Results 11 to 20 of about 3,281 (176)

Ischemic Postconditioning Protects Aged Myocardium Against Ischemia/Reperfusion Injury by Regulating Mitochondrial Dynamics via piR-4913. [PDF]

Adv Sci (Weinh)
A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Zhao X, Li Y, Li N, Zhang J, Ma X, Yang F, Long R, Tian Y, Wang Y, Ma S, Zhang H, Jiang Y.   +11 more
europepmc   +2 more sources

TRF2 Recovers Ischemic Postconditioning Cardioprotection in Aged Myocardiocytes by Regulating CSNK2A2 Localization and FUNDC1 Dephosphorylation. [PDF]

Aging Cell
Myocardial expression of telomeric repeat‐binding factor 2 (TRF2) was reduced in aged male mice and further downregulated following ischemic postconditioning (I/Post). Mechanistically, TRF2 confers cardioprotection by interacting with casein kinase 2 alpha 2 polypeptide (CSNK2A2) to modulate FUN14 domain‐containing protein 1 (FUNDC1) dephosphorylation,
Zhang X, Ma J, Shu R, Li Y, Zheng Y, Yin Y.   +5 more
europepmc   +2 more sources

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA-34a-BDNF-SIX3 signaling axis. [PDF]

Animal Model Exp Med
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Zhao L, Zou C, Li J, Yang Y, Han Y, Ke T.   +5 more
europepmc   +2 more sources

Cerebral in situ ischemic postconditioning: From bench to bedside and beyond. [PDF]

Neuroprotection
This review explores the translational potential of in situ ischemic postconditioning in acute ischemic stroke. Preclinical and clinical evidence is summarized to highlight its promise as a neuroprotective strategy in the era of endovascular therapy.
Jiang X, Zhao W, Xu Y, Meng F, Wei M.
europepmc   +2 more sources

Ischemic Postconditioning in Pigs [PDF]

Circulation Research, 2009
Ischemic postconditioning (IPoC) reduces infarct size following ischemia/reperfusion. Whether or not phosphorylation of RISK (reperfusion injury salvage kinases) (AKT, ERK1/2, P70S6K, GSK3β) is causal for protection by IPoC is controversial.
Andreas, Skyschally, Patrick, van Caster, Kerstin, Boengler, Petra, Gres, Judith, Musiolik, Dustin, Schilawa, Rainer, Schulz, Gerd, Heusch   +7 more
openaire   +2 more sources

Comparison of the effects of direct and remote ischemic post and preconditioning in the kidney of young rats: histological and laboratory evaluation [PDF]

Acta Cirúrgica Brasileira
Purpose: To evaluate the effects of direct and remote ischemic preconditioning and postconditioning on kidney ischemia–reperfusion injury in young rats.
Arthur Henrique de Almeida Oliveira, Daniel Meirelles de Paula, Suellen Serafini, Uenis Tannuri, Ana Cristina Aoun Tannuri   +4 more
doaj   +2 more sources

Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats

Neural Regeneration Research, 2021
Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains.
Qiu-Shi Gao, Ya-Han Zhang, Hang Xue, Zi-Yi Wu, Chang Li, Ping Zhao   +5 more
doaj   +1 more source

Perconditioning combined with postconditioning on kidney ischemia and reperfusion [PDF]

Acta Cirúrgica Brasileira, 2017
Purpose: To evaluate if combination of perconditioning and postconditioning provides improved renal protection compared to perconditioning alone in a model of renal reperfusion injury.
Felipe Lobato da Silva Costa, Vitor Nagai Yamaki, Renan Kleber Costa Teixeira, Daniel Haber Feijó, André Lopes Valente, Luan Teles Ferreira de Carvalho, Edson Yuzur Yasojima, Marcus Vinicius Henriques Brito   +7 more
doaj   +2 more sources

Anti-Inflammatory and Antipruritic Effects of Remote Ischaemic Postconditioning in a Mouse Model of Experimental Allergic Contact Dermatitis

Medicina, 2023
Background and Objectives: Allergic contact dermatitis is a common type IV hypersensitivity reaction characterised by redness, itching, oedema and thickening of the skin. It occurs in about 7% of the population and its incidence is increasing.
Ozgur Gunduz, Melike Sapmaz-Metin, Ruhan Deniz Topuz, Oktay Kaya, Cetin Hakan Karadag, Ahmet Ulugol   +5 more
doaj   +1 more source

rt‐PA with remote ischemic postconditioning for acute ischemic stroke [PDF]

Annals of Clinical and Translational Neurology, 2019
AbstractObjectiveTo investigate the feasibility and safety of remote ischemic postconditioning (RIPC) in acute ischemic stroke patients after intravenous recombinant tissue plasminogen activator (rt‐PA) thrombolysis (IVT).MethodsWe performed a pilot randomized trial involving acute ischemic stroke patients with IVT.
Che, Ruiwen, Zhao, Wenbo, Ma, Qingfeng, Jiang, Fang, Wu, Longfei, Yu, Zhipeng, Zhang, Qian, Dong, Kai, Song, Haiqing, Huang, Xiaoqin, Ji, Xunming   +10 more
openaire   +2 more sources