Results 231 to 240 of about 910,855 (274)

Chelation of iron within the erythrocytic Plasmodium falciparum parasite by iron chelators

Molecular and Biochemical Parasitology, 1999
To examine the site of action of antimalarial iron chelators, iron ligands were added to control erythrocytes and to erythrocytes parasitized with Plasmodium falciparum, and the concentration of intracellular labile iron was monitored with the fluorescent probe, calcein.
M, Loyevsky, C, John, B, Dickens, V, Hu, J H, Miller, V R, Gordeuk   +5 more
openaire   +2 more sources

Iron Chelation Therapy

Iron overload is a serious complication associated with transfusion-dependent anemias and anemias characterized by ineffective erythropoiesis. Iron accumulation is toxic to many tissues, causing heart failure, cirrhosis, liver cancer, growth retardation, and multiple endocrine abnormalities.Chelation therapy aims to balance the rate of iron ...
Cappellini, Maria Domenica, Scaramellini, Natalia, Leoni, Simona, Motta, Irene   +3 more
openaire   +2 more sources

Combined iron chelation therapy

Annals of the New York Academy of Sciences, 2010
Patients with thalassemia major accumulate body iron over time as a consequence of continuous red blood cell transfusions which cause hepatic, endocrine, and cardiac complications. Despite the availability of three iron chelators, some patients fail to respond adequately to monotherapy with any of them. Combination therapy, consisting in the use of two
Galanello Renzo, Agus Annalisa, Campus Simona, DANJOU, FABRICE, Giardina Patricia J, Grady Robert W.   +5 more
openaire   +2 more sources

Iron Chelates in Soybean Exudate

Science, 1962
Soybean exudates contain iron compounds which can be separated electrophoretically into anodic bands and eluted with water. Chromatography of the water extracts separated iron from chelating agents which were identified as malic acid and malonic acid. Hence organic acids seem to function in the translocation of iron in plants.
L O, Tiffin, J C, Brown
openaire   +2 more sources

Iron Chelators for the Treatment of Cancer

Current Medicinal Chemistry, 2012
The study of iron chelators as anti-tumor agents is still in its infancy. Iron is important for cellular proliferation and this is demonstrated by observations that iron-depletion results in cell cycle arrest and also apoptosis. In addition, many iron chelators are known to inhibit ribonucleotide reductase, the iron-containing enzyme that is the rate ...
Yu, Yu, Gutierrez, E., Kovacevic, Z., Saletta, F., Obeidy, P., Rahmanto, Y., Richardson, D.   +6 more
openaire   +3 more sources

Iron Amino Acid Chelates

International Journal for Vitamin and Nutrition Research, 2004
Iron amino acid chelates, such as iron glycinate chelates, have been developed to be used as food fortificants and therapeutic agents in the prevention and treatment of iron deficiency anemia. Ferrous bis-glycine chelate (FeBC), ferric tris-glycine chelate, ferric glycinate, and ferrous bis-glycinate hydrochloride are available commercially.
Eva, Hertrampf, Manuel, Olivares
openaire   +2 more sources

Iron Toxicity and Chelation Therapy

International Journal of Hematology, 2002
Iron is an essential mineral for normal cellular physiology, but an excess can result in cell injury. Iron in low-molecular-weight forms may play a catalytic role in the initiation of free radical reactions. The resulting oxyradicals have the potential to damage cellular lipids, nucleic acids, proteins, and carbohydrates; the result is wide-ranging ...
Robert S, Britton, Katherine L, Leicester, Bruce R, Bacon   +2 more
openaire   +2 more sources

Iron Chelation in Chemotherapy

2003
Publisher Summary This chapter discusses the way accumulation of excessive amounts of iron results in the loss of tissue and organ functions. Excessive iron in specific tissue sites promotes infection, neoplasia, cardiomyopathy, arthropathy, and an array of endocrine and neurodegenerative diseases.
openaire   +2 more sources

Iron Chelation for Iron Overload in Thalassemia.

Metal ions in life sciences, 2019
This chapter is devoted to the chelation treatment of transfusion-dependent thalassemia patients. After a brief overview on the pathophysiology of iron overload and on the methods to quantify it in different organs, the chelation therapy is discussed, giving particular attention to the chemical and biomedical requisites.
Guido Crisponi, Valeria Marina Nurchi, Joanna I. Lachowicz   +2 more
openaire   +2 more sources

Update on Iron Chelators in Thalassemia

Hematology, 2010
AbstractOver the past four decades, there have been dramatic improvements in survival for patients with thalassemia major due in large measure to improved iron chelators. Two chelators are approved for use in the United States and Canada, parenteral deferoxamine and oral deferasirox.
openaire   +2 more sources