Results 41 to 50 of about 3,281 (176)

Morphine and remifentanil-induced cardioprotection: its experimental and clinical outcomes [PDF]

Korean Journal of Anesthesiology, 2011
During the past few decades, a large number of animal studies demonstrated that commonly used opioids could provide cardioprotection against ischemia-reperfusion (I/R) injury.
Jin Mo Kim, Young Ho Jang, Jun Kim
doaj   +1 more source

Targeting STAT3 to Modulate the Effectiveness of Cardioprotective Conditioning Strategies Against Myocardial Ischemia–Reperfusion Injury in Subjects With Diabetic Cardiomyopathy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 20, October 2026.
ABSTRACT Myocardial ischemia–reperfusion injury (MIRI) is a major cause of cardiovascular morbidity and mortality. Reperfusion, although essential for myocardial restoration, can paradoxically exacerbate injury through oxidative stress, calcium overload, mitochondrial permeability transition pore opening and inflammatory infiltration. The vulnerability
Chunyan Wang, Wangli Tian, Saman Saedi, Hengzhen Cui, Danyong Liu, Qinjun Chu, Dongwei Yang, Zhengyuan Xia   +7 more
wiley   +1 more source

Impact of Ischemic Postconditioning on Outcome in Patients with Anterior ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention [PDF]

Zagazig University Medical Journal
Background: Reperfusion therapy remains important for managing of ST-segment elevation myocardial infarction (STEMI), it carries the risk of additional myocardial injury. Ischemic postconditioning (iPOST) has been proposed to minimize that injury.
Marwa Gad, Ahmed Ahmed, Abdelkader Elbakry, Mohamed Allam   +3 more
doaj   +1 more source

Ischemic postconditioning fails to protect against neonatal cerebral stroke. [PDF]

PLoS ONE, 2012
The lack of efficient neuroprotective strategies for neonatal stroke could be ascribed to pathogenic ischemic processes differentiating adults and neonates. We explored this hypothesis using a rat model of neonatal ischemia induced by permanent occlusion
Pierre-Louis Leger, Philippe Bonnin, Thao Nguyen, Sylvain Renolleau, Olivier Baud, Christiane Charriaut-Marlangue   +5 more
doaj   +1 more source

Actin-Cytoskeleton Drives Caveolae Signaling to Mitochondria during Postconditioning

Cells, 2023
Caveolae-associated signaling toward mitochondria contributes to the cardioprotective mechanisms against ischemia-reperfusion (I/R) injury induced by ischemic postconditioning.
Francisco Correa, Cristina Enríquez-Cortina, Alejandro Silva-Palacios, Nadia Román-Anguiano, Aurora Gil-Hernández, Marcos Ostolga-Chavarría, Elizabeth Soria-Castro, Sharik Hernández-Rizo, Paola de los Heros, María Chávez-Canales, Cecilia Zazueta   +10 more
doaj   +1 more source

S14G‐humanin attenuates renal ischaemia–reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats

Experimental Physiology, Volume 111, Issue 10, Page 4915-4927, 1 October 2026.
Abstract Renal ischaemia–reperfusion (I/R) injury leads to acute tubular necrosis and renal failure, triggering pathological mechanisms including inflammation, reactive oxygen species generation, apoptosis and mitochondrial dysfunction. The mitochondrial peptide humanin (HN), known to possess anti‐apoptotic and anti‐inflammatory properties, has been ...
Leyla Abueid, Ahmet Faruk Torun, Ezgi Golal, Nuray Acar, Filiz Basrali   +4 more
wiley   +1 more source

Effect of Ischemic Postconditioning in Correction of Tetralogy of Fallot

International Heart Journal, 2011
Inappropriate myocardial protection is considered one of the main causes of mortality and morbidity in the correction of tetralogy of Fallot (TOF). Results of previous reports about the effects of ischemic postconditioning on myocardial protection in animals and humans are very encouraging.
Ji, Qiang, Mei, Yunqing, Wang, Xisheng, Feng, Jing, Wusha, Dewei, Cai, Jianzhi, Zhou, Yongxin   +6 more
openaire   +3 more sources

Neurocardiology: Brain–Heart Interactions in the Heart

MedComm, Volume 7, Issue 9, September 2026.
The heart and brain maintain systemic homeostasis through bidirectional communication involving neural, biochemical, and mechanical pathways. Dysregulation of these pathways contributes to a spectrum of conditions involving heart–brain interactions, including Takotsubo syndrome, the epileptic heart, stroke–heart syndrome, heart failure, cardiac ...
Wentao Wang, Hao Jia, Han Han, Jiangping Song   +3 more
wiley   +1 more source

Is ischemic postconditioning in STEMI worth pursuing? [PDF]

Journal of Thoracic Disease, 2017
We have, with interest, read the editorial on our study DANAMI-3–iPOST (1) and do agree on most of the aspects touched upon. We do, however, want to add to the editorial by raising a few points.
Engstrøm, Thomas, Lønborg, Jacob
openaire   +3 more sources

Protective Effect of Isoflurane on Hypoxia/Reoxygenation‐Induced Myocardial Injury via miR‐548a‐5p Regulation of PTEN

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
H/R injury downregulates miR‑548a‑5p and upregulates its direct target PTEN in H9c2 cardiomyocytes, triggering reduced cell viability, elevated apoptosis, oxidative stress and myocardial injury marker release. 1.0% isoflurane (ISO) pretreatment reverses these pathological alterations by elevating miR‑548a‑5p and repressing PTEN.
Ji Yao, Jianyong Zheng, Wei Wei
wiley   +1 more source