Results 11 to 20 of about 214,451 (303)
MRI of neurodegeneration with brain iron accumulation
Current Opinion in Neurology, 2020 Purpose of review The diagnosis of neurodegeneration with brain iron accumulation (NBIA) typically associates various extrapyramidal and pyramidal features, cognitive and psychiatric symptoms with bilateral hypointensities in the globus pallidus on iron-sensitive magnetic resonance images, reflecting the alteration of iron ...
Lehéricy, Stéphane +3 more
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Neurodegeneration with brain iron accumulation: an overview.
Iranian journal of child neurology, 2014 Neurodegeneration with brain iron accumulation (NBIA) is a group of neurodegenerative disorder with deposition of iron in the brain (mainly Basal Ganglia) leading to a progressive Parkinsonism, spasticity, dystonia, retinal degeneration, optic atrophy often accompanied by psychiatric manifestations and cognitive decline. 8 of the 10 genetically defined
TONEKABONI*, Seyed Hassan +1 more
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WDR45 Mutation Impairs the Autophagic Degradation of Transferrin Receptor and Promotes Ferroptosis
Frontiers in Molecular Biosciences, 2021 WDR45 is an autophagy-related protein that involves in the formation of autophagosome. Mutations in WDR45 lead to the impairment of autophagy which is associated with the human β-propeller protein-associated neurodegeneration (BPAN).
Qiuhong Xiong +6 more
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Dementia as a core clinical feature of a patient with aceruloplasminemia
Clinical Case Reports, 2022 Aceruloplasminemia is an autosomal recessive disease, caused by systemic iron accumulation due to mutations in the Ceruloplasmin gene. We report two Iranian siblings who have been diagnosed with aceruloplasminemia.
Farzad Ashrafi +3 more
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Ferroptosis in inflammatory arthritis: A promising future
Frontiers in Immunology, 2022 Ferroptosis is a kind of regulatory cell death (RCD) caused by iron accumulation and lipid peroxidation, which is characterized by mitochondrial morphological changes and has a complex regulatory network.
Siyuan Chang +4 more
doaj +1 more source
Cerebral Iron Deposition in Neurodegeneration
Biomolecules, 2022 Disruption of cerebral iron regulation appears to have a role in aging and in the pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron accumulation include reactive oxygen species generation, induction of ferroptosis,
Petr Dusek +4 more
doaj +1 more source
High fat diet subverts hepatocellular iron uptake determining dysmetabolic iron overload. [PDF]
PLoS ONE, 2015 Increased serum ferritin associated with mild hepatic iron accumulation, despite preserved upregulation of the iron hormone hepcidin, is frequently observed in patients with dysmetabolic overload syndrome (DIOS).
Paola Dongiovanni +10 more
doaj +1 more source
NeuroImage: Clinical, 2023 Objective: To investigate the metabolic pattern of different types of iron accumulation in multiple sclerosis (MS) lesions, and compare metabolic alterations within and at the periphery of lesions and newly emerging lesions in vivo according to iron ...
Alexandra Lipka +12 more
doaj +1 more source
THE ACCUMULATION OF IRON IN TUBERCULOUS AREAS [PDF]
Journal of Experimental Medicine, 1931 Repeated daily intravenous injections of ferric chloride solution are followed by an accumulation of iron in tuberculous areas of lungs. The iron accumulates in the caseous areas of tubercles and is demonstrable by the Prussian blue reaction. Quantitative determinations corroborate these results and show that the iron content of lung ...
V, Menkin, M F, Menkin
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New Players in Neuronal Iron Homeostasis: Insights from CRISPRi Studies
Antioxidants, 2022 Selective regional iron accumulation is a hallmark of several neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. The underlying mechanisms of neuronal iron dyshomeostasis have been studied, mainly in a gene-by-gene ...
Daniel A. Bórquez +3 more
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