Results 41 to 50 of about 90,175 (271)

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

An update on disordered iron metabolism and iron overload

Hematology, 2010
Iron overload is a major cause of morbidity and mortality in transfusion-dependent anemias. Greater understanding of the mechanisms of iron regulation and the role of toxic iron moieties and their predilection for certain organs has enhanced our ability to better target therapies in recent years, as illustrated by the Thalassemia syndromes.
openaire   +2 more sources

АЛЛЕЛИ 282Y И H63D ГЕНА HFE И ПРЕДРАСПОЛОЖЕННОСТЬ К СИНДРОМУ ХРОНИЧЕСКОЙ ПЕРЕГРУЗКИ ЖЕЛЕЗОМ И НАРУШЕНИЮ ПОРФИРИНОВОГО ОБМЕНА ПРИ НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИ

Архивъ внутренней медицины, 2012
Testing for carriers of mutations C282Y and H63D HFE gene in 57 patients with nonalcoholic fatty liver disease was completed. Abnormalities in the metabolism of porphyrins were detected in 39 (68.4%) patients, mutations C282Y and H63D were detected in 16
А. Б. Кривошеев, В. Н. Максимов, А. Д. Куимов, В. Ю. Ивасько, О. Н. Коваль, Д. Б. Даниленко, М. А. Кондратова, М. И. Воевода   +7 more
doaj   +1 more source

The relationship between ferrokinetic parameters and the state of cardiac remodeling in patients with coronary artery disease with concomitant iron deficiency

Patologìâ, 2023
The aim of the study: to assess the relationship between ferrokinetic parameters and the state of cardiac remodeling in patients with coronary artery disease (CAD) depending on the stage of iron deficiency (ID). Materials and methods.
M. O. Konovalova, N. S. Mykhailovska
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Direct Metal Deposition of Graphene–Ti28Nb35.4Zr Matrix Composites With Enhanced Mechanical, Corrosion, and Biocompatibility Properties for Bone Implants

Advanced Engineering Materials, EarlyView.
Graphene nanoplatelet (0.1 wt.%) reinforcement significantly enhances the performance of β Ti‐28Nb‐35.4Zr alloy. Grain refinement, reduced water contact angle, and improved surface characteristics promote osteoblast adhesion and complete surface coverage after 7 days.
Khurram Munir, Jixing Lin, Yuncang Li, Li Zhu, Paul F. A. Wright, Cuie Wen   +5 more
wiley   +1 more source

Hepcidin–Minireview [PDF]

Journal of Clinical and Diagnostic Research, 2013
Iron related disorders are encountered in daily clinical settings. Maintenance of stable extracellular iron concentrations requires the coordinate regulation of iron transport into plasma from dietary sources in the duodenum, from recycled senescent red
Subha Palaneeswari M., M. Ganesh, T. Karthikeyan, A.J. Manjula Devi, S.V. Mythili   +4 more
doaj   +1 more source

The role of ferritin in liver disease assessment

Фармакоэкономика, 2023
Background. Ferritin is an important integral and diagnostic marker of liver diseases. In 1/3 of patients with nonalcoholic fatty liver disease (NAFLD), manifestations of hyperferritinemia are revealed.
V. G. Radchenko, V. B. Grinevich, E. S. Ivanyuk, L. B. Lazebnik   +3 more
doaj   +1 more source

diabetes mellitus and iron metabolic disorders database

, 2020
The database contains data on patients with diabetes mellitus and disorders of carbohydrate metabolism - anthropometric data, data on the state of metabolic control parameters, data on the state of iron metabolism and lipid ...
Anastasia P. Zima, Nadezhda N. Musina, Tatiana V. Saprina, Tatiana S. Prokhorenko   +3 more
core   +1 more source