Results 61 to 70 of about 8,004 (220)

Extending injury- and disease-resistant CNS phenotypes by repetitive epigenetic conditioning [PDF]

, 2015
Significant reductions in the extent of acute injury in the CNS can be achieved by exposure to different preconditioning stimuli, but the duration of the induced protective phenotype is typically short-lasting, and thus is deemed as limiting its clinical
Gidday, Jeffrey M
core   +3 more sources

Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm [PDF]

, 2006
Background: Hypoxic cell death follows interruption of blood supply to tissues. Although successful restoration of blood flow is mandatory for salvage of ischemic tissues, reperfusion can paradoxically place tissues at risk of further injury.
Deanfield, J.E., Loukogeorgakis, S.P., MacAllister, R.J., Panagiotido, A.T., Yellon, D.M.   +4 more
core  

Role of Forkhead Transcription Factors in Myocardial Ischemic Reperfusion Injury in Diabetes [PDF]

, 2013
Diabetes, characterized by hyperglycemia resulting from either insulin deficiency or insulin resistance, is a chronic metabolic disorder. Hearts of subjects with diabetes are more sensitive to myocardial ischemia/reperfusion injury but the underlying ...
Irwin, MG, LI, H, Li, Y, Tao, M, Xia, Z, Zhang, L   +5 more
core   +1 more source

Autonomization of Microvascular Free Flaps in Reconstructive Surgery: A Narrative Review

Microsurgery, Volume 46, Issue 2, February 2026.
ABSTRACT Background Microvascular free tissue transfer is a key technique in reconstructive surgery, enabling functional and aesthetic restoration of complex defects. While initial flap survival relies on the vascular pedicle, some flaps may become independent through a process known as autonomization, where new vascular connections form between the ...
Jonas Wüster, Leonard Knoedler, Tobias Niederegger, Leonard Simon Brandenburg, Gabriel Hundeshagen, Max Heiland, Steffen Koerdt   +6 more
wiley   +1 more source

Recanalization and reperfusion in acute ischemic stroke. [PDF]

, 2010
Revascularization remains the most intuitive strategy to reverse ischemic injury associated with arterial occlusion in acute stroke. Revascularization may lead to opening of an occluded artery, or recanalization, yet restoration of downstream flow, or ...
Liebeskind, David S
core   +2 more sources

Optimizing Donor Kidneys During Normothermic Machine Perfusion With Sevoflurane: Design of a Research Model

Artificial Organs, Volume 50, Issue 2, Page 189-199, February 2026.
A stable kidney normothermic machine perfusion model with sevoflurane delivery via a vaporizer was established, enabling mechanistic and therapeutic studies of ischemia–reperfusion injury. ABSTRACT Normothermic machine perfusion (NMP) of donor kidneys provides an opportunity not only for organ preservation but also for therapeutic intervention to ...
Philip N. Günkel, Shuqi Yang, Rozemarijn S. Tuinhout, Sebastiaan J. Luttik, Roland F. Hoffmann, Petra J. Ottens, Damien Richard, Matthieu Jabaudon, Michel M. R. F. Struys, Henri G. D. Leuvenink, Gertrude J. Nieuwenhuijs‐Moeke   +10 more
wiley   +1 more source

Acute Stress Attenuates Hepatic Ischemia–Reperfusion Injury via Hypothalamic CRH Neuron‐Induced HPA Axis Activation

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
This study demonstrates the protective effect of acute restraint stress (ARS) against hepatic ischemia–reperfusion injury (HIRI) in mice and investigates its specific neuroendocrine mechanisms. During ARS, excitability of PVNCRH neurons significantly increases, which drives HPA axis to release corticosterone, thereby reducing hepatic inflammation and ...
Xiaoqi Lin, Dan Yang, Shuyang Wang, Baoshan Wang, Ling Zhu, Yanyu Zhou, Yifei Zhou, Song Zhang, Qionghui Zhan, Yingfu Jiao, Weifeng Yu, Liqun Yang, Po Gao   +12 more
wiley   +1 more source

Postconditioning ameliorates lipid peroxidation in liver ischemia-reperfusion injury in rats Pós-condicionamento melhora a peroxidação lipídica na lesão de isquemia-reperfusão hepática em ratos

Acta Cirúrgica Brasileira, 2009
PURPOSE: Liver ischemia-reperfusion injury is a phenomenon presents in events like liver resections and transplantation. The restoration of blood flow may leads to local and systemic injury.
Antonio Roberto Franchi Teixeira, Nilza T. Molan, Márcia Saldanha Kubrusly, Marta Bellodi-Privato, Ana Maria Coelho, Kátia R. Leite, Marcel Autran Cesar Machado, Telésforo Bacchella, Marcel Cerqueira César Machado   +8 more
doaj   +1 more source

Protective Effect of Delayed Ischemic Postconditioning on Embolic Stroke Complications in Female Rat [PDF]

Journal of Kerman University of Medical Sciences, 2014
Background & Aims: Ischemic postconditioning, conducted by a series of brief occlusion and release of the bilateral common carotid arteries, has neuroprotective properties in permanent or transient models of middle cerebral artery (MCA) occlusion but its
M Mobini, H Rezazadeh, A Shamsizadeh, V Ehsani, E Hakimizadeh, S Amir-Esmaili, M Allahtavakoli   +6 more
doaj  

Effect of remote ischemic conditioning on atrial fibrillation and outcome after coronary artery bypass grafting (RICO-trial)

BMC Anesthesiology, 2011
Background Pre- and postconditioning describe mechanisms whereby short ischemic periods protect an organ against a longer period of ischemia. Interestingly, short ischemic periods of a limb, in itself harmless, may increase the ischemia tolerance of ...
Wouters Patrick, Momeni Mona, Driessen Antoine HG, de Mol Bas AJM, de Groot Joris R, Dijkgraaf Marcel GW, Weber Nina C, Schlack Wolfgang S, Tolenaar Noortje, de Bruin Anton, Heijnen Bram GADH, van Dongen Eric HPA, De Hert Stefan G, Hollmann Markus W, Brevoord Daniel, Bouchez Stefaan, Hofland Jan, Lüthen Christan, Meijer-Treschan Tanja A, Pannen Benedikt H, Preckel Benedikt   +20 more
doaj   +1 more source