Results 151 to 160 of about 15,652 (205)

QM/MM Free Energy Calculations of IRE1 Reveal a Unique Protonation State of the Catalytic Lys599. [PDF]

J Comput Chem
Carlesso A, Conflitti P, Mahdizadeh SJ, Deganutti G, Eriksson LA, Limongelli V.   +5 more
europepmc   +1 more source

Hypovirus-Induced Phosphorylation of CpIre1 Modulates Unfolded Protein Response and Virulence in Cryphonectria parasitica. [PDF]

Mol Plant Pathol
Zhao L, Wang F, Chen F, Su S, Qiu J, Chen B, Li R.   +6 more
europepmc   +1 more source

Enhancing Yeast Surface Display: UPR, ERAD, and ER Dynamics in Recombinant Protein Production. [PDF]

Food Technol Biotechnol
Martinić Cezar T, Paić A, Žunar B, Stuparević I, Mrša V, Teparić R.   +5 more
europepmc   +1 more source

Sucralose inhibited cell survival through the activation of ER stress in human endothelial progenitor cells. [PDF]

PLoS One
Li CY, Lin HY, Chiang EI, Hung HC, Tang FY.   +4 more
europepmc   +1 more source

A novel role for the E2F transcription factor and the ER stress sensor IRE1 in cytoplasmic DNA accumulation. [PDF]

Genetics
Das A, Li Y, Fan Y, Moon NS.
europepmc   +1 more source

FGF1 orchestrates circadian hepatic triglyceride secretion. [PDF]

Nat Commun
Sermikli BP, Liu S, Kim K, Hases L, van Zutphen T, Untereiner A, Torres J, He M, Crossley L, Dai Y, Zhu J, Koopari CL, Fan W, Truitt ML, Jonker JW, Atkins AR, Downes M, Evans RM.   +17 more
europepmc   +1 more source

Pyrazolylpyrimidinamines Decorated via Petasis Reaction as Small-Molecule Activators of the RNA-Degrading Ribonuclease IRE1α. [PDF]

ACS Bio Med Chem Au
Avathan Veettil AK, Liu Y, Wagner L, Hastürk O, Huynh NST, Mancino G, Beerbaum M, Wu P.   +7 more
europepmc   +1 more source

Endoplasmic reticulum stress in non-small cell lung cancer: a review of therapeutic agents, mechanistic insights, and implications for therapy. [PDF]

Front Cell Dev Biol
Luo Q, Gao X, Meng P, Qi X, Wang W, Li S, Duan L.   +6 more
europepmc   +1 more source

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Assays to Study IRE1 Activation and Signaling

2022
The endoplasmic reticulum (ER) stress sensor IRE1 is a a major player of the unfolded protein response (UPR), the main pathway driving adaptation processes to restore proteostasis.  In addition, overactivation of IRE1 signaling contributes to a variety of pathologies including diabetes, neurodegenerative diseases, and cancer. Under ER stress, IRE1 auto-
Paloma, Moraga, Raul, Aravena, Hery, Urra, Claudio, Hetz   +3 more
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Structural and molecular bases to IRE1 activity modulation

Biochemical Journal, 2021
The Unfolded Protein response is an adaptive pathway triggered upon alteration of endoplasmic reticulum (ER) homeostasis. It is transduced by three major ER stress sensors, among which the Inositol Requiring Enzyme 1 (IRE1) is the most evolutionarily conserved.
Timothy Langlais, Diana Pelizzari-Raymundo, Sayyed Jalil Mahdizadeh, Nicolas Gouault, Francois Carreaux, Eric Chevet, Leif A. Eriksson, Xavier Guillory   +7 more
openaire   +2 more sources