Results 161 to 170 of about 15,652 (205)

IRE1 gives weight to obesity-associated inflammation

Nature Immunology, 2017
IRE1α is a stress sensor that is activated by a high-fat diet. In adipose-tissue macrophages, it serves as a major switch toward pro-inflammatory M1 polarization and thereby contributes to obesity and associated diseases.
Bojan Bujisic, Fabio Martinon
openaire   +3 more sources

Principles of IRE1 Modulation Using Chemical Tools

2011
Perturbations that derail the proper folding and assembly of proteins in the endoplasmic reticulum (ER) lead to misfolded protein accrual in the ER-a toxic condition known as ER stress. The unfolded protein response (UPR) is a signaling system evolved to detect and rectify ER stress.
Kenneth P K, Lee, Frank, Sicheri
openaire   +2 more sources

IRE1 and efferent signaling from the endoplasmic reticulum

Journal of Cell Science, 2000
ABSTRACT Genetic analysis of the cellular adaptation to malfolded proteins in the endoplasmic reticulum (the unfolded protein response – UPR) has revealed a novel signaling pathway initiated by activation of IRE1, an ER-resident protein kinase and endonuclease.
F, Urano, A, Bertolotti, D, Ron
openaire   +2 more sources

Role of IRE1 in glioma development – a preclinical study

2009
Objective: Ischemia is associated with glioma development and locally induces an adaptive response which confers an enhanced survival and a more agressive behaviour to tumor cells. Hypoxia or glucose deprivation activate complex intracellular signaling referred to as the Unfolded Protein Response (UPR).[for full text, please go to the a.m. URL]
Auf, G, Guérit, S, Jabouille, A, Gaiser, T, Bikfalvi, A, Moenner, M   +5 more
openaire   +1 more source

Adaptation of the Secretory Pathway in Cancer Through IRE1 Signaling

2015
The unfolded protein response (UPR) was originally identified as a signaling network coordinating adaptive and apoptotic responses to accumulation of unfolded proteins in the endoplasmic reticulum (ER). More recent work has shown that UPR signaling can be triggered by a multitude of cellular events and that the UPR plays a critical role in the ...
Lhomond, Stéphanie, Pallares, Nestor, Barroso, Kim, Schmit, Kathleen, Dejeans, Nicolas, Fazli, Hélèna, Taouji, Saïd, Patterson, John B., Chevet, Eric   +8 more
openaire   +3 more sources

Ire1

AfCS-Nature Molecule Pages, 2007
Martin Schröder, Randal Kaufman
openaire   +1 more source

MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α

Cell Reports, 2023
Mart Saarma, Vera Kovaleva, Ave Eesmaa   +2 more
exaly  

The functions of IRE1α in neurodegenerative diseases: Beyond ER stress

Ageing Research Reviews, 2022
Qian Jiao, Mingxia Bi, Xixun Du
exaly  

Pharmacological targeting of Ire1 of Candida albicans

Research Journal of Biotechnology
The common fungal pathogen Candida albicans primarily affects immunocompromised individuals and the rise in antifungal resistance underscores the urgent need for new treatment options. In this study, we investigate the potential of STF-83010, a human Ire1 inhibitor, as a treatment for candidiasis. Our findings reveal that STF-83010 effectively inhibits
openaire   +1 more source

IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis

Journal of Cellular Physiology, 2022
Murad Alahdal, Wencui Li
exaly