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Erythropoiesis and Iron Sulfur Cluster Biogenesis [PDF]
Advances in Hematology, 2010 Erythropoiesis in animals is a synchronized process of erythroid cell differentiation that depends on successful acquisition of iron. Heme synthesis depends on iron through its dependence on iron sulfur (Fe-S) cluster biogenesis.
Hong Ye, Tracey A. Rouault
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Structural and biochemical investigations of a HEAT-repeat protein involved in the cytosolic iron-sulfur cluster assembly pathway [PDF]
Communications Biology, 2023 Iron-sulfur clusters are essential for life and defects in their biosynthesis lead to human diseases. The mechanism of cluster assembly and delivery to cytosolic and nuclear client proteins via the cytosolic iron-sulfur cluster assembly (CIA) pathway is ...
Sheena Vasquez +7 more
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The iron-sulfur cluster is essential for DNA binding by human DNA polymerase ε [PDF]
Scientific Reports, 2022 DNA polymerase ε (Polε) is a key enzyme for DNA replication in eukaryotes. Recently it was shown that the catalytic domain of yeast Polε (PolεCD) contains a [4Fe-4S] cluster located at the base of the processivity domain (P-domain) and coordinated by ...
Alisa E. Lisova +5 more
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Modulation of MagR magnetic properties via iron–sulfur cluster binding
Scientific Reports, 2021 Iron–sulfur clusters are essential cofactors found in all kingdoms of life and play essential roles in fundamental processes, including but not limited to respiration, photosynthesis, and nitrogen fixation.
Zhen Guo +11 more
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Iron–sulfur cluster biosynthesis [PDF]
Biochemical Society Transactions, 2008 Iron–sulfur (Fe–S) clusters are present in more than 200 different types of enzymes or proteins and constitute one of the most ancient, ubiquitous and structurally diverse classes of biological prosthetic groups. Hence the process of Fe–S cluster biosynthesis is essential to almost all forms of life and is remarkably conserved in prokaryotic and ...
Sibali, Bandyopadhyay +2 more
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Microbiology Spectrum, 2023 Iron-sulfur [Fe-S] clusters are one of the most ancient and functionally versatile natural biosynthetic prosthetic groups required by various proteins involved in important metabolic processes, including the oxidative phosphorylation of proteins ...
Xingju Song +5 more
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iScience, 2021 Summary: Mitochondria are a hallmark of eukaryal cells and play an important role in cellular metabolism. There is a vast amount of knowledge available on mitochondrial metabolism and essential mitochondrial functions, such as protein import and iron ...
Carl Malina +3 more
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Communications Chemistry, 2023 Iron-sulfur clusters are prosthetic groups of proteins involved in various biological processes. However, details of the immature state of the iron-sulfur cluster into proteins have not yet been elucidated. We report here the first structural analysis of
Erika Tsutsumi +9 more
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Crystallographic characterization of the high-potential iron-sulfur protein in the oxidized state at 0.8 Å resolution. [PDF]
PLoS ONE, 2017 High-potential iron-sulfur protein (HiPIP) is a soluble electron carrier protein of photosynthetic bacteria with an Fe4S4 cluster. Although structural changes accompanying the electron transfer are important for understanding of the functional mechanism,
Hiraku Ohno +6 more
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Redox-Sensing Iron–Sulfur Cluster Regulators [PDF]
Antioxidants & Redox Signaling, 2017 Iron-sulfur cluster proteins carry out multiple functions, including as regulators of gene transcription/translation in response to environmental stimuli. In all known cases, the cluster acts as the sensory module, where the inherent reactivity/fragility of iron-sulfur clusters with small/redox-active molecules is exploited to effect conformational ...
Crack, Jason C., Le Brun, Nick E.
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