Results 71 to 80 of about 8,004 (220)

Hypercholesterolemic myocardium is vulnerable to ischemia-reperfusion injury and refractory to sevoflurane-induced protection. [PDF]

PLoS ONE, 2013
Recent studies have demonstrated that volatile anesthetic postconditioning confers myocardial protection against ischemia-reperfusion (IR) injury through activation of the reperfusion injury salvage kinase (RISK) pathway.
Yong Xu, Lei-Lei Ma, Chen Zhou, Fei-Jiang Zhang, Fei-Juan Kong, Wen-Na Wang, Ling-Bo Qian, Can-Can Wang, Xian-Bao Liu, Min Yan, Jian-An Wang   +10 more
doaj   +1 more source

Myocardial ischaemia reperfusion injury: the challenge of translating ischaemic and anaesthetic protection from animal models to humans [PDF]

, 2016
Myocardial ischaemia reperfusion injury is the leading cause of death in patients with cardiovascular disease. Interventions such as ischaemic pre and postconditioning protect against myocardial ischaemia reperfusion injury. Certain anaesthesia drugs and
Irwin, MG, Li, H, Xia, Z
core   +1 more source

Breaking the Barrier: Unraveling the No‐Reflow Phenomenon in Cardiovascular Medicine

Catheterization and Cardiovascular Interventions, Volume 106, Issue 3, Page 1937-1945, September 1, 2025.
ABSTRACT The no‐reflow phenomenon is a stubborn and often devastating complication in cardiovascular medicine, where blood flow is restored to an artery, yet the microvasculature remains unresponsive. First identified in 1967, this phenomenon has haunted clinicians and researchers alike, particularly in the context of acute myocardial infarction (AMI).
Stephanie Howes, Osamah Altaee, Ariana Ramirez, Loreto Calaquian, Anum Asif, Collin Stone, Muhammad Hammadah, Debanshu Roy, Bryan Ramsey, Robert Chilton   +9 more
wiley   +1 more source

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function

European Journal of Heart Failure, Volume 27, Issue 9, Page 1720-1736, September 2025.
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard, Mahmoud Abdellatif, Ioanna Andreadou, Christian Bär, Luc Bertrand, Bianca J.J.M. Brundel, Gemma Chiva‐Blanch, Sean M. Davidson, Dana Dawson, Fabio Di Lisa, Paul Evans, Zoltan Giricz, Derek J. Hausenloy, Petra Kleinbongard, Frank Lezoualc'h, Elisa Liehn, Christoph Maack, Ange Maguy, Elizabeth Murphy, Cinzia Perrino, Maurizio Pesce, Peter P. Rainer, Katrin Streckfuss‐Bömeke, Matthias Thielmann, Rong Tian, Carlo G. Tocchetti, Jolanda Van Der Velden, Sophie Van Linthout, Serena Zacchigna, Thomas Krieg   +29 more
wiley   +1 more source

Ischemic postconditioning alters the gene expression pattern of the ischemic heart

Experimental Biology and Medicine, 2014
To profile changes in gene expression in response to ischemic postconditioning, isolated rat hearts were subjected to 30 min of regional ischemia followed by 120 min of reperfusion with or without postconditioning. At the end of reperfusion, cardiac RNA was assayed by DNA microarrays (31,000 format), verified by quantitative real-time polymerase chain
Csonka, Csaba, Szűcs, Gergő, Varga-Orvos, Zoltán, Bencsik, Péter, Csont, Tamás Bálint, Zvara, Ágnes, Puskás, László, Ferdinandy, Péter   +7 more
openaire   +3 more sources

Prospects for Creation of Cardioprotective Drugs Based on Cannabinoid Receptor Agonists [PDF]

, 2015
Cannabinoids can mimic the infarct-reducing effect of early ischemic preconditioning, delayed ischemic preconditioning, and ischemic postconditioning against myocardial ischemia/reperfusion.
De Petrocellis, Luciano, Downey, James, Khaliulin, Igor, Krylatov, Andrey, Maslov, Leonid, Mechoulam, Raphael, Naryzhnaya, Natalia, Zhang, Yi   +7 more
core   +2 more sources

Seizure Activity and Hypoxia Differentially Regulate Endogenous Neurotrophic Activin A and Neuroglobin Expression in the Immature Mouse Brain

International Journal of Developmental Neuroscience, Volume 85, Issue 5, August 2025.
We investigated the regulatory effects of seizure‐induced excitotoxicity and acute hypoxia on the cytoprotective activin A and Ngb systems in the developing mouse brain. Our results demonstrate the differential regulation of Ngb and activin A as a function of time and type of injury and suggest their potential role as biomarkers of excitotoxic and ...
Clara Becker, Susan Jung, Regina Trollmann   +2 more
wiley   +1 more source

Evaluation of the Effects of Atorvastatin and Ischemic Postconditioning Preventing on the Ischemia and Reperfusion Injury: Experimental Study in Rats

Brazilian Journal of Cardiovascular Surgery
Introduction: Reperfusion injury leads to systemic morphological and functional pathological alterations. Some techniques are already estabilished to attenuate the damage induced by reperfusion. Ischemic preconditioning is one of the standard procedures.
Henrique Budib Dorsa Pontes, José Carlos Dorsa Vieira Pontes, Euler de Azevedo Neto, Giovanna Serra da Cruz Vendas, João Victor Cunha Miranda, Letícia do Espírito Santos Dias, João Victor Durães Gomes Oliva, Murilo Henrique Martins de Almeida, Ian de Oliveira Chaves, Tricia Luna Sampaio, Carlos Henrique Marques dos Santos, Doroty Mesquita Dourado   +11 more
doaj   +1 more source

Limb remote ischemic postconditioning protects integrity of the blood-brain barrier after stroke

Neural Regeneration Research, 2018
Integrity of the blood-brain barrier structure is essential for maintaining the internal environment of the brain. Development of cerebral infarction and brain edema is strongly associated with blood-brain barrier leakage.
Juan Li, Xiao-Song Hu, Fang-Fang Zhou, Shuai Li, You-Sheng Lin, Wen-Qian Qi, Cun-Fang Qi, Xiao Zhang   +7 more
doaj   +1 more source

Remifentanil post-conditioning attenuates cardiac ischemia-reperfusion injury via κ or δ opioid receptor activation [PDF]

, 2010
Background: Ischemic pre- or post-conditioning of the heart has been shown to involve opioid receptors. Remifentanil, an ultra-short-acting selective μ opioid receptor agonist in clinical use, pre-conditions the rat heart against ischemia-reperfusion ...
Irwin, MG, Jiang, LL, Li, R, Wong, GTC
core   +1 more source