Results 201 to 210 of about 122,333 (295)

Effects and mechanisms of iron overload on the proliferation and differentiation of preosteoblastic cells <i>via</i> a 3D microsphere culture system. [PDF]

Front Bioeng Biotechnol
Pan Y, Luo X, Zhao R, Zhang C, Luo X, Feng G, Xiao D.   +6 more
europepmc   +1 more source

Chronic Liver Disease: Assessing Inflammation and Fibrosis Using Three‐Dimensional MR Elastography With Same‐Day Biopsy in a Prospective Cohort

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Three‐dimensional (3D) MR elastography (MRE) derives viscoelastic parameters that may reflect inflammation, but their frequency dependence and the influence of steatosis on inflammation grading and fibrosis staging remain unclear. Purpose To investigate 3D multifrequency MRE for assessing hepatic inflammation, fibrosis stage across ...
Shan Cai, Christian Simonsson, Markus Karlsson, Wile Balkhed, Jens Tellman, Simone Ignatova, Patrik Nasr, Mattias Ekstedt, Stergios Kechagias, Wolf C. Bartholomä, Nils Dahlström, Peter Lundberg   +11 more
wiley   +1 more source

Iron overload disrupts lipid desaturation through SKN-1 signaling in <i>C. elegans</i>: implications for ferroptosis-based immunomodulatory biomaterials. [PDF]

Mater Today Bio
Dong Z, Liao Y, Shi H, Zhang J, Lin J, Liu Q, Zhang S, Fan X, Liu B, Wang Y, Zheng Y, Gao L.   +11 more
europepmc   +1 more source

Peri‐implant hypoxia as a potential barrier against ferroptotic mechanisms during peri‐implant diseases: A cross‐sectional study

Journal of Periodontology, EarlyView.
Abstract Background Hypoxia modulates inflammation and oxidative stress through hypoxia‐inducible factor‐1α (HIF‐1α). Ferroptosis, an iron‐dependent cell death process, is regulated by glutathione peroxidase‐4 (GPX4) and involves lipid peroxidation markers like malondialdehyde (MDA).
Büşra Yılmaz, Ali Gürkan, Beral Afacan, Harika Atmaca, Timur Köse, Gülnur Emingil   +5 more
wiley   +1 more source

Quantification of liver iron overload among pediatric patients with magnetic resonance imaging: current state of the art. [PDF]

Pol J Radiol
Hryniewicz GA, Świętoń D, Grzywińska M, Marunowski K, Piskunowicz M.   +4 more
europepmc   +1 more source

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source

The effect of HFE gene mutation and iron overload on sustained virological response in Egyptian chronic hepatitis C patients treated with daclatasvir and sofosbuvir. [PDF]

Korean J Intern Med
Kodsi EM, Ismail H, Issa R, Elshaarawy A, Sakr MA, Shehata EL, Issak ER.   +6 more
europepmc   +1 more source

Modulation of glucocorticoid receptor function under iron overload. [PDF]

Front Immunol
Zhu W, Vanderhaeghen T, Timmermans S, Vandewalle J, Eggermont M, Verhoog NJD, Libert C.   +6 more
europepmc   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, EarlyView.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

Comparison between dietary, parenteral, and genetic iron overload on bone health reveals secondary iron overload as a driver of cortical bone loss and fracture risk in mice. [PDF]

JBMR Plus
Steele-Perkins P, Yilmaz D, Walther Y, Wagner A, Paganoni R, Rauner M, Rauner M, Baschant U, Vujić Spasić M.   +8 more
europepmc   +1 more source