Results 111 to 120 of about 910,855 (274)

Therapeutic Value of Combined Therapy with Deferasirox and Silymarin on Iron Overload in Children with Beta Thalassemia

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Background: Beta thalassemia is an inherited hemoglobin disorder resulting in chronic hemolytic anemia requiring life-long blood transfusion that cause iron overload. Silymarin plays a role as oral iron chelator and hepatoprotective agents in thalassemic
adel abd elhaleim hagag
doaj  

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Iron Chelation Reduces Intracellular Hydroxyl Radicals in Normal Human Dermal Fibroblasts Independently of Aging

Antioxidants
In cultured skin cells, decreases in antioxidant function and increases in intracellular free Fe2+ due to replicative aging have been reported. The Fenton reaction between Fe2+ and hydrogen peroxide is a threat to the skin because it produces hydroxyl ...
Kazunori Takemoto, Ami Ozaki, Yusuke Tanii, Masayuki Yagi, Masamitsu Ichihashi, Hideya Ando   +5 more
doaj   +1 more source

Effects of SIH and its analogs on iron-induced oxidation of ascorbic acid in a buffered solution (pH 7.4).

, 2014
Chelators were assayed at iron binding equivalents (IBE) of 0.1 (excess of Fe), 1 (iron-chelator complexes with a fully filled coordination sphere) and 3 (excess of free chelator).
Eliška Potůčková (5660962), Anna Jirkovská (660066), Kateřina Pravdíková (660063), Tereza Hergeselová (660065), Tomáš Šimůnek (2568280), Hana Jansová (5661277), Iva A. Špirková (660062), Jan Bureš (660060), Pavlína Hašková (2568277), Lucie Kolbabová (660064), Kateřina Hrušková (660059), Kateřina Vávrová (660067), Des R. Richardson (141026), Miloslav Macháček (5661280), Danuta S. Kalinowski (525221), Darius J. R. Lane (381080), Petra Kovaříková (660061), Vera Richardson (141000)   +17 more
core   +1 more source

m6A‐Related Regulation of Ferroptosis Contributes to Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis

Allergy, EarlyView.
This study uses human nasal epithelial cells and BALB/c mice to evaluate the role and molecular mechanism of ferroptosis in HDM‐induced AR, focusing on ferroptosis‐related responses and nasal epithelial barrier disruption. HDM exposure induces lipid peroxidation‐driven ferroptosis and epithelial barrier disruption.
Zehua Lin, Baoai Han, Qiang Xie, Aikebaier Tuohuti, Weisong Cai, Peng Zhou, Jiahao Meng, Qiuyang Fu, Zuhong He, Xiong Chen   +9 more
wiley   +1 more source

Metabolic remodelling in anthracycline cardiotoxicity: mechanisms and therapeutic insights

British Journal of Pharmacology, EarlyView.
Cardiac metabolic remodelling in anthracycline‐induced cardiomyopathy and metabolically oriented cardioprotective strategies. Schematic representation of substrate utilization, mitochondrial bioenergetic function and metabolic flexibility in the healthy heart, in anthracycline‐induced cardiomyopathy and under potential cardioprotective interventions ...
Giulia Guerra, Francesco Niro, Marco Mergiotti, Giovanni Gavatorta, Emilio Hirsch, Alessandra Ghigo   +5 more
wiley   +1 more source

Design, Synthesis, and Physicochemical and Biological Characterization of a New Iron Chelator of the Family of Hydroxychromenes

, 2016
Increasing evidence suggests that iron plays an important role in tissue damage both during chronic iron overload diseases (i.e., hemochromatosis) and when, in the absence of actual tissue iron overload, iron is delocalized from specific carriers or ...
Piero Zanello (1960180), Antonello Pietrangelo (3015918), Antonio Ceccanti (3015912), Marco Ferrali (3015915), Donato Donati (2112682), Gianluca Giorgi (1965745), Franco Laschi (2049280), Mario Casolaro (2511019), Sabrina Bambagioni (3015909), Marco Fontani (3015906)   +9 more
core   +1 more source

Mitochondrial iron homeostasis is required for azole tolerance in Candida albicans

The FEBS Journal, EarlyView.
In Candida albicans, the deletion of MRS4, which encodes a mitochondrial iron importer, abolishes fluconazole tolerance and increases cidality during cotreatment with the iron chelator BPS, without altering MIC or synergy. Fluconazole‐treated mutants exhibit increased mitochondrial depolarisation, fragmentation and reduced mitochondrial density.
Wouter Van Genechten, Gauthier Cornips, Martine De Jonge, Rudy Vergauwen, Patrick Van Dijck   +4 more
wiley   +1 more source

Banana fruit with nutritionally significant concentrations of iron and zinc: results from the field evaluation of genetically modified bananas (Musa spp.) in Australia

New Phytologist, EarlyView.
Iron and zinc distribution in wild‐type and transgenic Cavendish banana (Musa spp.) lines. Summary Iron deficiency remains a major public health problem in East Africa, where banana is a staple food for > 30 million people. This study investigated whether genetic modification could produce banana fruit containing nutritionally significant ...
Tal Cooper, Bulukani Mlalazi, Harjeet Khanna, Jennifer Kleidon, Phuong Hoang, Jeff Daniells, Wilberforce Tushemereirwe, Jesse Beasley, Alexander Johnson, Robert Harding, James L. Dale, Jean‐Yves Paul   +11 more
wiley   +1 more source

Topical Iron Chelator Therapy: Current Status and Future Prospects. [PDF]

Cureus, 2023
Ramadoss T, Weimer DS, Mayrovitz HN.
europepmc   +1 more source