Results 191 to 200 of about 81,945 (302)

Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation

The Journal of Physiology, EarlyView.
Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min, Órlaith C. Henry, Luke A. J. O'Neill   +2 more
wiley   +1 more source

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study. [PDF]

Invest Ophthalmol Vis Sci
Midena E, Lupidi M, Frizziero L, Midena G, Pilotto E, Toto L, Cicinelli MV, Veritti D, Covello G, Lattanzio R, Figus M, Danieli L, Borrelli E, Reibaldi M, Tognetto D, Inferrera L, Donati S, Rossi S, Melillo P, Lanzetta P, Sarao V, Gregori G, Cagini C, Eandi CM, Carnevali A, Scorcia V, Maggio E, Pertile G, Costagliola C, Cennamo G, Mora P, Dell'Omo R, Affatato M, Passamonti M, Parravano M, Lassandro NV, Nassisi M, Viola F, Castellino N, Cappellani F, Giannaccare G, Boscia F, Grassi MO, Musetti D, Folegani V, Invernizzi A, Rossetti L, Bacci T, Ricci F, Lombardo M, Romano M, Valsecchi N, Coppola M, Cavarzeran F.   +53 more
europepmc   +1 more source

Astrocytic EAAT‐2 Upregulation Supports Neuro‐Axonal Homeostasis in Chronic Inflammatory CNS Lesions

Glia, Volume 74, Issue 12, December 2026.
Inflammatory CNS lesions increase extracellular glutamate. Astrocytic EAAT regulation controls glutamate clearance, stabilizes axonal Ca2+ homeostasis, and determines neurite survival during chronic neuroinflammation. ABSTRACT Neuronal loss in multiple sclerosis (MS) is a key factor in the progression of disability.
Luise Reukauf, Anca Margineanu, Bakhrom Muinjonov, Jessy Chen, Yiqin Cui, Kamil Rosiewicz, Helena Radbruch, Ian Munro, Marlen Alisch, Volker Siffrin   +9 more
wiley   +1 more source

Artificial intelligence-based fluid quantification predicts clinical outcomes in diabetic macular oedema eyes treated with intravitreal dexamethasone implants: DIADEMA project. [PDF]

Br J Ophthalmol
Franquesa-Garcia F, Romero-Nuñez B, Martin-Pinardel R, De Zanet S, González-López JJ, Escobar-Barranco JJ, Ruiz-Del-Tiempo MP, Boixadera A, Fonollosa A, Gómez-Benlloch A, Velazquez-Villoria D, Fernández-Vigo JI, Garay-Aramburu G, Parrado-Carrillo A, Castillon L, Gómez Sánchez S, Lavid FJ, Arruabarrena C, Figueras-Roca M, Bernal-Morales C, Ciller C, Zarranz-Ventura J, DIADEMA investigators.   +22 more
europepmc   +1 more source

Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang, Songhang Xing, Shanshan Zhang, Yuan Hao, Xiaojie Qu, Wurihan Bao, Manwei Hao, Han Sun, Mingyuan Dong, Huiling Zhang, Dan Huang, Yiqi Wang, Xuanjie Jiang, Xiaoyu Pu, Yanyan Chi, Xingtong Wang, Xuefeng Li   +16 more
wiley   +1 more source

IRF-1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. [PDF]

Animal Model Exp Med
Zhang J, Zhang J, Song S, Li M, Sun L, Zhu Z, Lin D.   +6 more
europepmc   +1 more source

MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

Immunology, Volume 179, Issue 4, Page 537-553, December 2026.
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Attaway, Nicole Welch, Srinivasan Dasarathy   +6 more
wiley   +1 more source

From Trials to Treatment: Current Evidence Supporting Faricimab Use in nAMD and DME. [PDF]

J Clin Med
Ruiz-Moreno JM, Bernal-Morales C, Esteban-Floría O, Rodríguez-de-la-Rúa E, Remolí-Sargues L, Borras-Blasco J, Gómez-Benlloch A, Cilveti E, Valsero-Franco S, Arriola-Naharro C, García-Lunar P, Kaminski-Santamaría S, Muñoz-Molina B, García-Layana A.   +13 more
europepmc   +1 more source

Challenging White Lesion

Oral Diseases, EarlyView.
Michele Di Benedetto, Izabel Regina Fischer Rubira‐Bullen, Cássia Maria Fischer Rubira, Paulo Sérgio da Silva Santos, Vanessa Soares Lara, Camila Lopes Cardoso   +5 more
wiley   +1 more source

Nurses' Scope of Practice in Home‐Based Care: An Observational Study of Care Activities, Clinical Decision‐Making, and Contextual Modulators—The DECIDE Project

Journal of Clinical Nursing, Volume 35, Issue 12, Page 5386-5399, December 2026.
ABSTRACT Background and Aim Nurses' scope of practice is central to healthcare delivery. While scope of practice is well described conceptually, there is limited empirical research capturing how it is enacted in everyday clinical practice. This study aimed to describe scope of practice in home‐based care, focusing on care activities, clinical decision ...
Ida Røed Flyum, Gunilla Borglin, Anna Josse Eklund, Veronica Pavedahl, Edith Roth Gjevjon   +4 more
wiley   +1 more source