Results 151 to 160 of about 81,945 (302)

The Role of IGF2BP3‐Mediated Immune Response Activation in Enhancing Immunotherapy of Koumine for Gastric Cancer

Cancer Science, EarlyView.
Koumine binds IGF2BP3 and promotes its proteasomal degradation, reducing m6A on EED mRNA, accelerating EED decay, lowering H3K27me3, and promoting IRF transcription, thereby restoring MHC‐I and enhancing CD8+ T cell killing. ABSTRACT Resistance to immune checkpoint blockade in gastric cancer often arises from defective antigen presentation due to MHC‐I
Qiu Hongqiang, Lin Hailing, Lou Luqi, Wang Linyao, Lin Tian, Shengjie Zhu, Zhang Dongmei, Chen Rong, Mao Yunyi, Wancai Que, Yu Cheng   +10 more
wiley   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

条纹斑竹鲨IRF-1基因的克隆和特征分析

, 2011
鱼类中IRF-1基因的克隆测序目前仅局限于辐鳍鱼类[1,2],而在软骨鱼类中未见报道。IRF-1是干扰素调节因子家族的成员之一[3]。除作为干扰素的转录调节因子外[4],还具有其他功能[5—10]。作为天然免疫重要的调节因子其基因在哺乳类中得到了广泛的克隆和分析。IRF-1与其他家族成员一样,在氨基末端前115个氨基酸都具较高同源性 ...
甘小妮, 陈新文
core  

Information and communication technology innovations and labor hours: A business cycle analysis

Economic Inquiry, EarlyView.
Abstract This paper examines the impact of changes in information and communication technologies (ICTs) on skilled and unskilled labor at the business cycle frequency. To achieve this, we construct aggregate hours series for both labor groups using the monthly outgoing rotation group of the Current Population Survey from 1994 to 2023.
Sangheon Ahn, Soojin Jo, Myungkyu Shim
wiley   +1 more source

From productive coupling to catalytic commitment: An evolutionarily tuned interdomain connector in Leishmania Aha1 orchestrates Hsp90 activation

The FEBS Journal, EarlyView.
LbAha1 activates LbHsp90 through a multistep mechanism in which productive N‐domain docking precedes ATP‐driven rearrangement and linker ordering. The LbAha1 linker transitions from a flexible to helical state, stabilizing an asymmetric, catalytically competent closed complex.
Paulo Roberto Dores‐Silva, Thiago Vargas Seraphim, Karine Minari, Izabella Rodrigues Fonseca da Silva, Winston Pinheiro Claro Gomes, Leijiane Figueira de Sousa, Arthur Moraes Franco da Rocha, Leandro Ramos Souza Barbosa, Jeremiah Stanson Joseph, Júlio César Borges   +9 more
wiley   +1 more source

Studying Csar Systems Using Irf-Csar

, 2012
In this paper, Impulse Response Function in Circular Synthetic Aperture Radar Imaging (IRF-CSAR), which is a special version of Impulse Response Function in Ultrawideband-Ultrawidebeam Synthetic Aperture Radar Imaging (IRF-USAR), is presented and shown ...
Minardi, Michael, Vu, Viet Thuy,, Pettersson, Mats,, Sjogren, Thomas,   +3 more
core  

Different rehabilitation destinations: non-clinical factors associated with inpatient rehabilitation versus skilled nursing placement. [PDF]

Front Rehabil Sci
Hayes HA, Zhang C, Xiang S, Smith B, Williams P, Presson AP, French M.   +6 more
europepmc   +1 more source

Geopolitical Risk and Domestic Bank Deposits

Financial Management, EarlyView.
ABSTRACT We investigate the relationship between global geopolitical risk and bank deposit flows across a wide panel of European countries. Motivated by the pivotal role of deposit stability for financial intermediation and systemic resilience, we explore whether geopolitical shocks alter depositors’ portfolio choices.
Dimitris Anastasiou, Theodore Kapopoulos, Steven Ongena, Athanasios Sakkas   +3 more
wiley   +1 more source

Early Intraretinal Fluid Reduction is Linked to Vision Gains in Patients with Diabetic Macular Edema. [PDF]

Ophthalmol Ther
Wang Y, Hibar DP, Sadda S, Lim JI, Chan CK, Tan GS, Talcott KE, Gibson K, Maunz A, Lu H, Albrecht T, Amador M, Litts KM.   +12 more
europepmc   +1 more source

A global perspective on the annual cycles of whimbrels

Ibis, EarlyView.
Comparative analyses are central to understanding broad‐scale patterns in avian ecology, yet their application is often constrained by fragmented and uneven data availability. Recent advances in tracking technology have generated unprecedented insights into shorebird movements, resulting in numerous studies on single populations or flyways.
Camilo Carneiro, Tómas G. Gunnarsson, Gary Allport, Philip W. Atkinson, Anne N. M. A. Ausems, Pierrick Bocher, Roeland Bom, Malo Braquier, Stephen C. Brown, Sayam U. Chowdhury, Paula Cimprich, Delip K. Das, Charlotte Francesiaz, Robert E. Gill, Diana J. Hamilton, Maina C. Handmaker, Shariful Islam, Audrey Jaeger, Frédéric Jiguet, Chrystyn Jones, Emmanuel Joyeux, Jeffrey F. Kelly, Alan H. Kneidel, Fenliang Kuang, Chris Latty, Mathieu Le Corre, David Li, Rebeca C. Linhart, Ádám Lovas‐Kiss, Zhijun Ma, Scott McWilliams, Verónica Méndez, Jason Mobley, Samuel NG, Joshua Nightingale, Erica Nol, Julie Paquet, Theunis Piersma, Marie Pitts, Rivo Rabarisoa, Florinah Razafimandimby, Daniel R. Ruthrauff, Felicia Sanders, Shiloh Schulte, Philipp Schwemmer, Nathan R. Senner, Böðvar Þórisson, Lee Tibbitts, Nils Warnock, Bryan Watts, Brad Winn, Samantha J. Wolfe, Shufen Yang, José A. Alves   +53 more
wiley   +1 more source