Results 181 to 190 of about 15,549 (206)

Ire1

AfCS-Nature Molecule Pages, 2007
Martin Schröder, Randal Kaufman
openaire   +1 more source

Pharmacological targeting of Ire1 of Candida albicans

Research Journal of Biotechnology
The common fungal pathogen Candida albicans primarily affects immunocompromised individuals and the rise in antifungal resistance underscores the urgent need for new treatment options. In this study, we investigate the potential of STF-83010, a human Ire1 inhibitor, as a treatment for candidiasis. Our findings reveal that STF-83010 effectively inhibits
openaire   +1 more source

OST component RPN1 is a novel regulator of IRE1 RNase activity that interacts with multiple distinct IRE1 and PERK complexes

Abstract The unfolded protein response (UPR) is an essential cell signalling system that regulates ER protein homeostasis. IRE1 and PERK are receptor proteins that propagate the UPR signal from the ER to the cytosol. Both receptors are suggested to interact with various proteins from different biological pathways, although the scale and
Natacha Larburu, Freya Storer, Yassin Ben-Khoud, Chao-Sheng Chen, Christopher J Adams, Tony D Southall, Maruf MU Ali   +6 more
openaire   +1 more source

MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α

Cell Reports, 2023
Vera Kovaleva, Ave Eesmaa, Mart Saarma   +2 more
exaly  

The functions of IRE1α in neurodegenerative diseases: Beyond ER stress

Ageing Research Reviews, 2022
Mingxia Bi, Xixun Du, Qian Jiao
exaly  

The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate

Biomedicines, 2021
Natalia Siwecka, Wioletta Rozpedek-Kaminska, Adam Wawrzynkiewicz   +2 more
exaly  

Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes

Cell Metabolism, 2020
Yi-Guang Chen, Sündüz Keles, Rupa Sridharan   +2 more
exaly  

IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis

Journal of Cellular Physiology, 2022
Wencui Li, Wang Daping, Murad Alahdal
exaly  

Targeting IRE1 activity in Glioblastoma Multiforme

Ciblage d'IRE1 dans le glioblastome multiforme Le réticulum endoplasmique (RE) est un organite membranaire intracellulaire et le premier compartiment de la voie de sécrétion. En tant que tel, le RE contribue à la production et au repliement d’environ un tiers des protéines cellulaires et est donc lié au maintien de l’homéostasie ...
openaire   +1 more source

Review: The two faces of IRE1 and their role in protecting plants from stress

Plant Science, 2021
Zhaoxia Li, Stephen H Howell
exaly