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CRC Critical Reviews in Clinical Laboratory Sciences, 1988
Because of the catalytic action of iron in one-electron redox reactions, it has a key role in the formation of harmful oxygen derivatives and production of peroxidative damage to vital cellular structures. The clinical manifestations of iron overload may be prevented and even reversed by the effective administration of the iron-chelating drug ...
Chaim Hershko +2 more
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Because of the catalytic action of iron in one-electron redox reactions, it has a key role in the formation of harmful oxygen derivatives and production of peroxidative damage to vital cellular structures. The clinical manifestations of iron overload may be prevented and even reversed by the effective administration of the iron-chelating drug ...
Chaim Hershko +2 more
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Biochimica et Biophysica Acta, 1963
Abstract Reducing sugars and polyols are shown to form soluble stable complexes with a series of metal ions at alkaline pH. Several properties of an iron-fructose complex have been studied. The specific conditions of pH and concentrations of iron and fructose necessary for complex formation are described. Evidence for the existence of the complex is (
P J, CHARLEY +3 more
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Abstract Reducing sugars and polyols are shown to form soluble stable complexes with a series of metal ions at alkaline pH. Several properties of an iron-fructose complex have been studied. The specific conditions of pH and concentrations of iron and fructose necessary for complex formation are described. Evidence for the existence of the complex is (
P J, CHARLEY +3 more
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Hydroxyquinolines as Iron Chelators
Current Medicinal Chemistry, 2003The interest in synthetic siderophore mimics includes therapeutic applications (iron chelation therapy), the design of more effective agents to deliver Fe to plants and the development of new chemical tools for studies of iron metabolism and for a better understanding of iron assimilation processes in living systems.
J-L, Pierre, P, Baret, G, Serratrice
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1994
The design of an orally active, non-toxic, selective iron chelator has been a goal of many medical chemists over the past twenty years. Naturally occurring siderophores provide excellent models for such molecules, indeed, desferrioxamine has been and still remains an extremely useful iron chelator.
R C, Hider +3 more
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The design of an orally active, non-toxic, selective iron chelator has been a goal of many medical chemists over the past twenty years. Naturally occurring siderophores provide excellent models for such molecules, indeed, desferrioxamine has been and still remains an extremely useful iron chelator.
R C, Hider +3 more
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Journal of the American Medical Association, 1958
Administration of effective doses of iron in the treatment of iron deficiency anemia is complicated by the fact that iron compounds are not innocuous. Toxicity experiments on dogs and rabbits are here summarized; they showed that the concentration of iron attained in the animal's serum determined the severity of the acute symptoms.
M, FRANKLIN +3 more
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Administration of effective doses of iron in the treatment of iron deficiency anemia is complicated by the fact that iron compounds are not innocuous. Toxicity experiments on dogs and rabbits are here summarized; they showed that the concentration of iron attained in the animal's serum determined the severity of the acute symptoms.
M, FRANKLIN +3 more
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Current Opinion in Hematology, 2014
This review provides an update on advances in the area of iron chelation therapy, including new indications and uses of currently available agents, and preliminary data on potential new agents in development.Two new oral agents, deferasirox and deferiprone, have become available in the last 8 years.
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This review provides an update on advances in the area of iron chelation therapy, including new indications and uses of currently available agents, and preliminary data on potential new agents in development.Two new oral agents, deferasirox and deferiprone, have become available in the last 8 years.
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Iron chelators and iron toxicity
Alcohol, 2003Iron chelation may offer new approaches to the treatment and prevention of alcoholic liver disease. With chronic excess, either iron or alcohol alone may individually injure the liver and other organs. In combination, each exaggerates the adverse effects of the other.
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2002
Iron overload is a serious clinical condition which can be largely prevented by the use of iron-specific chelating agents. Desferrioxamine-B(1)the most widely used iron chelator in haematology over the past thirty years, has a major disadvantage of being orally inactive’.
Liu, Z D, Liu, D Y, Hider, R C
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Iron overload is a serious clinical condition which can be largely prevented by the use of iron-specific chelating agents. Desferrioxamine-B(1)the most widely used iron chelator in haematology over the past thirty years, has a major disadvantage of being orally inactive’.
Liu, Z D, Liu, D Y, Hider, R C
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Current Opinion in Hematology, 1995
Iron chelation therapy is essential to prevent death from cardiac toxicity in patients with thalassemia major or other severe refractory anemias who need regular blood transfusions. Iron chelating drugs also have potential for clinical use as antiproliferative agents in neoplastic diseases and to reduce free radical-induced tissue damage in rheumatoid ...
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Iron chelation therapy is essential to prevent death from cardiac toxicity in patients with thalassemia major or other severe refractory anemias who need regular blood transfusions. Iron chelating drugs also have potential for clinical use as antiproliferative agents in neoplastic diseases and to reduce free radical-induced tissue damage in rheumatoid ...
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Hematology/Oncology Clinics of North America, 2008
Effective chelation therapy can prevent or reverse organ toxicity related to iron overload, yet cardiac complications and premature death continue to occur, largely related to difficulties with compliance in patients who receive parenteral therapy. The use of oral chelators may be able to overcome these difficulties and improve patient outcomes.
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Effective chelation therapy can prevent or reverse organ toxicity related to iron overload, yet cardiac complications and premature death continue to occur, largely related to difficulties with compliance in patients who receive parenteral therapy. The use of oral chelators may be able to overcome these difficulties and improve patient outcomes.
openaire +3 more sources