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Iron Chelation in Local Infection [PDF]
Molecules, 2021 Iron is an essential element in multiple biochemical pathways in humans and pathogens. As part of the innate immune response in local infection, iron availability is restricted locally in order to reduce overproduction of reactive oxygen species by the ...
Cassidy Scott +3 more
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A Speciation Study on the Perturbing Effects of Iron Chelators on the Homeostasis of Essential Metal Ions. [PDF]
PLoS ONE, 2015 A number of reports have appeared in literature calling attention to the depletion of essential metal ions during chelation therapy on β-thalassaemia patients.
Guido Crisponi +6 more
doaj +11 more sources
Importance of iron chelation therapy [PDF]
Thalassemia Reports, 2011 It is necessary to remember that today patients have different options of chelation treatment, as desferrioxamine, deferiprone and deferasirox are available. However, a patient has to be compliant with treatments.
A. Varoğlu
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European Journal of Haematology, 2023 Iron overload is a pathological condition resulting from a congenital impairment of its regulation, increased intestinal iron absorption secondary to bone marrow erythroid hyperplasia, or a chronic transfusional regimen.
A. Bruzzese +11 more
semanticscholar +3 more sources
Advanced ScienceMyocardial infarction (MI), a consequence of coronary artery occlusion, triggers the degradation of ferritin, resulting in elevated levels of free iron in the heart and thereby inducing ferroptosis.
Qingbo Lv +9 more
doaj +2 more sources
Molecules, 2021 Pulse crop seed coats are a sustainable source of antioxidant polyphenols, but are typically treated as low-value products, partly because some polyphenols reduce iron bioavailability in humans.
Fatma M. Elessawy +3 more
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Red Blood Cell Transfusion Independence Following the Initiation of Iron Chelation Therapy in Myelodysplastic Syndrome [PDF]
Advances in Hematology, 2010 Iron chelation therapy is often used to treat iron overload in patients requiring transfusion of red blood cells (RBC). A 76-year-old man with MDS type refractory cytopenia with multilineage dysplasia, intermediate-1 IPSS risk, was referred when he ...
Maha A. Badawi +3 more
doaj +2 more sources
Chelator-facilitated removal of iron from transferrin: Relevance to combined chelation therapy [PDF]
, 2007 Current iron chelation therapy consists primarily of DFO (desferrioxamine), which has to be administered via intravenous infusion, together with deferiprone and deferasirox, which are orally-active chelators.
Devanur, LD +3 more
core +5 more sources
New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases
Pharmaceuticals, 2018 Iron chelation has been introduced as a new therapeutic concept for the treatment of neurodegenerative diseases with features of iron overload. At difference with iron chelators used in systemic diseases, effective chelators for the treatment of ...
Marco T. Nuñez, Pedro Chana-Cuevas
doaj +2 more sources
Haematologica, 2020 Iron overload due to red blood cell (RBC) transfusions is associated with morbidity and mortality in lower-risk myelodysplastic syndrome (MDS) patients. Many studies have suggested improved survival after iron chelation therapy (ICT), but valid data are ...
Marlijn Hoeks +32 more
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