kyung Yi   +4 more
doaj   +1 more source

IRAK-4 in macrophages contributes to inflammatory osteolysis of wear particles around loosened hip implants

Innate Immunity, 2021
TLRs recognizing PAMPS play a role in local immunity and participate in implant-associated loosening. TLR-mediated signaling is primarily regulated by IL-1 receptor associated kinase-M (IRAK-M) negatively and IRAK-4 positively.
Yang-chun Zhang, Jian-hong Xiao, Shao-jie Deng, Guo-liang Yi   +3 more
doaj   +1 more source