Results 1 to 10 of about 956,618 (343)

Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies

International Journal of Molecular Sciences, 2021
Its increasing incidence has led stroke to be the second leading cause of death worldwide. Despite significant advances in recanalization strategies, patients are still at risk for ischemia/reperfusion injuries in this pathophysiology, in which ...
Anamaria Jurcău, A. Simion
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ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage

Signal Transduction and Targeted Therapy, 2022
Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease characterized by injury to cardiomyocytes leading to various forms of cell death.
Xiao-hui Ma, Jiang-Han-Zi Liu, Chun-yu Liu, Wan-Yang Sun, Wen-Jun Duan, Guan Wang, H. Kurihara, Rong-Rong He, Yi-Fang Li, Yang Chen, Hongcai Shang   +10 more
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Prevalence, Morphology, and Predictors of Intra-Stent Plaque Rupture in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study

Clinical and Applied Thrombosis/Hemostasis, 2022
Previous studies have shown that plaque rupture (PR) is the most important cause of acute coronary syndrome (ACS). However, the potential impact of intra-stent PR on stent failure manifesting as ACS and the optical coherence tomography (OCT) features of ...
Huai Yu MD, Jiannan Dai MD, Chao Fang MD, Senqing Jiang MD, Gary S. Mintz MD, Bo Yu MD   +5 more
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Predictors of Adverse Prognosis in Patients With Acute Coronary Syndrome Caused by Plaque Erosion With a Nonstent Strategy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background The EROSION (Effective Anti‐Thrombotic Therapy Without Stenting: Intravascular Optical Coherence Tomography‐Based Management in Plaque Erosion) study demonstrated that antithrombotic therapy without stenting was safe and feasible in selected ...
Yanwei Yin, Fangmeng Lei, Chao Fang, Senqing Jiang, Xueming Xu, Sibo Sun, Xueying Pei, Ruyi Jia, Caiying Tang, Cong Peng, Song Li, Lulu Li, Yini Wang, Huai Yu, Jiannan Dai, Bo Yu   +15 more
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Feasibility and Safety of Very-Low Contrast Combined Ringer's Solution in Optical Coherence Tomography Imaging

Frontiers in Cardiovascular Medicine, 2022
BackgroundOptical coherence tomography (OCT) is an important modality used in coronary intervention. However, OCT requires a high amount of contrast media, limiting its extensive application in clinical practice.
Tao Chen, Tao Chen, Huai Yu, Huai Yu, Lijia Ma, Lijia Ma, Chao Fang, Chao Fang, Haibo Jia, Haibo Jia, Huimin Liu, Huimin Liu, Maoen Xu, Maoen Xu, Donghui Zhang, Donghui Zhang, Guang Yang, Guang Yang, Shuangyin Zhang, Shuangyin Zhang, Jincheng Han, Jincheng Han, Guo Wei, Guo Wei, Yanchao Liu, Yanchao Liu, Jingbo Hou, Jingbo Hou, Bo Yu, Bo Yu   +29 more
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Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity

Circulation, 2021
Supplemental Digital Content is available in the text. Background: The ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) postulated that patients with stable coronary artery disease (CAD) and ...
H. Reynolds, L. Shaw, J. Min, C. Page, D. Berman, B. Chaitman, M. Picard, R. Kwong, Sean M. O'Brien, Zhen Huang, D. Mark, R. Nath, S. Dwivedi, P. Smanio, P. Stone, C. Held, M. Keltai, S. Bangalore, J. Newman, J. Spertus, G. Stone, D. Maron, J. Hochman   +22 more
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Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway

Cell Death and Disease, 2021
Inducing autophagy and inhibiting apoptosis may provide a therapeutic treatment for atherosclerosis (AS). For the treatment of progressive AS, arsenic trioxide (ATO) has been used to coat vascular stents.
Shaohong Fang, Xin Wan, Xiaoyi Zou, Song Sun, Xinran Hao, Chenchen Liang, Zhenming Zhang, Fangni Zhang, Bo Sun, Hulun Li, Bo Yu   +10 more
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Ischemia/reperfusion-activated ferroptosis in the early stage triggers excessive inflammation to aggregate lung injury in rats

Frontiers in Medicine, 2023
ObjectiveLung ischemia/reperfusion injury (LIRI) is a clinical syndrome of acute lung injury that occurs after lung transplantation or remote organ ischemia.
Xiujie Liu, Xiujie Liu, Binhui Pan, Xiaoting Wang, Xiaoting Wang, Junpeng Xu, Junpeng Xu, Xinyu Wang, Xinyu Wang, Zhengyang Song, Zhengyang Song, Eryao Zhang, Fangyan Wang, Fangyan Wang, Wantie Wang, Wantie Wang   +15 more
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Relationship of Microchannels and Plaque Erosion in Patients with ST-Segment Elevation Myocardial Infarction: An Optical Coherence Tomography Study

Cardiology Discovery, 2022
. Objective:. Microchannels are associated with the progression of atherosclerotic vulnerable plaques. However, in patients with culprit optical coherence tomography (OCT)-defined plaque erosion, the knowledge of microchannels and culprit lesion ...
Senqing Jiang, Junchen Guo, Yanwei Yin, Chao Fang, Jifei Wang, Yidan Wang, Fangmeng Lei, Sibo Sun, Xueying Pei, Ruyi Jia, Shaotao Zhang, Lulu Li, Yini Wang, Lei Xing, Huai Yu, Huimin Liu, Maoen Xu, Xuefeng Ren, Lijia Ma, Guo Wei, Jingbo Hou, Jiannan Dai, Bo Yu, Tianyu Xu, Xiaoxia Fu   +24 more
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Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury

Frontiers in Molecular Neuroscience, 2020
The cerebral ischemia injury can result in neuronal death and/or functional impairment, which leads to further damage and dysfunction after recovery of blood supply.
Liquan Wu, X. Xiong, Xiaomin Wu, Yingze Ye, Z. Jian, Z. Zhi, Lijuan Gu   +6 more
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