Results 51 to 60 of about 3,281 (176)

Sevoflurane Alleviates Myocardial Ischemia‐Reperfusion Injury via the HMGB1/ACSL4 Pathway to Suppress Ferroptosis

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Sevoflurane (sevo) alleviates ferroptosis in cardiomyocytes and ameliorates MI/RI symptoms by inhibiting HMGB1 expression, reducing ACSL4 stability, and negatively regulating the HMGB1/ACSL4 signaling pathway. ABSTRACT Sevoflurane (sevo) exhibits cardioprotective effects against myocardial ischemia/reperfusion injury (MIRI); however, its precise ...
Yuliu Mei, Yunfei Cao, Cheng Sheng, Ge Sun, Manhua Zhu   +4 more
wiley   +1 more source

Protective Effect of Delayed Ischemic Postconditioning on Embolic Stroke Complications in Female Rat [PDF]

Journal of Kerman University of Medical Sciences, 2014
Background & Aims: Ischemic postconditioning, conducted by a series of brief occlusion and release of the bilateral common carotid arteries, has neuroprotective properties in permanent or transient models of middle cerebral artery (MCA) occlusion but its
M Mobini, H Rezazadeh, A Shamsizadeh, V Ehsani, E Hakimizadeh, S Amir-Esmaili, M Allahtavakoli   +6 more
doaj  

Postconditioning ameliorates lipid peroxidation in liver ischemia-reperfusion injury in rats Pós-condicionamento melhora a peroxidação lipídica na lesão de isquemia-reperfusão hepática em ratos

Acta Cirúrgica Brasileira, 2009
PURPOSE: Liver ischemia-reperfusion injury is a phenomenon presents in events like liver resections and transplantation. The restoration of blood flow may leads to local and systemic injury.
Antonio Roberto Franchi Teixeira, Nilza T. Molan, Márcia Saldanha Kubrusly, Marta Bellodi-Privato, Ana Maria Coelho, Kátia R. Leite, Marcel Autran Cesar Machado, Telésforo Bacchella, Marcel Cerqueira César Machado   +8 more
doaj   +1 more source

MITF Regulates CFTR Expression to Participate in Myocardial Ischemia–Reperfusion Injury

The Journal of Gene Medicine, Volume 28, Issue 8, August 2026.
MITF regulates CFTR expression in MIRI, and disruption of the MITF‐CFTR axis is associated with aggravated injury in cellular and animal models. Restoring CFTR partially mitigates MITF deficiency‐related damage. These findings support the involvement of MITF‐CFTR regulation in MIRI and provide a basis for further mechanistic investigation.
Baoxin Tang, Chenying Zhu, Heqing Wang, Mingkui Gao, Tieyan Li   +4 more
wiley   +1 more source

Effect of remote ischemic conditioning on atrial fibrillation and outcome after coronary artery bypass grafting (RICO-trial)

BMC Anesthesiology, 2011
Background Pre- and postconditioning describe mechanisms whereby short ischemic periods protect an organ against a longer period of ischemia. Interestingly, short ischemic periods of a limb, in itself harmless, may increase the ischemia tolerance of ...
Wouters Patrick, Momeni Mona, Driessen Antoine HG, de Mol Bas AJM, de Groot Joris R, Dijkgraaf Marcel GW, Weber Nina C, Schlack Wolfgang S, Tolenaar Noortje, de Bruin Anton, Heijnen Bram GADH, van Dongen Eric HPA, De Hert Stefan G, Hollmann Markus W, Brevoord Daniel, Bouchez Stefaan, Hofland Jan, Lüthen Christan, Meijer-Treschan Tanja A, Pannen Benedikt H, Preckel Benedikt   +20 more
doaj   +1 more source

Remote Ischemic Postconditioning During Percutaneous Coronary Interventions [PDF]

Circulation: Cardiovascular Interventions, 2014
Background— Remote ischemic preconditioning may result in reduction in infarct size during percutaneous coronary intervention (PCI). It is unclear whether remote ischemic postconditioning (RIPost) will reduce the incidence of myocardial injury after PCI, and whether ischemic conditioning of a larger remote organ (thigh versus ...
Lavi, Shahar, D'Alfonso, Sabrina, Diamantouros, Pantelis, Camuglia, Anthony, Garg, Pallav, Teefy, Patrick, Jablonsky, George, Sridhar, Kumar, Lavi, Ronit   +8 more
openaire   +4 more sources

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Hypercholesterolemic myocardium is vulnerable to ischemia-reperfusion injury and refractory to sevoflurane-induced protection. [PDF]

PLoS ONE, 2013
Recent studies have demonstrated that volatile anesthetic postconditioning confers myocardial protection against ischemia-reperfusion (IR) injury through activation of the reperfusion injury salvage kinase (RISK) pathway.
Yong Xu, Lei-Lei Ma, Chen Zhou, Fei-Jiang Zhang, Fei-Juan Kong, Wen-Na Wang, Ling-Bo Qian, Can-Can Wang, Xian-Bao Liu, Min Yan, Jian-An Wang   +10 more
doaj   +1 more source

Evaluation of the Effects of Atorvastatin and Ischemic Postconditioning Preventing on the Ischemia and Reperfusion Injury: Experimental Study in Rats

Brazilian Journal of Cardiovascular Surgery
Introduction: Reperfusion injury leads to systemic morphological and functional pathological alterations. Some techniques are already estabilished to attenuate the damage induced by reperfusion. Ischemic preconditioning is one of the standard procedures.
Henrique Budib Dorsa Pontes, José Carlos Dorsa Vieira Pontes, Euler de Azevedo Neto, Giovanna Serra da Cruz Vendas, João Victor Cunha Miranda, Letícia do Espírito Santos Dias, João Victor Durães Gomes Oliva, Murilo Henrique Martins de Almeida, Ian de Oliveira Chaves, Tricia Luna Sampaio, Carlos Henrique Marques dos Santos, Doroty Mesquita Dourado   +11 more
doaj   +1 more source

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

The Journal of Physiology, Volume 604, Issue 16, Page 6659-6674, 15 August 2026.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich, Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Ryan Gemilere, Samira M. Azarin, Julia C. Liu   +5 more
wiley   +1 more source