Results 61 to 70 of about 16,503 (251)

Recent advances in isatin-derived hybrids: promising multifunctional agents for drug development [PDF]

Makedonsko Farmacevtski Bilten
Isatin-based hybrids have emerged as promising candidates in medicinal chemistry due to their broad biological activities and structural versatility. This review outlines recent developments (2020–2025) in the design of isatin hybrids targeting cancer ...
Aleksandar Dimkovski, Evgenija Mihajloska, Ana Poceva Panovska   +2 more
doaj   +1 more source

Facile synthesis of Schiff and Mannich bases of isatin derivatives [PDF]

, 2015
We report herein on the synthesis of some isatin Schiff’s bases (1–11), which were prepared from the reaction of isatin and some aromatic amines. These in turn were converted to the corresponding Mannich bases (12-23) by reaction with a number of ...
Al-azzawi, Nuhad K. E., Al-kadhimi, Ahmed A. H., Khalaf, Abedawn I.   +2 more
core  

Textile technology in Nepal in the 5th-7th centuries CE: the case of Samdzong [PDF]

, 2016
The first results of textile and dye analyses of cloth remains recovered in Samdzong, Upper Mustang, Nepal, are presented. The site consists of ten shaft tombs, dated between the 400-650 CE, cut into a high cliff face at an elevation of 4000 m asl.
Aldenderfer, M, Gleba, M, Vanden Berghe, I   +2 more
core   +2 more sources

Multistep Reactions Initiated by Amine‐Based Organometallic Methods

European Journal of Organic Chemistry, EarlyView.
The advent of C–H activation and other organometallic methodologies making use of transient directing groups or free amines themselves for the elaboration of amine substrates provides unique access to cascade‐type reactions that can generate significant molecular complexity in one pot. The pursuit of atom‐ and step‐economical pathways to access complex
Victoria D. Ho, Olutayo N. Farinde, Kendra K. Shrestha, Michael C. Young   +3 more
wiley   +1 more source

Cupreines and cupreidines: an established class of bifunctional cinchona organocatalysts [PDF]

, 2016
Cinchona alkaloids with a free 6'-OH functionality are being increasingly used within asymmetric organocatalysis. This fascinating class of bifunctional catalyst offers a genuine alternative to the more commonly used thiourea systems and because of the ...
Bryant, Laura A., Cobb, Alexander J. A., Fanelli, Rossana   +2 more
core   +2 more sources

Organocatalytic Enantioselective Synthesis of Oxindole‐4‐Aminopyrazolone Derivatives via Mannich Reaction of 3‐Substituted Oxindoles With Pyrazolinone Ketimines

Journal of Heterocyclic Chemistry, EarlyView.
Hydroquinine‐derived squaramide catalyzes the diastereo‐ and enantioselective Mannich reaction of pyrazolinone ketimines and 3‐aryl‐substituted oxindoles to access oxindole‐4‐aminopyrazolones with vicinal tetrasubstituted stereocenters. ABSTRACT The organocatalyzed Mannich reaction between pyrazolinone ketimines and 3‐aryl‐substituted oxindoles ...
María E. Molinero, Sandra Tejedor, Laura Martín, Alicia Maestro, José M. Andrés   +4 more
wiley   +1 more source

Pseudomonas aeruginosa Expresses a Functional Human Natriuretic Peptide Receptor Ortholog: Involvement in Biofilm Formation [PDF]

, 2016
This is the final version of the article. Available from the publisher via the DOI in this record.Considerable evidence exists that bacteria detect eukaryotic communication molecules and modify their virulence accordingly.
Bazire, A, Blier, AS, Boireau, W, Bouffartigues, E, Clamens, T, Diaz, S, Dufour, A, Feuilloley, MG, Harmer, NJ, Hoffmann, B, Hulen, C, Lesouhaitier, O, Mijouin, L, Rosay, T, Sergent, JA, Vieillard, J   +15 more
core   +1 more source

Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential

British Journal of Pharmacology, EarlyView.
Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley   +1 more source

Iodine-catalyzed Synthesis, Antibacterial, and Antioxidant Activity of Isatin Derivatives

Indonesian Journal of Chemistry
Isatin is a unique compound with many bioactivities such as antiviral, anti-HIV, antitumor, anti-inflammatory, anticonvulsant, and antifungal. In this study, isatin derivatives were synthesized with an iodine catalyst and tested for antibacterial and ...
Antonius Herry Cahyana, Agus Rimus Liandi, Yosua Ongkowidjawa   +2 more
doaj   +1 more source

Synthesis, Characterisation and Biological Activity Screening Of Schiff Base Ligands Containing Isatin and Their Metal Complexes [PDF]

, 2008
Six new Schiff bases formed from the condensation reaction of S-benzyldithiocarbazate (SBDTC) and S-methyldithiocarbazate (SMDTC) with selected diketones containing isatin derivatives namely isatin, 5-fluroisatin, 5-chloroisatin, 5-bromoisatin and ...
Abdul Manan, Mohd Abdul Fatah
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