Results 21 to 30 of about 1,030,253 (321)
Iron chelation cancer therapy using hydrophilic block copolymers conjugated with deferoxamine
Cancer cells have high iron requirements due to their rapid growth and proliferation. Iron depletion using iron chelators has a potential in cancer treatment.
Kana Komoto+6 more
semanticscholar +1 more source
Iron(III) chelating resins-IV. Crosslinked copolymer beads of 1-(B-acrylamidoethyl)-3-hydroxy-2-methyl-4(1H)-pyridinone (AHMP) with 2-hydroxyethyl methacrylate (HEMA) [PDF]
Iron(III) chelating beads have been synthesized by copolymerization of 1-(ß-acrylamidoethyl)-3-hydroxy-2-methyl-4(IH)-pyridinone (AHMP) with 2-hydroxyethyl methacrylate (HEMA), and ethyleneglycol dimethacrylate (EGDMA) as the crosslinking agent.
Bantjes, A.+2 more
core +3 more sources
Iron chelation inhibits mTORC1 signaling involving activation of AMPK and REDD1/Bnip3 pathways
The mammalian target of rapamycin (mTOR) functions as two complexes (mTORC1 and mTORC2), regulating cell growth and metabolism. Aberrant mTOR signaling occurs frequently in cancers, so mTOR has become an attractive target for cancer therapy.
Chaowei Shang+5 more
semanticscholar +1 more source
Iron Chelators in Treatment of Iron Overload
Patients suffering from iron overload can experience serious complications. In such patients, various organs, such as endocrine glands and liver, can be damaged. Although iron is a crucial element for life, iron overload can be potentially toxic for human cells due to its role in generating free radicals. In the past few decades, there has been a major
Sarina Entezari+9 more
openaire +3 more sources
Background Plasma non-transferrin bound iron refers to heterogeneous plasma iron species, not bound to transferrin, which appear in conditions of iron overload and ineffective erythropoiesis.
Yesim Aydinok+3 more
doaj +1 more source
Predictors of Non-adherence to iron chelation therapy in pediatric thalassemia patients
Objective: This study was conducted to identify predictors of non-adherence to iron chelation therapy among children suffering from β-thalassemia major across different treatment regimens.
Muniba Kanwal+3 more
doaj +1 more source
Background Aceruloplasminemia is a rare genetic iron overload disorder, characterized by progressive neurological manifestations. The effects of iron chelation on neurological outcomes have only been described in case studies, and are inconsistent ...
L. Vroegindeweij+3 more
semanticscholar +1 more source
Study backgroundThalassemia is the commonest genetic blood disorder in Malaysia which requires life-long blood transfusions. From a total of 7,984 thalassemia patients in Malaysia, adolescent age group account for the highest number of patients (2,680 ...
Rafaa Mohamed+3 more
doaj +1 more source
The importance of iron chelation and iron availability during PpIX-induced photodynamic therapy [PDF]
This is the accepted version of the article. Please cite the published version which is available via the DOI link in this record.Background: Protoporphyrin IX (PpIX)-induced photodynamic therapy (PDT) is being utilised as a topical method of localised ...
Curnow, Alison, Pye, Andrew
core +1 more source
Desferrioxamine (DFX) remains the most effective and safe iron chelator for treatment of patients with transfusional iron overload. It is usually given by intermittent subcutaneous infusions for 8–12 h on 4–6 days weekly using a battery‐driven pump. Disposable balloon infusers provide a suitable method of giving continuous subcutaneous infusions with ...
A.V. Hoffbrand, B. Wonke
openaire +3 more sources