Results 121 to 130 of about 184,947,225 (237)

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

HC‐A solution limb perfusion alleviates liver damage induced by limb ischemia–reperfusion injury in pigs

Animal Models and Experimental Medicine
AbstractBackgroundThe aim of the study was to explore a feasible method for alleviating limb ischemia–reperfusion injury (LI/RI) through the use of a high‐concentration citrate solution (HC‐A solution) for limb perfusion (LP).MethodsEighteen pigs were divided into three groups: the Sham group, LI/RI group, and HCA group.
Bowen Zhang, Weixiang Ni, Qinglong Cai, Huitao Ji, Junhao Du, Weixuan Hong, Junwei Fang, Lie Wang, Yafeng Qi, Chunhong Xiao   +9 more
openaire   +3 more sources

Sodium Hypochlorite-Modified Hemosorbents in the Treatment of Limb Ischemia-Reperfusion Syndrome: Experimental Study

Общая реаниматология, 2007
Objective: to enhance the efficiency of treatment for limb ischemia-reperfusion syndrome in an experiment, by using the modified hemosorbents that have oxidative properties.Materials and methods.
V. I. Sergiyenko, E. A. Petrosyan, V. I. Onopriyev, Kh. I. - Kh. M. Laipanov   +3 more
doaj   +1 more source

Physiological mechanisms underlying enhanced performance with blood flow restriction training: neuromuscular, vascular and metabolic adaptations

The Journal of Physiology, EarlyView.
Abstract figure legend We investigated how 6 weeks of dynamic knee‐extensor interval training with blood flow restriction (BFR‐leg) and without (CTRL‐leg) impacts performance and its mechanisms using non‐invasive methods. Specifically, we used gold‐standard methods to assess neuromuscular function, vascular function using Doppler ultrasound, and near ...
Colin Lavigne, Valentin Mons, Clément Lemineur, Oliver Meste, Georges Lefthériotis, Grégory M. Blain   +5 more
wiley   +1 more source

Prolonged low flow reduces reactive hyperemia and augments low flow mediated constriction in the brachial artery independent of the menstrual cycle [PDF]

, 2013
© 2013 Rakobowchuk et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Gibbins, Sarah E., Birch, KM, Sarah E Gibbins, Mark Rakobowchuk, Parsloe, Emily R., Emma Harris, Birch, Karen M., Parsloe, ER, Harris Emma, Gibbins, SE, Rakobowchuk Mark, Gibbins Sarah E., Harris, E, Rakobowchuk, Mark, Rakobowchuk, M, Parsloe Emily R., Birch Karen M., Karen M Birch, Harris, Emma, Emily R Parsloe   +19 more
core   +2 more sources

P2X3 receptor antagonism improves hindlimb blood flow during exercise in a conscious ovine model of hypertensive heart failure with preserved ejection fraction

The Journal of Physiology, EarlyView.
Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen, Siyi Chen, Joshua W.‐H. Chang, Audrys Pauza, Julia Shanks, Bindu George, Julian Paton, Rohit Ramchandra   +7 more
wiley   +1 more source

Lower extremity extracorporeal distal revascularization (LEEDR) as a novel approach to limb salvage following prolonged ischemia

Scientific Reports
Acute limb ischemia necessitates prompt revascularization to preserve viability and minimize systemic ischemia–reperfusion injury. Delays in care increase morbidity and mortality, underscoring the need for nonsurgical temporizing methods. Lower Extremity
Rebecca N. Treffalls, Grzegorz Jodlowski, Silvana Wilken, David P. Stonko, Patrick F. Walker, Jonathan J. Morrison   +5 more
doaj   +1 more source

Intranuclear localisation of KLF3‐AS1 under the balance of histone acetylation and methylation in BMSCs ameliorates cerebral ischaemia‒reperfusion injury by preserving microglial mitochondrial function and inhibiting inflammatory polarisation

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Epigenetic activation of KLF3‐AS1 in BMSCs, characterised by increased H3K27 acetylation and decreased H3K27 trimethylation at its promoter, enhances BMSC viability, proliferation and migration. Exosomal KLF3‐AS1 is delivered to microglia, which mechanistically promotes ETV4 nuclear translocation to activate SIRT3 transcription, preserving microglial ...
Qian Li, Xiaowei Xie, Jie Chen, Yu Cao, Dingzhou Zhou   +4 more
wiley   +1 more source

Beneficial Role of Natural Polyphenols Against Epilepsy: Greasing the Wheels of Pharmacotherapy Research for Epilepsy

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan, Rengasamy Balakrishnan, Manivasagam Muthukumaran Tamilarasan, Subasri Pandian   +3 more
wiley   +1 more source

Ursodeoxycholic Acid Confers Neuroprotection in Rats With Acute Cervical SCI and Attenuates NLRP3/Caspase‐1/GSDMD Pyroptotic Signaling

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Ursodeoxycholic Acid could inhibit activation of the NLRP3/Caspase‐1/GSDMD pyroptosis pathway and reduce the release of downstream inflammatory cytokines IL‐18 and IL‐1β in rats with acute C5 cervical SCI. This modulation is associated with attenuated secondary injury and improved functional outcomes.
Honghu Song, Xiaomin Hu, Dan Liu, Linjie Wang, Li Zhu, Wenchun Wang, Rongnan Hu, Jiayan Zhong, Jiancheng Liu, Rizhao Pang, Anren Zhang   +10 more
wiley   +1 more source