Results 171 to 180 of about 15,549 (206)

Assays to Study IRE1 Activation and Signaling

2022
The endoplasmic reticulum (ER) stress sensor IRE1 is a a major player of the unfolded protein response (UPR), the main pathway driving adaptation processes to restore proteostasis.  In addition, overactivation of IRE1 signaling contributes to a variety of pathologies including diabetes, neurodegenerative diseases, and cancer. Under ER stress, IRE1 auto-
Paloma, Moraga, Raul, Aravena, Hery, Urra, Claudio, Hetz   +3 more
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Structural and molecular bases to IRE1 activity modulation

Biochemical Journal, 2021
The Unfolded Protein response is an adaptive pathway triggered upon alteration of endoplasmic reticulum (ER) homeostasis. It is transduced by three major ER stress sensors, among which the Inositol Requiring Enzyme 1 (IRE1) is the most evolutionarily conserved.
Timothy Langlais, Diana Pelizzari-Raymundo, Sayyed Jalil Mahdizadeh, Nicolas Gouault, Francois Carreaux, Eric Chevet, Leif A. Eriksson, Xavier Guillory   +7 more
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IRE1 gives weight to obesity-associated inflammation

Nature Immunology, 2017
IRE1α is a stress sensor that is activated by a high-fat diet. In adipose-tissue macrophages, it serves as a major switch toward pro-inflammatory M1 polarization and thereby contributes to obesity and associated diseases.
Bojan Bujisic, Fabio Martinon
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IRE1 and efferent signaling from the endoplasmic reticulum

Journal of Cell Science, 2000
ABSTRACT Genetic analysis of the cellular adaptation to malfolded proteins in the endoplasmic reticulum (the unfolded protein response – UPR) has revealed a novel signaling pathway initiated by activation of IRE1, an ER-resident protein kinase and endonuclease.
F, Urano, A, Bertolotti, D, Ron
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Principles of IRE1 Modulation Using Chemical Tools

2011
Perturbations that derail the proper folding and assembly of proteins in the endoplasmic reticulum (ER) lead to misfolded protein accrual in the ER-a toxic condition known as ER stress. The unfolded protein response (UPR) is a signaling system evolved to detect and rectify ER stress.
Kenneth P K, Lee, Frank, Sicheri
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Role of IRE1 in glioma development – a preclinical study

2009
Objective: Ischemia is associated with glioma development and locally induces an adaptive response which confers an enhanced survival and a more agressive behaviour to tumor cells. Hypoxia or glucose deprivation activate complex intracellular signaling referred to as the Unfolded Protein Response (UPR).[for full text, please go to the a.m. URL]
Auf, G, Guérit, S, Jabouille, A, Gaiser, T, Bikfalvi, A, Moenner, M   +5 more
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Adaptation of the Secretory Pathway in Cancer Through IRE1 Signaling

2015
The unfolded protein response (UPR) was originally identified as a signaling network coordinating adaptive and apoptotic responses to accumulation of unfolded proteins in the endoplasmic reticulum (ER). More recent work has shown that UPR signaling can be triggered by a multitude of cellular events and that the UPR plays a critical role in the ...
Lhomond, Stéphanie, Pallares, Nestor, Barroso, Kim, Schmit, Kathleen, Dejeans, Nicolas, Fazli, Hélèna, Taouji, Saïd, Patterson, John B., Chevet, Eric   +8 more
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Abstract 2084: Reactive oxygen species activate the IRE1-XBP1 pro-apoptotic pathway by recruiting TRAF2 to IRE1 and activating an IRE1-TRAF2-JNK pathway in human glioma cells

Cancer Research, 2011
Abstract To investigate the function of the oxidative stress in the endoplasmic reticulum (ER) -related cell death of glioma, the human glioma cells were treated with hydrogen peroxide, TNF, and thapsigargin to raise intracellular levels of hydroxyl radical and ER stress, respectively.
Yeon Hyang Kim, Hyung-Kon Koh
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Structural Insights into IRE1 Functions in the Unfolded Protein Response

Current Medicinal Chemistry, 2016
IRE1 signaling is the most evolutionarily conserved branch in the UPR. IRE1 is an ER stress sensor and provides a structure-based platform for the unfolded proteins docking, which causes the luminal domain conformational change and oligomerization.
Jianqiong, Yang, Haiqing, Liu, Linfu, Li, Hai, Liu, Weimei, Shi, Xiaoliang, Yuan, Longhuo, Wu   +6 more
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Getting RIDD of RNA: IRE1 in cell fate regulation

Trends in Biochemical Sciences, 2014
Inositol-requiring enzyme 1 (IRE1) is the most conserved transducer of the unfolded protein response (UPR), a homeostatic response that preserves proteostasis. Intriguingly, via its endoribonuclease activity, IRE1 produces either adaptive or death signals.
M, Maurel, E, Chevet, J, Tavernier, S, Gerlo   +3 more
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