Polyphosphate Functions In Vivo as an Iron Chelator and Fenton Reaction Inhibitor. [PDF]
mBio, 2020 Beaufay F +5 more
europepmc +1 more source
Arabidopsis thaliana BOLA proteins, new actors in plant growth and iron homeostasis
The Plant Journal, Volume 128, Issue 3, November 2026.SUMMARY The universal iron–sulfur (Fe‐S) clusters embedded in proteins support numerous fundamental biological processes. However, many proteins involved in Fe‐S assembly machineries remain poorly characterized in plants. Here, we revealed that BOLA1 and BOLA4, two members of the BOLA family previously described as Fe‐S assembly factors in various ...
Maël Taupin‐Broggini +7 more
wiley +1 more source
Evaluation of the performance and safety of adding the iron chelator MEX-CD1 to dialysate during continuous veno-venous haemodialysis for removing excess labile iron in intensive care patients with sepsis-associated acute kidney injury - the Iron in Intensive Care trial (<i>IRON-I.C</i>.): protocol for a phase I-II randomised crossover pilot study. [PDF]
BMJ OpenCouturier A +6 more
europepmc +1 more source
Investigation of the DSF/Cu Reaction Using HR LCMS and Reactivity Studies
ChemBioChem, Volume 27, Issue 20, 28 October 2026.The generation of Cu(II)bis(diethyldithiocarbamate) from the combination of disulfiram and Cu salts, as used in many cuprototic cancer studies, is examined using high‐resolution liquid chromatography‐mass spectroscopy. By monitoring the reaction at different sampling times to determine reaction intermediates and the addition of adduct‐forming traps, a ...
Jordan Lyons, Patrick J. Farmer
wiley +1 more source
Iron Chelator Deferiprone Restores Iron Homeostasis and Inhibits Retinal Neovascularization in Experimental Neovascular Age-Related Macular Degeneration. [PDF]
Invest Ophthalmol Vis SciXu Y +10 more
europepmc +1 more source
Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers
ChemMedChem, Volume 21, Issue 20, 28 October 2026.Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley +1 more source
A Comparative Study on the Complexation of the Anticancer Iron Chelator VLX600 with Essential Metal Ions. [PDF]
Inorg ChemPósa V +11 more
europepmc +1 more source
Deferoxamine, deferasirox, and deferiprone triple iron chelator combination therapy for transfusion-dependent β-thalassaemia with very high iron overload: a randomised clinical trial. [PDF]
Lancet Reg Health Southeast AsiaPremawardhena A +7 more
europepmc +1 more source
The FASEB Journal, Volume 40, Issue 19, 15 October 2026.This graphical abstract summarizes gestational changes in placental iron homeostasis and their relationship to ferroptosis‐associated molecular features. In trophoblast cells, experimentally induced sublethal iron‐dependent redox perturbation modulates migration and invasion without causing overt ferroptotic cell death, whereas iron chelation or ...
Wenxin Jiang +7 more
wiley +1 more source
Nickel‐Substituted Rubredoxin Undergoes Demetallation Upon Reaction With Nitric Oxide and Nitroxyl
ChemBioChem, Volume 27, Issue 19, 14 October 2026.Rubredoxin is a thermally stable thiolate iron‐bound protein that can be prepared as a nickel‐substituted one. This nickel protein showed sensitivity to reaction with NO and HNO donors, causing its demetallation. Notably, these reactions exhibit spectroscopic profiles in the ultraviolet–visible and fluorescence with potential bioanalytical use.
Eduardo H. S. Sousa +8 more
wiley +1 more source