Results 101 to 110 of about 910,855 (274)

Neohesperidin Alleviates Ferroptosis in Doxorubicin‐Induced Cardiotoxicity via Mettl3‐m6A‐Nrf2 Signaling

Phytotherapy Research, EarlyView.
Neohesperidin alleviates doxorubicin‐induced cardiotoxicity by inhibiting METTL3‐mediated m6A modification of Nrf2 mRNA, thereby regulating Nrf2 and suppressing ferroptosis. ABSTRACT Doxorubicin (DOX) has antitumor efficacy, but its clinical application is restricted by multiple side effects, especially cardiotoxicity.
Ruijia Wen, Xin Dong, Haowen Zhuang, Yusheng Huang, Mengyuan Wang, Zhongzheng Zhang, Jinhong Chen, Wei Wang, Chun Li, Junyan Wang   +9 more
wiley   +1 more source

Efficacy of the lipid-soluble iron chelator 2,2′-dipyridyl against hemorrhagic brain injury

Neurobiology of Disease, 2012
Previous studies have indicated that 2,2′-dipyridyl, a lipid-soluble ferrous iron chelator, can reduce brain injury after cerebral ischemia and reduce cerebral vasospasm after subarachnoid hemorrhage.
He Wu, Tao Wu, Mingchang Li, Jian Wang
doaj   +1 more source

The mutagenesis of LL-37+Fe²⁺ combination is suppressed by the addition of an iron chelator.

, 2015
This supports the notion that iron is causal in increasing mutagenesis (A). In the same line, over-expression of Dps, a natural iron chelator in bacteria, also decreases the mutant frequency to rifampicin (B).
Olga Makarova (110386), Jens Rolff (220672), Alexandro Rodríguez-Rojas (326213), Uta Müller (575990)   +3 more
core   +1 more source

Butin Ameliorates Atherosclerosis by Regulating the TIMM13‐TIMM8A Complex to Alleviate Macrophage Ferroptosis

Phytotherapy Research, EarlyView.
The natural flavonoid Butin selectively targets the mitochondrial translocase subunit TIMM13 at residue Asn34, competitively disrupting the pathological TIMM13‐TIMM8A complex. This targeted engagement halts mitochondrial iron influx, reactivates the SLC7A11/GPX4 antioxidant cascade, and attenuates macrophage ferroptosis and foam cell formation ...
Dashuai Wang, Xinyi Yu, Mingjie Xie, Gongcheng Huang, Zhenxing Liang, Chen Huang, Hai Liu   +6 more
wiley   +1 more source

Trivalent Iron Chelator with Flavone Moiety: Synthesis and Pharmacological Properties

, 2010
2,2-bis(3,3,4,7-tetra hydroxyflavone) 1,3-dicyclohexyl carbamine, 3,3,4,7-tetra hydroxyflavone was obtained by the reaction of 3,3,4,7-tetra hydroxyflavone with 1,3-dicyclohexyl carbodiimid in presence of 4-dimethyl amino pyridine.
Doran, Figen, Karabulut, Sadet, YILDIZ, EMEL, Pinar, NESLİHAN, KARATAŞ, YUSUF   +4 more
core   +3 more sources

Multipurpose Iron-Chelating Ligands Inspired by Bioavailable Molecules

Biomolecules
Because of their capacity to bind metals, metal chelators are primarily employed for therapeutic purposes, but they can also find applications as colorimetric reagents and cleaning solutions as well as in soil remediation, electroplating, waste treatment,
Elena Cini, Guido Crisponi, Alessandra Fantasia, Rosita Cappai, Sofia Siciliano, Giuseppe Di Florio, Valeria M. Nurchi, Maddalena Corsini   +7 more
doaj   +1 more source

Recent developments centered on orally active iron chelators

Thalassemia Reports, 2014
Over the past twenty years there has been a growing interest in the orally active iron chelators, deferiprone and deferasirox, both have been extensively studied.
Robert Hider
doaj   +1 more source

Design, synthesis, and physicochemical and biological characterization of a new iron chelator of the family of hydroxychromenes

, 2002
Increasing evidence suggests that iron plays an important role in tissue damage both during chronic iron overload diseases (i.e., hemochromatosis) and when, in the absence of actual tissue iron overload, iron is delocalized from specific carriers or ...
Casolaro M, Ceccanti, A., Ceccanti A, Ferrali M, Bambagioni, S., Donati, D., PIETRANGELO, Antonello, Giorgi G, Zanello P, Pietrangelo, A., Ferrali, M., Bambagioni S, Donati D, Zanello, P., Casolaro, Mario, Fontani M, Giorgi, G., Laschi F, Fontani, M., Laschi, F.   +19 more
core   +1 more source

Dihydroartemisinin Engages NQO1 and Promotes Ferroptosis‐Related Oxidative Stress in Non‐Small Cell Lung Cancer

Phytotherapy Research, EarlyView.
Dihydroartemisinin Engages NQO1 and Promotes Ferroptosis‐Related Oxidative Stress in Non‐Small Cell Lung Cancer. ABSTRACT Dihydroartemisinin (DHA), a bioactive derivative of Artemisia annua L. (AAL), has shown antitumor activity in several malignancies, including non‐small cell lung cancer (NSCLC).
Xiuli Guo, Gan Tao, Mini Zhang, Linzhi Han, Sisi Yan, Chunsheng Wang, Jianguo Zhang, Xiaowan Guo, Kehua Hu, Yan Gong, Qiuji Wu, Conghua Xie   +11 more
wiley   +1 more source

Quantitative Imaging of Human Hemoglobin Binding to Staphylococcus aureus With Single‐Molecule Resolution

Small, EarlyView.
Single‐molecule localization microscopy is exploited to quantify the number of hemoglobin copies bound to specific receptors on S. aureus wall. This quantification supports the design of a photoactive derivative of hemoglobin able to photo‐inactivate S.
Pietro Delcanale, Andrea Mussini, Òscar Gulías, Montserrat Agut, Melissa Berni, Stefano Pongolini, Stefano Bruno, Alessandro Casnati, Santi Nonell, Cristiano Viappiani, Stefania Abbruzzetti   +10 more
wiley   +1 more source