Results 11 to 20 of about 479,648 (301)

Ironing out the details: Untangling dietary iron and genetic background in diabetes [PDF]

, 2018
The search for genetic risk factors in type-II diabetes has been hindered by a failure to consider dietary variables. Dietary nutrients impact metabolic disease risk and severity and are essential to maintaining metabolic health.
Lawson, Heather A, Miranda, Mario A
core   +2 more sources

Ferroportin Is Essential for Iron Absorption During Suckling, But Is Hyporesponsive to the Regulatory Hormone HepcidinSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Previous studies have suggested that iron absorption in suckling mammals is refractory to stimuli that normally would decrease absorption in adults.
David M. Frazer, Sarah J. Wilkins, Deepak Darshan, Cornel S.G. Mirciov, Linda A. Dunn, Gregory J. Anderson   +5 more
doaj   +1 more source

Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells

Cell Death and Disease, 2022
Brain iron dysregulation associated with aging is closely related to motor and cognitive impairments in neurodegenerative diseases. The regulation of iron traffic at the blood-brain barrier (BBB) is crucial to maintain brain iron homeostasis.
Linhao You, Pan-Pan Yu, Tianyu Dong, Wenhuan Guo, Shiyang Chang, Bingjie Zheng, Yunzhe Ci, Fudi Wang, Peng Yu, Guofen Gao, Yan-Zhong Chang   +10 more
doaj   +1 more source

UV-light-driven prebiotic synthesis of iron–sulfur clusters [PDF]

, 2017
Iron–sulfur clusters are ancient cofactors that play a fundamental role in metabolism and may have impacted the prebiotic chemistry that led to life.
Bonfio, Claudia, Evans, David J., Jin, Lin, Mansy, Sheref, Mansy, Sheref S., Sasselov, Dimitar, Sasselov, Dimitar D., Scintilla, Simone, Shah, Sachin, Sutherland, John, Sutherland, John D., Szostak, Jack, Szostak, Jack W., Valer, Luca   +13 more
core   +1 more source

Overexpression of Mitochondrial Ferritin Enhances Blood–Brain Barrier Integrity Following Ischemic Stroke in Mice by Maintaining Iron Homeostasis in Endothelial Cells

Antioxidants, 2022
Blood–brain barrier (BBB) breakdown, a characteristic feature of ischemic stroke, contributes to poor patient outcomes. Brain microvascular endothelial cells (BMVECs) are a key component of the BBB and dysfunction or death of these cells following ...
Peina Wang, Qianqian Ren, Mengtong Shi, Yuanyuan Liu, Huiyuan Bai, Yan-Zhong Chang   +5 more
doaj   +1 more source

Iron metabolism in trypanosomatids, and its crucial role in infection. [PDF]

, 2010
Iron is almost ubiquitous in living organisms due to the utility of its redox chemistry. It is also dangerous as it can catalyse the formation of reactive free radicals - a classical double-edged sword.
Kelly, JM, Taylor, MC
core   +1 more source

Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis

Cell Death and Disease, 2021
Ischaemic stroke is becoming the most common cerebral disease in aging populations, but the underlying molecular mechanism of the disease has not yet been fully elucidated.
Peina Wang, Yanmei Cui, Qianqian Ren, Bingqi Yan, Yashuo Zhao, Peng Yu, Guofen Gao, Honglian Shi, Shiyang Chang, Yan-Zhong Chang   +9 more
doaj   +1 more source

Nitrate-Dependent Iron Oxidation: A Potential Mars Metabolism [PDF]

