Results 211 to 220 of about 122,333 (295)

In Vivo Mapping of Catecholaminergic Loss and Iron Deposition in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background The pathophysiology of Huntington's disease (HD) remains obscure. Magnetic resonance imaging (MRI) can reveal in vivo molecular changes related to disease pathology. Objectives To investigate catecholaminergic neuronal integrity and subcortical brain iron accumulation in HD employing neuromelanin‐sensitive MRI, and quantitative ...
Edoardo R. de Natale, Heather Wilson, Efstratios Karavasilis, Athanasia Liozidou, Chrisoula Kartanou, Georgios Velonakis, Jens Kuhle, Ioannis Zalonis, Georgia Karadima, Leonidas Stefanis, Georgios Koutsis, Marios Politis   +11 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Single‐Breathhold 3D MR Elastography in the Liver, With Simultaneous R2* and PDFF Mapping

Magnetic Resonance in Medicine, EarlyView.
Purpose To develop a sequence for the rapid acquisition of MR elastography (MRE) parameters in 3D, with simultaneous measurement of proton‐density fat fraction (PDFF) and R2* for multiparametric assessment of liver disease. Methods The proposed sequence uses an interleaved motion‐encoding scheme to acquire 3D volumes of all motion encodings and wave ...
Donovan P Tripp, Anne‐Sophie van Schelt, Omar Darwish, Karl P Kunze, Shamsa Al Harthy, Nader S Metwalli, Ahmed M Gharib, Claudia Prieto, René M Botnar, Ralph Sinkus, Radhouene Neji   +10 more
wiley   +1 more source

β-thalassemia trait and iron overload: is it time to consider oral iron chelators? Comment on: "A case series of patients with β-thalassemia trait and iron overload: from multifactorial hepcidin suppression to treatment with mini-phlebotomies". [PDF]

Haematologica
Piperno A, Mariani R.
europepmc   +1 more source

Sanitary risk in the handling of home‐prepared enteral formulations: A cross‐sectional assessment of microbiological contamination and food safety

Nutrition in Clinical Practice, EarlyView.
Abstract Background Studies show increased use of home enteral nutrition (HEN) owing to its benefits. However, knowledge about the sanitary risks of handling home‐prepared formulas remains limited despite their high contamination rates. This study aimed to assess the sanitary risks in the handling of home‐prepared enteral formulations by analyzing ...
Marcelly Caroline Pires Fernandes, Marcia Regina Beux, Elaine Cristine de Souza Martins, Luciana Karbiak, Caroline Opolski Medeiros, Rayane Luizi da Costa, Lize Stangarlin‐Fiori   +6 more
wiley   +1 more source

Association Between Iron Overload and the Risk of Ocular Hypertension, Primary Open-Angle Glaucoma, and Normal-Tension Glaucoma. [PDF]

Transl Vis Sci Technol
Tsai CY, Tsai CY, Weng CH, Teng CJ, Pan SY, Ho WT, Huang SP, Lu YA, Lin CY, Lin JF, Lin CH, Lin HJ, Wang IJ, Chou CC.   +13 more
europepmc   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Correction: Mitochondrial iron overload-mediated inhibition of Nrf2-HO-1/GPX4 assisted ALI-induced nephrotoxicity. [PDF]

Front Pharmacol
Deng HF, Yue LX, Wang NN, Zhou YQ, Zhou W, Liu X, Ni YH, Huang CS, Qiu LZ, Liu H, Tan HL, Tang XL, Wang YG, Ma ZC, Gao Y.   +14 more
europepmc   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Iron overload is not the same everywhere: Particularities of iron-metabolism gene mutations in Brazil and a proposal for the investigation and management of iron overload in this population. [PDF]

Hematol Transfus Cell Ther
de Melo Campos P, Toreli AC, de Albuquerque DM, Costa FF.   +3 more
europepmc   +1 more source