Sex and Gender Differences in Iron Chelation [PDF]
BiomedicinesBackground/Objectives: In the absence of physiological mechanisms to excrete excessive iron, the administration of iron chelation therapy is necessary.
Sarah Allegra +3 more
doaj +3 more sources
A Speciation Study on the Perturbing Effects of Iron Chelators on the Homeostasis of Essential Metal Ions. [PDF]
PLoS ONE, 2015 A number of reports have appeared in literature calling attention to the depletion of essential metal ions during chelation therapy on β-thalassaemia patients.
Guido Crisponi +6 more
doaj +11 more sources
Journal of Internal Medicine, 1997 Desferrioxamine (DFX) remains the most effective and safe iron chelator for treatment of patients with transfusional iron overload. It is usually given by intermittent subcutaneous infusions for 8–12 h on 4–6 days weekly using a battery‐driven pump. Disposable balloon infusers provide a suitable method of giving continuous subcutaneous infusions with ...
A. V. Hoffbrand, B. Wonke
openalex +3 more sources
The Role of Iron Chelation Therapy in Colorectal Cancer: A Systematic Review on Its Mechanisms and Therapeutic Potential [PDF]
Cancer MedicineBackground Despite significant therapeutic advancements in recent decades, colorectal cancer (CRC) continues to exhibit high rates of mortality and morbidity.
Gihani Vidanapathirana +4 more
doaj +2 more sources
Nanosponge for Iron Chelation and Efflux: A Ferroptosis‐Inhibiting Approach for Myocardial Infarction Therapy [PDF]
Advanced ScienceMyocardial infarction (MI), a consequence of coronary artery occlusion, triggers the degradation of ferritin, resulting in elevated levels of free iron in the heart and thereby inducing ferroptosis.
Qingbo Lv +9 more
doaj +2 more sources
The importance of iron chelation and iron availability during PpIX-induced photodynamic therapy [PDF]
, 2015 This is the accepted version of the article. Please cite the published version which is available via the DOI link in this record.Background: Protoporphyrin IX (PpIX)-induced photodynamic therapy (PDT) is being utilised as a topical method of localised ...
Curnow, Alison, Pye, Andrew
core +3 more sources
Barriers to adherence to iron chelation therapy among adolescent with transfusion dependent thalassemia [PDF]
Frontiers in Pediatrics, 2022 Study backgroundThalassemia is the commonest genetic blood disorder in Malaysia which requires life-long blood transfusions. From a total of 7,984 thalassemia patients in Malaysia, adolescent age group account for the highest number of patients (2,680 ...
Rafaa Mohamed +3 more
doaj +2 more sources
Iron chelation beyond transfusion iron overload [PDF]
American Journal of Hematology, 2007 The effects of systemic iron overload in hereditary (e.g., classic HFE hemochromatosis) or acquired disorders (e.g., transfusion-dependent iron overload) are well known. Several other iron overload diseases, with an observed mild-to-moderate increase in iron in selected organs (e.g., the liver or the brain), or with "misdistribution" of iron within ...
Antonello Pietrangelo
openalex +4 more sources
Iron Chelation Property, Antioxidant Activity, and Hepatoprotective Effect of 6-Gingerol-Rich Ginger (Zingiber officinale) Extract in Iron-Loaded Huh7 Cells [PDF]
Plants, 2023 Iron is essential for numerous biological processes; however, an iron imbalance can contribute to a number of diseases. An excess of iron can accumulate in the body and subsequently induce the production of reactive oxygen species (ROS), leading to ...
Hataichanok Chuljerm +6 more
doaj +2 more sources
Iron Chelation in Patients with Myelodysplastic Syndromes and Myeloproliferative Neoplasms-Real-World Data from the German Noninterventional Study EXCALIBUR. [PDF]
J Clin Med, 2023 Schulz F +7 more
europepmc +3 more sources