, 2018
This work considers the hypothetical viability of microbial nitrate-dependent Fe2+ oxidation (NDFO) for supporting simple life in the context of the early Mars environment.
Abramov, Amils, Anand, Arevalo, Arnold, Arvidson, Bauermeister, Benz, Bibring, Bridges, Bridges, Bruce, Busigny, Byrne-Bailey, Cabrol, Canfield, Carlson, Carlson, Carr, Chakraborty, Chakraborty, Changela, Charlou, Chassefière, Chastain, Chaudhuri, Chevrier, Cockell, Cockell, Cockell, Comeau, Czaja, Dartnell, Edwards, Edwards, Edwards, Ehlmann, Ehlmann, Ehlmann, Ehrenreich, Emerson, Emerson, Emerson, Etique, Ettwig, Fassett, Filiberto, Fisk, Formisano, Fowler, Fox, Fox, Fox-Powell, Frydenvang, Gauger, Gendrin, Glavin, Grady, Gronstal, Grotzinger, Grotzinger, Hafenbradl, Hecht, Hedrich, Hicks, Hoefen, Hoehler, Hoppert, Hurowitz, Ilbert, Ionescu, Irwin, Jakosky, Jepsen, Johnson, Kappler, Kappler, Kappler, King, Kish, Klueglein, Klueglein, Konhauser, Konn, Kounaves, Kumaraswamy, Lack, Lalonde, Lanza, Laufer, Lopez-Reyes, Lovley, Lovley, Madigan, Mahaffy, Malin, Mangold, Manning, Martin, Martín-Torres, Marzo, McSween, McSween, Michalski, Millero, Ming, Ming, Miot, Miot, Miot, Miot, Miot, Miot, Miot, Miot, Mirvaux, Montoya, Morgan, Morris, Morris, Morris, Muehe, Myers, Nachon, Navarro-González, Nealson, Nie, Nixon, Nixon, Nixon, Oren, Osinski, Palucis, Pantke, Parnell, Pirajno, Popa, Raghoebarsing, Raiswell, Ramirez, Rampe, Rampe, Reimers, Revsbech, Roden, Santelli, Schieber, Schuerger, Schwenzer, Schwenzer, Schädler, Sephton, Sholes, Smith, Smith, Squyres, Squyres, Squyres, Steele, Stern, Stern, Stevens, Straub, Straub, Straub, Strohm, Summers, Summers, Summers, Sutter, Toporski, Tosca, Tosca, Tuff, Vaniman, Visscher, Wacey, Weber, Weber, Weber, Webster, Welhan, Wheat, Williams, Yen, Yen   +185 more
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Insights into molecular mechanisms of disease in Neurodegeneration with Brain Iron Accumulation; unifying theories. [PDF]

, 2016
Neurodegeneration with brain iron accumulation (NBIA) is a group of disorders characterised by dystonia, parkinsonism and spasticity. Iron accumulates in the basal ganglia and may be accompanied by Lewy bodies, axonal swellings and hyperphosphorylated ...
Adibhatla, Aghajanian, Alazami, Alderson, Andrews, Balboa, Balsinde, Barbeito, Beck, Bosveld, Bras, Bras, Breus, Brissot, Broekemeier, Brunetti, Burn, Campanella, Chen, Cozzi, Crichton, Cui, Curtis, Dall'Armi, Daugherty, Davis, Deas, Dehay, Deng, Deschauer, Di Fonzo, Dick, Duran, Dusi, Eckhardt, Edvardson, Elbaz-Alon, Engel, Friedman, Fukunaga, Gadd, Gitler, Gonzalez-Cuyar, Green, Gregory, Gregory, Grünewald, Haack, Hailey, Hallgren, Hama, Hamasaki, Hartig, Hartig, Hayflick, Hayflick, Hill, Hogarth, Hong, Hortnagel, Houlden, Hönscher, Itoh, Iuso, Jana, Jenkins, Jeong, Jiang, Jin, Kaneko, Keller, Keogh, Kondo, Kono, Kotzbauer, Kruer, Kruer, Kruer, Kruer, Kurz, Kühlbrandt, Landouré, Larsson, Lei, Leonardi, Leoni, Levi, Li, Liou, Lu, Maday, Mahadevan, Malik, Mancuso, Manjithaya, Mariño, McNeill, Moreno, Morgan, Morita, Nemazanyy, Nousbeck, Oide, Ong, Paisan-Ruiz, Paisán-Ruiz, Park, Perry, Pivtoraiko, Poli, Polishchuk, Potter, Proikas-Cezanne, Ramirez, Ramonet, Rana, Riku, Ross, Ross, Rouault, Rouault, Roy, Saitsu, Scherz-Shouval, Schmidt, Schneider, Schneider, Seleznev, Shinzawa, Siudeja, Song, Strokin, Strokin, Tan, Tooze, Tsunemi, Usenovic, Vidal, Walia, Williams, Wu, Xu, Yadrick, Yang, Yoshida, Yoshida, Zhang, Zhou, Zorzi   +148 more
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Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins

Neurobiology of Disease, 2015
Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that ...
Manik C. Ghosh, De-Liang Zhang, Tracey A. Rouault   +2 more
doaj   +1 more source