Results 161 to 170 of about 910,855 (274)

Differential recovery of macrophage iron deficiency by oral iron formulations determines inflammation and autocrine hepcidin production in iron‐deficiency anemia

HemaSphere, Volume 10, Issue 11, November 2026.
Abstract Exposure of macrophages to iron has been implicated in sterile inflammation through reactive oxygen species (ROS)‐dependent cell pro‐inflammatory activation. Here, we compare the effect of the commonly used oral iron salt, iron sulfate (FeSO4), with that of an innovative formulation, sucrosomial® iron (SI), on the iron status and inflammatory ...
Ada Antypiuk, Michela Asperti, Richa Sharma, Shobana Navaneethabalakrishnan, Navdeep Jhita, Quentinn Pearce, James E. Cox, Elisa Brilli, Germano Tarantino, Francesca Vinchi   +9 more
wiley   +1 more source

Iron Chelator or Iron Supplement Consumption in COVID-19? The Role of Iron with Severity Infection. [PDF]

Biol Trace Elem Res, 2022
Bastin A, Shiri H, Zanganeh S, Fooladi S, Momeni Moghaddam MA, Mehrabani M, Nematollahi MH.   +6 more
europepmc   +1 more source

Synergistic Promotion of Ferroptosis in Cardiomyocytes by Tumor Cell Secretory Factors and PD‐1 Blockade

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Tumor‐derived exosomal factors prime cardiomyocytes for ferroptosis by suppressing the GPX4–SLC7A11–Nrf2 antioxidant axis, depleting glutathione, and promoting iron‐dependent lipid peroxidation. While PD‐1 blockade alone induces only mild oxidative stress, it acts synergistically with tumor signals to markedly amplify ferroptosis, leading to ...
Xiaohua Ma, Xiufeng Li, Fuchao Qu, Hao Cheng, Yifei Liu, Chenhui Liu   +5 more
wiley   +1 more source

The in vitro activity of iron chelator deferiprone against Candida (Candidozyma) auris in combination with antifungal agents. [PDF]

Med Mycol
Tóth Z, Farkas B, Majoros L, Jakab Á, Borman AM, Varga I, Tóth PR, Kovács R.   +7 more
europepmc   +1 more source

Synthesis, Cytotoxic Activity, mRNA Expression, Total Oxidant and Antioxidant Status, and Molecular Modeling Studies of Novel Schiff Base–Thiosemicarbazone Hybrids

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
In this study, new Schiff base‐derived compounds were synthesized, and their structures were confirmed by FT‐IR, 1H‐NMR, 13C‐NMR, and HRMS analyses. The cytotoxic effects of the compounds on a prostate cancer cell line (PC3) were investigated, and it was determined that the compounds NZ10, NZ9, NZ7, and NZ4, in particular, exhibited potent anticancer ...
Anber M Anber, Mehmet Özbay, İlhan Özer İlhan, Hüseyin Kekeçmuhammed, Rıfat Emin Bora, Emin Saripinar, Yalçın Erzurumlu, Muhammed Tilahun Muhammed, Sadeq K. Alhag, Lamya Ahmed Alkeridis, Senem Akkoc   +10 more
wiley   +1 more source

Mechanistic insights into the antiproliferative effect of the redox-active iron chelator Dp44mT on multiple myeloma cell lines. [PDF]

Hematol Transfus Cell Ther
Sharma A, Pathangey L, Chirackal SS, Mangalaparthi KK, Pandey A, Fonseca R, Swaminathan S.   +6 more
europepmc   +1 more source

Analysis of Renal Cell Carcinoma Cell Response to the Enhancement of 5-aminolevulinic Acid-mediated Protoporphyrin IX Fluorescence by Iron Chelator Deferoxamine^†. [PDF]

Photochem Photobiol, 2023
Howley R, Mansi M, Shinde J, Restrepo J, Chen B.   +4 more
europepmc   +1 more source

Neointimal Hyperplasia and Restenosis: Epidemiology, Pathophysiology, Animal Models, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
The overall graphical diagram to summarize the pathological characteristics, pathogenesis, clinical manifestation, preclinical animal models, diagnostic methods, and intervention strategies for neointimal hyperplasia. Neointimal hyperplasia results from excessive proliferation and intimal migration of vascular smooth muscle cells (VSMCs) in the ...
Kaixu Wang, Daiyu Zhang, Yu Hu, Yixin Zhao, Xinling Wang, Long Jiang, Meixiu Jiang   +6 more
wiley   +1 more source

The iron chelator pulcherriminic acid mediates the light response in Bacillus subtilis biofilms. [PDF]

Nat Commun
Kobayashi K, Kurata R, Tohge T.
europepmc   +1 more source

Sepsis: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 11, November 2026.
Sepsis remains a major global health burden characterized by substantial geographical heterogeneity and a considerable disease burden in China. Its pathophysiology reflects an interconnected network involving excessive inflammation, oxidative stress, immune imbalance and immunoparalysis, mitochondrial damage, endothelial injury, gut dysbiosis ...
Guang‐Tao Pan, Yu Deng, Lin‐Rui Ma, Yu‐Tong Li, Yu Qian, Yi‐Hua Ma, Hai‐Wei Rao, Yi‐Zhun Zhu, Pei‐Yu Yan   +8 more
wiley   +1 more source