Results 1 to 10 of about 1,309,370 (384)

Inhibition of microRNA-183 expression resists human umbilical vascular endothelial cells injury by upregulating expression of IRS1

Drug Delivery, 2019
Our study aims to investigate the effect of microRNA-183 (miR-183) on human umbilical vascular endothelial cells (HUVECs) injury by targeting IRS1. HUVECs injury was induced by oxidized low-density lipoprotein (ox-LDL).
Yingying Zhang, Yefei Zhan, Dandan Liu, Bo Yu   +3 more
doaj   +1 more source

Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells

Frontiers in Genetics, 2020
Atherosclerosis is mediated by various factors and plays an important pathological foundation for cardiovascular and cerebrovascular diseases.
Jiangtian Tian, Jiangtian Tian, Yahong Fu, Yahong Fu, Qi Li, Qi Li, Ying Xu, Ying Xu, Xiangwen Xi, Xiangwen Xi, Yuqi Zheng, Yuqi Zheng, Li Yu, Li Yu, Zhuozhong Wang, Zhuozhong Wang, Bo Yu, Jinwei Tian   +17 more
doaj   +1 more source

Establishment of a Novel Mouse Model for Atherosclerotic Vulnerable Plaque

Frontiers in Cardiovascular Medicine, 2021
Background and Aims: Acute coronary syndrome (ACS) is a group of clinical syndromes characterized by rupture or erosion of atherosclerotic unstable plaques.
Xueyu Wang, Xueyu Wang, Yahong Fu, Yahong Fu, Zulong Xie, Muhua Cao, Muhua Cao, Wenbo Qu, Wenbo Qu, Xiangwen Xi, Xiangwen Xi, Shan Zhong, Shan Zhong, Minghui Piao, Minghui Piao, Xiang Peng, Xiang Peng, Ying Jia, Ying Jia, Lingbo Meng, Jinwei Tian   +20 more
doaj   +1 more source

Reversible Blockade of Complex I or Inhibition of PKCβ Reduces Activation and Mitochondria Translocation of p66\u3csup\u3eShc\u3c/sup\u3e to Preserve Cardiac Function after Ischemia [PDF]

, 2014
Aim Excess mitochondrial reactive oxygen species (mROS) play a vital role in cardiac ischemia reperfusion (IR) injury. P66Shc, a splice variant of the ShcA adaptor protein family, enhances mROS production by oxidizing reduced cytochrome c to yield H2O2 ...
Camara, Amadou K.S., Heisner, James S., Stowe, David F., Udoh, Kenechukwu B., Yang, Meiying   +4 more
core   +1 more source

Combined analysis of single-cell and bulk transcriptome sequencing data identifies critical glycolysis genes in idiopathic pulmonary arterial hypertension

Journal of Translational Medicine
Background Abnormal glycolytic metabolism plays a significant role in pulmonary vascular remodeling in idiopathic pulmonary arterial hypertension (IPAH), yet the specific mechanisms remain unclear.
Xuan Gao, Youli Fan, Guijia Wang, Jiangjiang Xu, Runwei Deng, Jiangwei Song, Binfeng Sun, Yongbing Wang, Zixuan Wu, Ruyi Jia, Jing Huang, Huiyu He, Lei Gao, Yihao Zhang, Na Sun, Bingxiang Wu   +15 more
doaj   +1 more source

Damage to Mitochondrial Complex I During Cardiac Ischemia Reperfusion Injury is Reduced Indirectly by Anti-anginal Drug Ranolazine [PDF]

, 2012
Ranolazine, an anti-anginal drug, is a late Na+ channel current blocker that is also believed to attenuate fatty acid oxidation and mitochondrial respiratory complex I activity, especially during ischemia.
Antholine, William E., Camara, Amadou K.S., Gadicherla, Ashish K., Stowe, David F., Yang, Meiying   +4 more
core   +2 more sources

Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2 [PDF]

, 2006
FGF-2, a potent multifunctional and neurotrophic growth factor, is widely expressed in the brain and upregulated in cerebral ischemia. Previous studies have shown that intraventricularly or systemically administered FGF-2 reduces the size of cerebral ...
Bohlen und Halbach, Oliver von, Dono, Rosanna, Kiprianova, Irina, Krause, Sonja, Schindowski, Katharina, Schwaninger, Markus, Unsicker, Klaus   +6 more
core  

Pharmacologic modulation of experimental postischemic hepatic function [PDF]

, 1989
The present study, evaluated and compared the effects of SRI 63-441, a potent platelet activating factor antagonist, superoxide dismutase (SOD), an oxygen free radical scavenger, and ibuprofen, a cyclooxygenase inhibitor on hepatic function after 90 ...
Makowka, L, Mazzaferro, V, Ontell, SJ, Ove, P, Starzl, TE, Trager, J   +5 more
core   +2 more sources

ATF3 promotes ferroptosis in sorafenib-induced cardiotoxicity by suppressing Slc7a11 expression

Frontiers in Pharmacology, 2022
Sorafenib is the unique recommended molecular-targeted drug for advanced hepatocellular carcinoma, but its clinical use is limited due to cardiotoxicity.
Yilan Li, Yilan Li, Jingru Yan, Jingru Yan, Qianqian Zhao, Qianqian Zhao, Yan Zhang, Yao Zhang, Yao Zhang   +8 more
doaj   +1 more source

ATP-sensitive potassium channel subcellular trafficking during ischemia, reperfusion, and preconditioning [PDF]

, 2016
Ischemic preconditioning is an endogenous cardioprotective mechanism in which short periods of ischemia and reperfusion provide protection when given before a subsequent ischemic event.
Ho, Joanne Cin-Yee
core   +1 more source