Results 11 to 20 of about 1,030,253 (321)

Brazilian Thalassemia Association protocol for iron chelation therapy in patients under regular transfusion [PDF]

Revista Brasileira de Hematologia e Hemoterapia, 2013
In the absence of an iron chelating agent, patients with beta-thalassemia on regular transfusions present complications of transfusion-related iron overload.
Monica Pinheiro de Almeida Verissimo, Sandra Regina Loggetto, Antonio Fabron Junior, Giorgio Roberto Baldanzi, Nelson Hamerschlak, Juliano Lara Fernandes, Aderson da Silva Araujo, Clarisse Lopes de Castro Lobo, Kleber Yotsumoto Fertrin, Vasilios Antonios Berdoukas, Renzo Galanello   +10 more
doaj   +2 more sources

Combination therapies in iron chelation [PDF]

Thalassemia Reports, 2014
The availability of oral iron chelators and new non-invasive methods for early detection and treatment of iron overload, have significantly improved the life expectancy and quality of life of patients with b thalassemia major. However, monotherapy is not
Raffaella Origa
doaj   +3 more sources

Comparison Between Hesperidin, Coumarin, and Deferoxamine Iron Chelation and Antioxidant Activity Against Excessive Iron in the Iron Overloaded Mice

Frontiers in Neuroscience, 2022
Objective Iron accumulation in the brain leads to the development of Alzheimer’s and Parkinson’s diseases. Nowadays, iron chelation therapy is the best way to decrease the side effects of iron and amyloid plaques accumulation. Iron chelators are commonly
Mahdi Aalikhani, Yagoub Safdari, M. Jahanshahi, Mehrdad Alikhani, M. Khalili   +4 more
semanticscholar   +1 more source

Recent Advances in Iron Chelation and Gallium-Based Therapies for Antibiotic Resistant Bacterial Infections

International Journal of Molecular Sciences, 2021
Iron is essential for multiple bacterial processes and is thus required for host colonization and infection. The antimicrobial activity of multiple iron chelators and gallium-based therapies against different bacterial species has been characterized in ...
V. Vinuesa, M. McConnell
semanticscholar   +1 more source

Reversing oncogenic transformation with iron chelation

OncoTarget, 2021
Cancer cells accumulate iron to supplement their aberrant growth and metabolism. Depleting cells of iron by iron chelators has been shown to be selectively cytotoxic to cancer cells in vitro and in vivo.
Gina Abdelaal, S. Veuger
semanticscholar   +1 more source

Adherence to Iron Chelation Therapy and Its Determinants

International Journal of Hematology-Oncology and Stem Cell Research, 2021
Background: Thalassemia is a chronic disease requiring lifelong treatment. The adherence to regular iron chelation therapy is important to ensure complication-free survival and good quality of life. The study aim to assess the adherence to iron chelation
Sukhmani Sidhu, S. Kakkar, P. Dewan, N. Bansal, P. Sobti   +4 more
semanticscholar   +1 more source

Beta Thalassemia: New Therapeutic Options Beyond Transfusion and Iron Chelation

Drugs, 2020
Hemoglobinopathies are among the most common monogenic diseases worldwide. Approximately 1–5% of the global population are carriers for a genetic thalassemia mutation.
I. Motta, R. Bou-Fakhredin, A. Taher, M. Cappellini   +3 more
semanticscholar   +1 more source

Compliance and clinical benefit of deferasirox granule and dispersible tablet formulation in pediatric patients with transfusional iron overload: in a randomized, open-label, multicenter, phase II study

Haematologica, 2023
CALYPSO (clinicaltrials gov. Identifier: NCT02435212), a randomized, open-label, multicenter, phase II study evaluated the compliance, clinical benefits, and safety of deferasirox granules and dispersible tablets (DT) in pediatric patients with iron ...
Ali T. Taher, Yasser Wali, Maria Cecilia Cruz, Pimlak Charoenkwan, Yesim Aydinok, Olena Werner, Sameera Govindaraju, Fabian Romen, Vip Viprakasit   +8 more
doaj   +1 more source

Iron overload and chelation [PDF]

Hematology, 2005
Iron is one of the most common elements in nature. As a transition metal it is very efficient in electron transport and redox reactions. The proteins and enzymes in which iron is an essential component play a key role in respiration, energy production, detoxification of harmful oxygen species and cell replication.
Z. Ioav Cabantchik, Abraham M. Konijn, Chaim Hershko, Gabriela Link   +3 more
openaire   +2 more sources

Conservative iron chelation for neurodegenerative diseases such as Parkinson’s disease and amyotrophic lateral sclerosis

Journal of neural transmission, 2020
Focal iron accumulation associated with brain iron dyshomeostasis is a pathological hallmark of various neurodegenerative diseases (NDD). The application of iron-sensitive sequences in magnetic resonance imaging has provided a useful tool to identify the
D. Devos, Z. Cabantchik, C. Moreau, V. Danel, Laura Mahoney-Sánchez, H. Bouchaoui, F. Gouel, Anne-Sophie Rolland, J. Duce, J. Devedjian, Julien Marie Charlotte Jeanne Audrey Gwendal Stéphane Die Cassereau Bost Abrial Muller Olivier Le Masson Mat, Julien Cassereau, Marie Bost, Charlotte Abrial, Jeanne Muller, Audrey Olivier, G. Le Masson, Stéphane Mathis, Dieynaba Djigo, Sarah Bonabaud, Mathilde Deloire, S. Genestet, Elsa Menanteau, Pauline Bourgeois, Mathilde Lefilliatre, F. Viader, Mouloud Abrou, Damien Chavanne, Rachida Bari, N. Guy, Sophia Sickout Arondo, S. Rouvet, K. Beauvais, Mathilde Aidan, Olivier Madec, V. Danel-Brunaud, C. Tard, Marie Pleuvret, Valérie Santraine, Julie Moutarde, P. Couratier, G. Lautrette, Selma Machat, M. Penoty, O. Villeneuve, Clémence Labetoulle, J. Catteau, Emilien Bernard, J. Svahn, Camille Neuillet, S. Attarian, A. Grapperon, A. Verschueren, A. Parlanti, Nacime Heddadji, W. Camu, S. Pittion-Vouyovitch, Maud Michaud, Anne Chatelain, Isabelle Costa, M. Soriani, Arnaud Declemy, Carole Barre, F. Salachas, I. Kolev, Jean-Christophe Antoine, J. Camdessanché, Nathalie Dimier, Karine Férraud, Vincent Visneux, Marie-Cécile Fleury, P. Cintas, B. Acket, Magali Centelles, Véronique Hermet, P. Corcia, S. Beltran, S. Bakkouche   +77 more
semanticscholar   +1 more source