Results 151 to 160 of about 910,855 (274)

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Thymosin β4 Is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis. [PDF]

Int J Mol Sci, 2022
Lachowicz JI, Pichiri G, Piludu M, Fais S, Orrù G, Congiu T, Piras M, Faa G, Fanni D, Dalla Torre G, Lopez X, Chandra K, Szczepski K, Jaremko L, Ghosh M, Emwas AH, Castagnola M, Jaremko M, Hannappel E, Coni P.   +19 more
europepmc   +1 more source

Correlations of in vitro and in vivo metabolism and pharmacokinetics of a new iron chelator, APOCP363, in the normal and iron-overload rat

, 2001
grantor: University of Toronto'In vitro' and 'in vivo' drug metabolism and pharmacokinetics (DM/PK) of a new iron chelator, APOCP363, were assessed in both normal and iron-overload rats, where the later represented a model ...
Guo, Feng
core   +1 more source

Programmed Interfacial Phase Separation for Spatiotemporal Fungicide Delivery via Tunable Micro/Nano Architectures

Advanced Science, Volume 13, Issue 61, 3 November 2026.
ABSTRACT Translating dynamic liquid‐liquid phase separation into robust solid‐state architectures remains a challenge in materials engineering. Here, we report a composition‐driven interfacial assembly strategy that couples supramolecular coacervation with metal‐phenolic coordination to engineer tunable fungicide carriers.
Rui Zhang, Tongfang Jing, Leiming He, Kaidi Cui, Yuying Song, Xuewei Mao, Lidong Cao, Lin Zhou   +7 more
wiley   +1 more source

Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions. [PDF]

Cancers (Basel), 2022
Jakobsson AW, Kundu S, Guo J, Chowdhury A, Zhao M, Lindell E, Bergsten P, Swartling FJ, Sjöblom T, Zhang X.   +9 more
europepmc   +1 more source

Selective AUTAC‐mediated ATP7B degradation unlocks cuproptosis vulnerability in pancreatic ductal adenocarcinoma

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
ATP7B is aberrantly upregulated in PDAC cells, contributing to the maintenance of copper homeostasis. We designed ATAUTAC, a targeted autophagy‐dependent degradation molecule that selectively eliminates ATP7B. By disrupting copper balance, ATAUTAC sensitizes PDAC cells to cuproptosis, thereby amplifying copper‐induced metabolic stress and effectively ...
Zihan Zhang, Min Li, Jiale Feng, Jian‐Ang Li, Lei Zhang   +4 more
wiley   +1 more source

The Effect of Long-Term Iron Chelator Therapy on Serum Levels of Hepcidin and Ferritin in Patients with Thalassemia Major and Intermediate. [PDF]

Indian J Hematol Blood Transfus, 2022
Eshagh Hossaini SK, Haeri MR, Seif F.
europepmc   +1 more source

Food Properties, Bioactive Components, and Human Factors as Determinants of Low Nutrient Supply From Foods Can Be Improved With Adequate Nutritional Strategies

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Nutrient adequacy depends on food composition, bioaccessibility, absorption, physiological utilization, dietary access, supply stability, etc. Food properties, human health, agricultural conditions, and socioeconomic barriers influence nutrient delivery.
Chinaza Godswill Awuchi
wiley   +1 more source

Iron Chelator Transmetalative Approach to Inhibit Human Ribonucleotide Reductase. [PDF]

JACS Au, 2021
Gaur K, Pérez Otero SC, Benjamín-Rivera JA, Rodríguez I, Loza-Rosas SA, Vázquez Salgado AM, Akam EA, Hernández-Matias L, Sharma RK, Alicea N, Kowaleff M, Washington AV, Astashkin AV, Tomat E, Tinoco AD.   +14 more
europepmc   +1 more source

Eggshell Waste Valorization: Nutritional Composition, Functional Properties, and Industrial Applications

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
This review aims to summarize the composition and functional roles of the shell and membrane, compare conventional, thermal, chemical, mechanochemical, microwave‐assisted, and biological processing routes, link processing conditions to material properties and application performance, distinguish laboratory proof‐of‐concept from pilot, semi‐industrial ...
Farhang Hameed Awlqadr, Iffat Ullah, Muhammad Tayyab Arshad, Mamoona Shehzadi, Ali Ikram, Meerab Sajid, Mohammed Ali Al‐Duais, Md. Sakhawot Hossain   +7 more
wiley   +1 more source