Results 181 to 190 of about 910,855 (274)

VLX600, an anticancer iron chelator, exerts antimicrobial effects on <i>Mycobacterium abscessus</i> infections. [PDF]

Microbiol Spectr
Oh J, Choi S, Seo H, Kim DH, Kim H, Lee D, Jang J, Jung S, Lee J-Y, Kim Z, Yim J-J, Kwak N, Kim B-J.   +12 more
europepmc   +1 more source

Biofilm-specific uptake of a 4-pyridone-based iron chelator by Pseudomonas aeruginosa. [PDF]

Biometals, 2021
Houshmandyar S, Eggleston IM, Bolhuis A.
europepmc   +1 more source

The role of iron in normal and impaired testicular function

Andrology, Volume 14, Issue 8, Page 2373-2387, November 2026.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Impact of Sappan Wood Extract as Iron Chelator Adjuvant on Iron Concentration and Macrophage Polarization in Rat Spleen. [PDF]

Iran J Med Sci
Ghozali M, Safitri R, Khristian E, Ainni AP, Kuntana YP, Bashari MH, Purnama JN.   +6 more
europepmc   +1 more source

Iron Chelator Induces Apoptosis in Osteosarcoma Cells by Disrupting Intracellular Iron Homeostasis and Activating the MAPK Pathway. [PDF]

Int J Mol Sci, 2021
Xue Y, Zhang G, Zhou S, Wang S, Lv H, Zhou L, Shang P.   +6 more
europepmc   +1 more source

DBT Modulates Copper‐Dependent Cuproptosis‐Related Injury in Experimental Alcoholic Cardiomyopathy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Alcoholic cardiomyopathy (ACM) is a severe cardiovascular complication of chronic alcohol consumption, but its underlying mechanisms remain incompletely understood. Cuproptosis is a recently identified copper‐dependent form of regulated cell death; however, its role in ACM remains unclear.
Zhihao Pan, Liuming Gao, Yi Ling, Xianfeng Cen   +3 more
wiley   +1 more source

The cell-permeable iron chelator M606 inhibits MYCN-driven neuroblastoma via an E2F3-mediated response. [PDF]

Proc Natl Acad Sci U S A
Pandher R, Xue C, Gamble LD, Milazzo G, Di Giacomo S, Murray J, Cheung L, Ferrucci F, Palombo M, Purgato S, Burkhart CA, Fedtsova N, Gleiberman AS, Purmal AA, Korotchkina L, Nikiforov MA, Makarov SS, Telfer TJ, Codd R, Marshall GM, Scott DA, Osterman AL, Gudkov AV, Perini G, Haber M, Norris MD.   +25 more
europepmc   +1 more source

Systemic administration of a pharmacologic iron chelator reduces cartilage lesion development in the Dunkin-Hartley model of primary osteoarthritis. [PDF]

Free Radic Biol Med, 2022
Burton LH, Afzali MF, Radakovich LB, Campbell MA, Culver LA, Olver CS, Santangelo KS.   +6 more
europepmc   +1 more source

HuR Confers Resistance of Hepatocellular Carcinoma to Lenvatinib by Inhibiting Ferroptosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT This study aim to explore whether human antigen R (HuR) inhibits ferroptosis confers resistance to lenvatinib in hepatocellular carcinoma (HCC). Bioinformatics analysis and immunofluorescence detection of 30 HCC tissue samples were used to verify the clinical correlation between HuR and glutathione peroxidase 4 (GPX4), establish a lenvatinib ...
Siren Feng, Fang Wang, Huayi Wu, Xinran Lin, Xue Qi, Kun Liu, Qiushi Yin, Bo Lin, Mengsen Li, Mingyue Zhu   +9 more
wiley   +1 more source

Elucidating the High Affinity Copper(II) Complexation by the Iron Chelator Deferasirox Provides Therapeutic and Toxicity Insight. [PDF]

ChemMedChem
Orta Rivera AM, Landrau Correa LA, Schiavone-Chamorro SL, Rankins M, Pérez Otero MV, Benjamín-Rivera JA, Vega Aponte JA, Ebenki VB, Vargas Figueroa AI, Astashkin AV, Fernández-Vega L, Tinoco AD.   +11 more
europepmc   +1 more source