Results 171 to 180 of about 1,016,828 (293)

establishment secondary heart iron overload model in sprague rat [PDF]

Objective: Secondary iron overload is one of complication of Periodic blood transfusion in patients with hematologic diseases. Iron overload can result in iron deposition in heart tissue, which decreases cardia function, ultimately lead to death due to ...
ملک زاده, ودود, مهری پیرایواتلو, آرش, علی پناه مقدم, رضا, نعمتی, علی, منافی, فریده   +4 more
core  

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Iron overload disorders in adults: a comprehensive review of gonadal function, reproductive, and sexual health. [PDF]

Hum Reprod Update
Carlomagno F, Tenuta M, Sansone A, Rastrelli G, Sciarra F, Cangiano B, Isidori AM, Gianfrilli D, Krausz C.   +8 more
europepmc   +1 more source

Epigenetically Regulated NOX4/NRF2 Axis Mediates PM2.5‐Induced Ferroptosis and Inflammatory Response in Membranous Nephropathy

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aims to explore the involvement and mechanism of ferroptosis in particulate matter 2.5 (PM2.5)–induced membranous nephropathy (MN) progression. A cationic bovine serum albumin (cBSA)–induced mouse model of MN was established, followed by PM2.5 exposure.
Yanhong Gao, Yinfeng Guo, Shaoyan Xu, Min Zhang, Yanxia Rui, Shujun Pan, Changhua Zhou, Jianxiang Chen, Henglan Wu   +8 more
wiley   +1 more source

NCOA4-Mediated Ferritinophagy Contributes to Iron Overload-Driven Ferroptosis of Senescent Myoblasts in Mice. [PDF]

Cells
Huang Y, Qi Z, Chen C, Yu Z.
europepmc   +1 more source

Exposure–Recovery Approach for Hepatic Toxicity Analysis of Pyrethroid Lambda‐Cyhalothrin: Histopathological, Histochemical, and Biochemical Responses in Oreochromis niloticus

Journal of Applied Toxicology, EarlyView.
ABSTRACT Lambda‐cyhalothrin is a synthetic pyrethroid insecticide widely used in agriculture, but its potential to contaminate aquatic ecosystems and exert high toxicity on fish at low concentrations raises ecotoxicological concerns. While standard histopathological and biochemical assessments are common, the novel integration of pigment‐based ...
Carlos Eurico Fernandes, André Luiz do Nascimento Silva, Tiago Venancio da Silva, Karine Nathiele Nogueira Farias, Sabrina Fuzer Gonçalves, Brenda de Oliveira Martins, Maria Eduarda Corona Garcia, Lilian Franco‐Belussi   +7 more
wiley   +1 more source

Differential Effects of Cannabidiol and Cannabigerol on Cognition, Neuroinflammation, and Blood-Brain Barrier Integrity in a Rat Model of Iron Overload. [PDF]

Neurotox Res
Kowalski L, Colucci ACM, Dos Santos JB, Vuaden BW, Herlinger AL, Hallak JEC, Zuardi AW, Crippa JAS, de Lima MNM, Schröder N.   +9 more
europepmc   +1 more source

Genetic and Clinical Characteristics of Thalassemia Trait and Construction of LASSO‐Based Model for Its Differentiating From Iron Deficiency Anemia in Northern China

Journal of Clinical Laboratory Analysis, EarlyView.
This study revealed a β‐thalassemia‐trait‐dominated genetic spectrum in Northern‐Chinese patients with microcytic hypochromic anemia, with _αSEA/αα, HBB:c.316_197C>T and HBB:c.124_127delTTCT being the most prevalent α‐ and β‐globin genotypes. Using LASSO regression, we constructed a nomogram based on four routine complete‐blood‐count parameters (RBC ...
Wen‐jie Yu, Feng‐qi Zhang, Jia‐feng Niu, Rui Ma, Yin‐ting Ma, Guang‐ping Li, Yan Long   +6 more
wiley   +1 more source

A Rare Case of Possible Iron Overload and B12 Deficiency in Autoimmune Polyglandular Syndrome Type 3B. [PDF]

Cureus
Kyan K, Kumar R, Craig D.
europepmc   +1 more source

Evaluation of iron overload [PDF]

British Journal of Haematology, 2004
openaire   +3 more sources