Results 91 to 100 of about 184,947,225 (237)

Oxygen-dependent oxidation of proteins in the pathogenesis of spleen injury caused by acute blood loss, complicated by ischema-reperfusion of the limb and the efficiency of their correction by carbacetam

Journal of Education, Health and Sport, 2020
Activation of free radical processes is one of the key mechanisms of acute blood loss and ischemic-reperfusion syndrome. The spleen plays an important role in adaptive-compensatory processes during the blood loss.
I. V. Iavorska
doaj   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat [PDF]

, 2012
The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target.
Paulus, Patrick, Tacke Sabine, Johannes Holfeld, Karnowski Nora, Patrick Paulus, Holfeld, Johannes, Urbschat, Anja, Urbschat Anja, Zacharowski, Kai, Tacke, Sabine, Ockelmann, Pia, Nora Karnowski, Karnowski, Nora, Bertram Scheller, Scheller, Bertram, Pia Ockelmann, Ellinghaus, Peter, Paulus Patrick, Zacharowski Kai, Sabine Tacke, Ellinghaus Peter, Anja Urbschat, Kai Zacharowski, Peter Ellinghaus, Ockelmann Pia, Scheller Bertram, Holfeld Johannes   +26 more
core   +2 more sources

Biomimetic PB@PDA‐CA@Mem nanoplatform regulates oxidative stress and inflammatory microenvironment to enhance stroke recovery

VIEW, EarlyView.
PB@PDA‐CA@Mem enhances ischemic brain accumulation and enables acid‐responsive CA release. Through broad‐spectrum ROS/RNS scavenging, Nrf2/Keap1 activation, and NF‐κB/NLRP3 suppression, it alleviates oxidative stress and neuroinflammation, preserves neuronal architecture, reduces infarction, and improves functional recovery.
Lei Shi, Zhuonan Wang, Chenxi Zhou, Shuping Wang, Xuting Shen, Si Cheng, Yongli Yang, Nengrui Guo, Zhengrong Zhong, Lijun Bai   +9 more
wiley   +1 more source

Effects of penehyclidine hydrochloride in small intestinal damage caused by limb ischemia-reperfusion

World Journal of Gastroenterology, 2011
To investigate the protective effect of penehyclidine hydrochloride post-conditioning in the damage to the barrier function of the small intestinal mucosa caused by limb ischemia-reperfusion (LIR) injury.Male Wistar rats were randomly divided into three groups (36 rats each): the sham-operation group (group S), lower limb ischemia-reperfusion group ...
Yan, Zhang, Yu-Fang, Leng, Xing, Xue, Yue, Zhang, Tao, Wang, Yu-Qing, Kang   +5 more
openaire   +2 more sources

Acute lower limb ischemia - reperfusion injury

, 2022
Acute limb ischemia (ALI) occurs when there is a sudden reduction in limb perfusion due to an occlusion of peripheral arterial obstruction. The aim of the thesis is to give a brief overview on acute lower limb ischemia-reperfusion injury, involving ...
Do, Trung Anh
core  

Renal oxygenation, function and histopathology in an ovine model of heart failure undergoing cardiopulmonary bypass with 48 hours of recovery: a prospective, observational study*

Anaesthesia, EarlyView.
Summary Introduction Acute kidney injury is common after cardiac surgery requiring cardiopulmonary bypass, yet preventive strategies are limited. Progress has been hindered by a lack of clinically relevant experimental models incorporating pre‐existing heart disease.
Anton L. Trask‐Marino, Bruno Marino, Taku Furukawa, Lachlan F. Miles, Jai Raman, Andrew D. Cochrane, Peter R. McCall, Terase F. Lancefield, Roger G. Evans, Ian E. Birchall, Alemayehu H. Jufar, Ashenafi Betrie, Lars I.P. Snel, Munenori Kusunoki, Sally G. Hood, Linda Cornthwaite, Bruce Treagus, Connie Pei Chen Ow, Lindsea C. Booth, Clive N. May, Yugeesh R. Lankadeva   +20 more
wiley   +1 more source

The Effect of “Carvacrol” on Ischemia-Reperfusion Injury in the Skeletal Muscles of Rats [PDF]

Objective: Ischemia is characterized by an inadequate supply of nutrients and oxygen due to reduced blood circulation to specific tissues or organs.
Mustafa Kavutçu, KÜÇÜK, AYŞEGÜL, Kocak, Basak, KAVUTÇU, MUSTAFA, Mustafa Hakan Zor, Başak Koçak, Barış Mardin, Gürsel Levent Oktar, Mardin, Baris, Mardin, Barış, Ayşegül Küçük, ÖZER, ABDULLAH, ZOR, MUSTAFA HAKAN, OKTAR, GÜRSEL LEVENT, Mustafa Arslan, Şaban Cem Sezen, Abdullah Özer, Sezen, Saban Cem, ARSLAN, MUSTAFA   +18 more
core   +1 more source

Factors Affecting Surgical Outcomes Following Rotationplasty in Paediatric Sarcoma: A Literature Review

ANZ Journal of Surgery, EarlyView.
Rotationplasty is a durable limb‐salvage option for paediatric lower‐limb sarcoma. Across 58 studies and 1,217 patients, long‐term functional, psychosocial, and quality‐of‐life outcomes were favourable, often surpassing amputation and endoprosthetic reconstruction.
Rachel H. Ko, Stewart Morrison, Daniel J. Wilks   +2 more
wiley   +1 more source

Refinement of tourniquet-induced peripheral ischemia/reperfusion injury in rats: comparison of 2 h vs 24 h reperfusion. [PDF]

, 2014
Prolonged ischemia of skeletal muscle tissue, followed by reperfusion, leads to ischemia/reperfusion injury (IRI), which is a feared local and systemic inflammatory reaction. With respect to the 3Rs, we wanted to determine which parameters for assessment
Rieben, Robert, Dührkop-Sisewitsch, Claudia, Rieben R, Duehrkop C   +3 more
core   +1 more source