Results 21 to 30 of about 31,278 (263)

Structural Basis of RICs Iron Donation for Iron-Sulfur Cluster Biogenesis

Frontiers in Microbiology, 2021
Escherichia coli YtfE is a di-iron protein of the widespread Repair of Iron Centers proteins (RIC) family that has the capacity to donate iron, which is a crucial component of the biogenesis of the ubiquitous family of iron-sulfur proteins.
Liliana S. O. Silva, Pedro M. Matias, Pedro M. Matias, Célia V. Romão, Lígia M. Saraiva   +4 more
doaj   +1 more source

The Iron Maiden. Cytosolic Aconitase/IRP1 Conformational Transition in the Regulation of Ferritin Translation and Iron Hemostasis

Biomolecules, 2021
Maintaining iron homeostasis is fundamental for almost all living beings, and its deregulation correlates with severe and debilitating pathologies.
Cécilia Hognon, Emmanuelle Bignon, Guillaume Harle, Nadège Touche, Stéphanie Grandemange, Antonio Monari   +5 more
doaj   +1 more source

Lights on Iron-Sulfur Clusters

Chemistry & Biology, 2009
The biogenesis of iron-sulfur proteins within a living cell is traditionally investigated by enzyme activity measurements and radiolabeling techniques. In this issue of Chemistry and Biology, Hoff et al. introduce a non-invasive fluorescence-based method to trace the formation of iron-sulfur clusters at high sensitivity.
Lillig, C., Lill, R.
openaire   +3 more sources

Iron-induced changes in the proteome of Trichomonas vaginalis hydrogenosomes. [PDF]

PLoS ONE, 2013
Iron plays a crucial role in metabolism as a key component of catalytic and redox cofactors, such as heme or iron-sulfur clusters in enzymes and electron-transporting or regulatory proteins.
Neritza Campo Beltrán, Lenka Horváthová, Petr L Jedelský, Miroslava Sedinová, Petr Rada, Michaela Marcinčiková, Ivan Hrdý, Jan Tachezy   +7 more
doaj   +1 more source

The Molecular Bases of the Dual Regulation of Bacterial Iron Sulfur Cluster Biogenesis by CyaY and IscX

Frontiers in Molecular Biosciences, 2018
IscX (or YfhJ) is a protein of unknown function which takes part in the iron-sulfur cluster assembly machinery, a highly specialized and essential metabolic pathway. IscX binds to iron with low affinity and interacts with IscS, the desulfurase central to
Salvatore Adinolfi, Rita Puglisi, Jason C. Crack, Clara Iannuzzi, Clara Iannuzzi, Fabrizio Dal Piaz, Petr V. Konarev, Petr V. Konarev, Dmitri I. Svergun, Stephen Martin, Nick E. Le Brun, Annalisa Pastore, Annalisa Pastore   +12 more
doaj   +1 more source

Escherichia coli RIC is able to donate iron to iron-sulfur clusters. [PDF]

PLoS ONE, 2014
Escherichia coli RIC (Repair of Iron Centers) is a diiron protein previously reported to be involved in the repair of iron-sulfur proteins damaged by oxidative or nitrosative stresses, and proposed to act as an iron donor.
Lígia S Nobre, Ricardo Garcia-Serres, Smilja Todorovic, Peter Hildebrandt, Miguel Teixeira, Jean-Marc Latour, Lígia M Saraiva   +6 more
doaj   +1 more source

Hybrid Methods in Iron-Sulfur Cluster Biogenesis [PDF]

Frontiers in Molecular Biosciences, 2017
Hybrid methods, which combine and integrate several biochemical and biophysical techniques, have rapidly caught up in the last twenty years to provide a way to obtain a fuller description of proteins and molecular complexes with sizes and complexity otherwise not easily affordable.
Prischi, Filippo, Pastore, Annalisa
openaire   +4 more sources

Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifB

Nature Communications, 2018
NifB is a key enzyme in the biosynthesis pathway of the nitrogenase FeMo cofactor. Here, the authors investigate the maturation of its iron-sulfur clusters by EPR and biochemical analyses, showing how individual precursor clusters participate in the ...
Lee A. Rettberg, Jarett Wilcoxen, Chi Chung Lee, Martin T. Stiebritz, Kazuki Tanifuji, R. David Britt, Yilin Hu   +6 more
doaj   +1 more source

A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway

Frontiers in Microbiology, 2023
The recent discovery of the archaeal modified mevalonate pathway revealed that the fundamental units for isoprenoid biosynthesis (isopentenyl diphosphate and dimethylallyl diphosphate) are biosynthesized via a specific intermediate, trans ...
Mutsumi Komeyama, Kohsuke Kanno, Hiroyuki Mino, Yoko Yasuno, Tetsuro Shinada, Tomokazu Ito, Hisashi Hemmi   +6 more
doaj   +1 more source

TusA influences Fe-S cluster assembly and iron homeostasis in E. coli by reducing the translation efficiency of Fur

Microbiology Spectrum
All sulfur transfer pathways have generally a l-cysteine desulfurase as an initial sulfur-mobilizing enzyme in common, which serves as a sulfur donor for the biosynthesis of numerous sulfur-containing biomolecules in the cell.
Paolo Olivieri, Arkadiuz Zupok, Tugba Yildiz, Jonathan Oltmanns, Angelika Lehmann, Ewelina Sokolowska, Aleksandra Skirycz, Volker Schünemann, Silke Leimkühler   +8 more
doaj   +1 more source