Results 121 to 130 of about 23,803 (294)

The Effect of Neurotoxin MPTP and Neuroprotector Isatin on the Profile of Ubiquitinated Brain Mitochondrial Proteins

open access: yesCells, 2018
Mitochondria are a crucial target for the actions of neurotoxins, causing symptoms of Parkinson’s disease in various experimental animal models, and also neuroprotectors.
Olga Buneeva   +5 more
doaj   +1 more source

Cyclodextrin-based catalysts and molecular reactors [PDF]

open access: yes, 2015
We suggest two nonparametric approaches, based on kernel methods and orthogonal series to estimating regression functions in the presence of instrumental variables. For the first time in this class of problems, we derive optimal convergence rates, and
Easton, Christopher J.
core   +1 more source

Synthesis of 4-Amino-4,5-dihydro-1H-1,2,4-triazole-5-ones and their Isatin-3-imine Derivatives

open access: yesMolecules, 2005
Iminoester hydrochlorides 1 have been synthesized. These compounds werethen converted into ester ethoxycarbonyl hydrazones 2, from which in turn a new seriesof substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones, 3, was then prepared.Finally a set ...
Bahittin Kahveci
doaj   +1 more source

PET imaging of in vivo caspase-3/7 activity following myocardial ischemia-reperfusion injury with the radiolabeled isatin sulfonamide analogue [(18)F]WC-4-116 [PDF]

open access: yes, 2016
The utility of [(18)F]WC-4-116, a PET tracer for imaging caspase-3 activation, was evaluated in an animal model of myocardial apoptosis. [(18)F]WC-4-116 was injected into rats at 3 hours after a 30 min period of ischemia induced by temporary occlusion of
Chen, Delphine L   +8 more
core   +1 more source

Synthesis and reactivity of spiro-fused β-lactams [PDF]

open access: yes, 2011
A
D'hooghe, Matthias   +2 more
core   +2 more sources

Synthesis and evaluation of anticonvulsant activity of (Z)-4-(2-oxoindolin-3-ylideneamino)-N-phenylbenzamide derivatives in mice

open access: yesResearch in Pharmaceutical Sciences, 2018
Due to resistance of some epileptic patients to the current medications and the general incidence of severe side effects of these drugs, development and discovery of novel antiepileptic drugs is crucial.
Marzieh Rahmani Khajouei   +3 more
doaj   +1 more source

5-[(Z)-5-Chloro-2-oxoindolin-3-ylidene]-3-{(E)-[(4-hydroxyphenyl)imino]methyl}-2-thioxothiazolidin-4-one

open access: yesMolbank, 2019
N-aminorhodanine as well as isatin are highly solicited motifs known for their wide potential for biological activity. The objective of this work was to synthesize hybrid molecules as kinase inhibitors from these two motifs.
Abdelmounaim Safer   +2 more
doaj   +1 more source

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