Results 101 to 110 of about 184,947,225 (237)

Post-conditioning through lower limb ischemia-reperfusion can alleviate lung ischemia-reperfusion injury.

International journal of clinical and experimental medicine, 2015
Operation on the infrarenal aorta could cause ischemic-reperfusion (IR) injury in local tissues and remote organs (e.g. the lung). We aim to explore the method of reducing lung ischemia-reperfusion damage after lower limb IR with post conditioning (LIPC).Bilateral lower limb ischemia was performed in Sprague-Dawley (SD) rats, and then animals were ...
Shi-Qiu, Song, Hui-Li, Gan, Jian-Qun, Zhang, Lei, Feng, Jian-Chao, Sun, Sheng-Xun, Wang   +5 more
openaire   +1 more source

An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response

, 2022
Ischemia-reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia-reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia-reperfusion mechanisms.
TANYELİ, AYHAN, Tuncer Nacar, ERASLAN, ERSEN, NACAR, TUNCER, ÖZBEK ŞEBİN, SAİME, Mustafa Can Güler, GÜZEL ERDOĞAN, DERYA, Ayhan Tanyeli, Fazile Nur Ekinci Akdemir, GÜLER, MUSTAFA CAN, Ersen Eraslan, Derya Güzel Erdoğan, EKİNCİ AKDEMİR, FAZİLE NUR, Saime Özbek Şebin   +13 more
core   +1 more source

Berbamine attenuates hind limb ischemia-reperfusion injury by eliminating lipid ROS and inhibiting p65 nuclear translocation

Frontiers in Pharmacology
This research aims to explore whether Berbamine (BBM) can mitigate tissue damage in mice resulting from hind limb muscle ischemia-reperfusion by scavenging lipid ROS and inhibiting p65 nuclear translocation. The hind limb ischemia-reperfusion (IR) injury
Lei Zheng, Biao Zhao, Run Ji, Zhenxi Zhang, Yutong Liu, Xiaoqi Zhao, Jing Cai, Tong Qiao   +7 more
doaj   +1 more source

Cannula Pairing Determines Distal Limb Perfusion During Peripheral Veno‐Arterial Extracorporeal Membrane Oxygenation: An Experimental Mock‐Loop Study

Artificial Organs, EarlyView.
Introducer sheaths are commonly used as distal perfusion cannulas during VA‐ECMO; efficacy is uncertain. A simplified hydraulic bench experiment evaluated cannula and connection configurations during clinically relevant blood flow using water and simulated blood media. Distal flow fraction decreased with larger arterial cannulas and was not restored by
Elliott Worku, Richard Lee, Ruaidhri Carey, Andre Kyme, Timothy Southwood   +4 more
wiley   +1 more source

Highly potent, brain‐penetrant EP2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin, Chenyao Jiang, Eun Bee Cho, M. Dennis Leo, Jiukuan Hao, Jiawang Liu, Ying Yu, Jianxiong Jiang   +7 more
wiley   +1 more source

ACE-inhibition prevents postischemic coronary leukocyte adhesion and leukocyte-dependent reperfusion injury [PDF]

, 1997
Objective: Polymorphonuclear leukocytes (PMN), retained in the microvascular bed, can contribute to postischemic myocardial reperfusion injury. Since a beneficial effect of ACE-inhibition on reperfusion injury has been reported, we investigated the ...
Weber, Christian, Messmer, Konrad, Habazettl, Helmut, Kupatt, Christian, Gerlach, Eckehart, Zahler, Stefan, Becker, Bernhard F., C Kupatt   +7 more
core   +1 more source

How effective are alprostadil and hydrocortisone on reperfusion injury in kidney after distant organ ischemia?

Journal of Research in Medical Sciences, 2013
Background: After reestablishment of blood flow to ischemic limb recirculation of free radicals may cause ischemia-reperfusion injury in many organs. This study designed to investigate effects of hydrocortisone and alprostadil distant injury to kidneys ...
Ali Ebrahimi, Fereshteh Salimi, Mansour Safaei, Hamid Melali, Amir Hosein Davarpanah Jazi, Mehdi Nematbakhsh, Nematbakhsh Mokhtari, Hamidreza Rasooli   +7 more
doaj  

Exploration of the interaction between remote ischemic preconditioning and anesthetic-induced preconditioning using sevoflurane in isolated perfused rabbit heart

The Ewha Medical Journal
Objectives: Remote ischemic preconditioning (rIPC) is a novel technique in which brief episodes of ischemia and reperfusion in one organ confer protection against prolonged ischemia in a distant organ. In contrast, anesthetic-induced preconditioning (APC)
Seung-Hee Yoo, Sooyoung Cho, Yoonsun Won, Jong Wha Lee   +3 more
doaj   +1 more source

Targeting a Novel AREG+ Dendritic Cell Alleviates Renal Fibrosis Induced by Ischemia–Reperfusion Injury

Cell Proliferation, EarlyView.
Renal IRI induces tubular EMT and fibrosis. CD11c+AREG+ DCs mediate the process via AREG‐EGFR axis, serving as promising therapeutic targets. ABSTRACT Renal ischemia–reperfusion injury (RIRI) is a major cause of acute tubular damage and a key driver of maladaptive repair and fibrosis.
Xin Luo, Longbin Xiong, Zhaohui Zhou, Lihao Zhang, Yulu Peng, Xiangpeng Zou, Yixin Huang, Yisong Lin, Xiaofeng Yang, Zhanji Zhan, Fangjian Zhou, Youhua Liu, Chunping Yu, Baokui Ye, Zhiling Zhang   +14 more
wiley   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source