Results 71 to 80 of about 1,336,017 (348)

The role of glycogen synthase kinase 3 beta in brain injury induced by myocardial ischemia/reperfusion injury in a rat model of diabetes mellitus

Neural Regeneration Research, 2017
Myocardial ischemia/reperfusion injury can lead to severe brain injury. Glycogen synthase kinase 3 beta is known to be involved in myo-cardial ischemia/reperfusion injury and diabetes mellitus. However, the precise role of glycogen synthase kinase 3 beta
Bo Zhao, Wen-wei Gao, Ya-jing Liu, Meng Jiang, Lian Liu, Quan Yuan, Jia-bao Hou, Zhong-yuan Xia   +7 more
doaj   +1 more source

Cellular and molecular mechanisms of hepatic ischemia-reperfusion injury: The role of oxidative stress and therapeutic approaches

Redox Biology
Ischemia-reperfusion (IR) or reoxygenation injury is the paradoxical exacerbation of cellular impairment following restoration of blood flow after a period of ischemia during surgical procedures or other conditions.
Joseph George, Yong-Ke Lu, M. Tsuchishima, M. Tsutsumi   +3 more
semanticscholar   +1 more source

Evaluation of Pulmonary Reperfusion Injury in Rats Undergoing Mesenteric Ischemia and Reperfusion and Protective Effect of Postconditioning on this Process

Brazilian Journal of Cardiovascular Surgery, 2015
INTRODUCTION: Some publications have demonstrated the presence of lung reperfusion injury in mesenteric ischemia and reperfusion (I/R), but under to diverse methods.
Carlos Henrique Marques dos Santos, Ricardo Dutra Aydos, Ed Nogueira Neto, Luciana Nakao Odashiro Miiji, Pedro Carvalho Cassino, Isadora Ishaq Alves, Nádia Meneguesso Calheiros, Milena Garcia   +7 more
doaj   +1 more source

Taxifolin attenuates ischemia-reperfusion induced oxidative ovarian damage in rats

Asian Pacific Journal of Reproduction, 2021
Objective: To investigate preventive effects of taxifolin on ischemia-reperfusion induced oxidative ovarian damage in rats. Methods: A total of 18 female Wistar albino rats were randomly and equally divided into three groups: the sham group, the ovarian ...
Sevil Kiremitli, Tunay Kiremitli, Umit Nayki, Nesrin Yilmaz, Can Turkler, Kemal Dinc, Renad Mammadov, Gulce Naz Yazici, Mine Gulaboglu, Nihal Cetin   +9 more
doaj   +1 more source

Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy

International Journal on Biological Sciences
This study investigated the mechanism by which NR4A1 regulates mitochondrial fission factor (Mff)-related mitochondrial fission and FUN14 domain 1 (FUNDC1)-mediated mitophagy following cardiac ischemia-reperfusion injury(I/R).
Jun-Yan Wang, Hao-Wen Zhuang, Lian-Qun Jia, Xin-Yong He, Sicheng Zheng, Kangshou Ji, K. Xie, Tong Ying, Ying Zhang, Chun Li, Xing Chang   +10 more
semanticscholar   +1 more source

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

eLife
Hepatic ischemia/reperfusion injury (HIRI) is a common and inevitable factor leading to poor prognosis in various liver diseases, making the outcomes of current treatments in clinic unsatisfactory.
Fangyan Wang, Xiujie Liu, Furong Huang, Yan Zhou, Xinyu Wang, Zhengyang Song, Sisi Wang, Xiaoting Wang, Dibang Shi, Gaoyi Ruan, Xiawei Ji, Eryao Zhang, Zenglin Tan, Yuqing Ye, Chuang Wang, Jesse Zhu, Wantie Wang   +16 more
doaj   +1 more source

Involvement of Nitric Oxide in Microcirculatory Reactions after Ischemia-Reperfusion of the Rat Urinary Bladder [PDF]

, 2009
Background: Nitric oxide ( NO) plays a role in inflammation. Our aim was to investigate the role of NO in the microcirculatory changes after ischemia-reperfusion (I/R) of the bladder using intravital videomicroscopy (IVM).
Bajory, Z., Pajor László, Kiraly, I., Szabó Andrea, Messmer Konrad, Király István, Pajor, L., Bajory Zoltán, Messmer, K., Szabo, A.   +9 more
core   +1 more source

Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm [PDF]

, 2006
Background: Hypoxic cell death follows interruption of blood supply to tissues. Although successful restoration of blood flow is mandatory for salvage of ischemic tissues, reperfusion can paradoxically place tissues at risk of further injury.
MacAllister, R.J., Loukogeorgakis, S.P., Panagiotido, A.T., Yellon, D.M., Deanfield, J.E.   +4 more
core  

SR-A3 Promotes USP18-Mediated deISGylation of STING to Protect Against Myocardial Ischemia-Reperfusion Injury. [PDF]

Adv Sci (Weinh)
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Han Y, Miao G, Zhao Y, Du Z, Lu K, Xiao C, Xian A, Duanmu J, Zhou Z, Chen J, Zhang L, Zhai C, Xu Y, Li Z, Shen X, Shi S, Chen J, Mei S, Fang Y, Zheng L, Zhang L, Wang Y, Huang W, Dong E, Xian X.   +24 more
europepmc   +2 more sources

Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury [PDF]

, 2010
HDL, through sphingosine-1-phosphate (S1P), exerts direct cardioprotective effects on ischemic myocardium. It remains unclear whether other HDL-associated sphingophospholipids have similar effects.
Bodo Levkau, Levkau, Bodo, Herrgott, Ilka, Johanning, Kai, Echtermeyer, Frank, Chun, Jerold, Hildebrand, Reinhard, Ilka Herrgott, Gregor Theilmeier, Christine Herzog, Winterhalter, Michael, Frank Ulrich Müller, Schmitz, Martina, Müller, Frank Ulrich, Jan Mersmann, Michael Winterhalter, Reinhard Hildebrand, Martina Schmitz, Herzog, Christine, Frank Echtermeyer, Jerold Chun, Theilmeier, Gregor, Mersmann, Jan, Larmann, Jan, Jan Larmann, Kai Johanning   +25 more
core   +1 more source