Results 81 to 90 of about 8,004 (220)

Mitochondrial Quality Control in Health and Disease

MedComm, Volume 6, Issue 8, August 2025.
Mitochondrial quality control (MQC) maintains cellular homeostasis by coordinating various processes such as fission, fusion, mitophagy, and mitochondria‐regulated cell death. Dysregulation of these mechanisms plays a key role in the development of many human diseases.
Lin Ye, Xinzhi Fu, Qi Li
wiley   +1 more source

Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options

Frontiers in Neurology, 2018
Novel and innovative approaches are essential in developing new treatments and improving clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a series of mechanical interruptions in blood flow of a distal organ ...
Gangling Chen, Gangling Chen, Mrugesh Thakkar, Christopher Robinson, Christopher Robinson, Sylvain Doré, Sylvain Doré, Sylvain Doré, Sylvain Doré, Sylvain Doré, Sylvain Doré, Sylvain Doré   +11 more
doaj   +1 more source

Is ischemic postconditioning in STEMI worth pursuing? [PDF]

Journal of Thoracic Disease, 2017
We have, with interest, read the editorial on our study DANAMI-3–iPOST (1) and do agree on most of the aspects touched upon. We do, however, want to add to the editorial by raising a few points.
Engstrøm, Thomas, Lønborg, Jacob
openaire   +3 more sources

Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage [PDF]

, 2014
Background: Intracerebral hemorrhage is a subtype of stroke that has a poor prognosis without an adequate therapy. Recently, the use of anesthetics such as isoflurane has been shown to be protective after cerebral ischemia.
Esposito, Elga, Lo, Eng H, Mandeville, Emiri T   +2 more
core   +1 more source

Kapβ2 Reverses Sevoflurane‐Induced Hydrogel Phase Transition of hnRNPA2/B1‐SG in Hypoxic Primary Rat Hippocampal Neurons

CNS Neuroscience &Therapeutics, Volume 31, Issue 8, August 2025.
Sevoflurane exacerbates hippocampal neuronal dysfunction under hypoxic conditions by inducing the cytoplasmic mislocalization of hnRNPA2/B1, which drives abnormal liquid–liquid phase separation (LLPS) and subsequent irreversible hydrogel transition of hnRNPA2/B1‐containing stress granules (SGs).
Miao Zhang, Xinyi Wang, Feiyu Jia, Chenyi Yang, Zixuan Wang, Huihui Liao, Lin Zhang, Xi Xin, Haiyun Wang   +8 more
wiley   +1 more source

Sevoflurane postconditioning improves spatial learning and memory ability involving mitochondrial permeability transition pore in hemorrhagic shock and resuscitation rats

Brain and Behavior, 2020
Background Hemorrhagic shock induces the cognitive deficiency. Sevoflurane postconditioning has been documented to provide neuroprotection against ischemic–reperfusion injury by suppressing apoptosis.
Li Zhang, Li Huang, Jingxian Wang, Muchun Zhang, Ye Zhang, Xianwen Hu   +5 more
doaj   +1 more source

New insights into disease‐modifying factors and clinical translation for central nervous system diseases

Neuroprotection, Volume 4, Issue 1, Page 1-3, March 2026.
Shen Li, Xunming Ji, Piotr Walczak, Johannes Boltze   +3 more
wiley   +1 more source

Mitochondrial transplantation combined with mitoquinone and melatonin: A survival strategy against myocardial reperfusion injury in aged rats

Experimental Physiology, Volume 110, Issue 6, Page 844-856, 1 June 2025.
Abstract Myocardial ischaemia–reperfusion (IR) injury poses a severe threat to cardiac health, particularly in the ageing population, where susceptibility to such damage is significantly heightened owing to age‐related declines in mitochondrial function, thus highlighting mitochondria as crucial targets for innovative therapies.
Behnaz Mokhtari, Mitra Delkhah, Reza Badalzadeh, Samad Ghaffari   +3 more
wiley   +1 more source

Ischemic Postconditioning Protects Neuronal Death Caused by Cerebral Ischemia and Reperfusion via Attenuating Protein Aggregation

International Journal of Medical Sciences, 2012
Objective: To investigate the effect of ischemic postconditioning on protein aggregation caused by transient ischemia and reperfusion and to clarify its underlying mechanism.Methods: Two-vessel-occluded transient global ischemia rat model was used.
Jianmin Liang, Jihang Yao, Guangming Wang, Ying Wang, Boyu Wang, Pengfei Ge
doaj  

Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway [PDF]

, 2017
OBJECTIVE: We tested whether ischemic postconditioning (IPostC) is protective in remodeled myocardium. METHODS: Post-myocardial infarct (MI)-remodeled hearts after permanent coronary artery ligation and one kidney one clip (1K1C) hypertensive hearts of ...
Feng, J., Fischer, G., Lucchinetti, E., Pedrazzini, T., Schaub, M C., Xu, L., Zaugg, M., Zhu, M.   +7 more
core