Results 61 to 70 of about 3,281 (176)

Limb remote ischemic postconditioning protects integrity of the blood-brain barrier after stroke

Neural Regeneration Research, 2018
Integrity of the blood-brain barrier structure is essential for maintaining the internal environment of the brain. Development of cerebral infarction and brain edema is strongly associated with blood-brain barrier leakage.
Juan Li, Xiao-Song Hu, Fang-Fang Zhou, Shuai Li, You-Sheng Lin, Wen-Qian Qi, Cun-Fang Qi, Xiao Zhang   +7 more
doaj   +1 more source

Impact of bicarbonate on ionized calcium and cardiac function in albumin‐free Langendorff perfusion in hearts of male rats

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract The adult Langendorff methodology lacks standardization, with inconsistencies in the pH and calcium concentrations of Krebs–Henseleit (K‐H) solution. The aim of this study was to clarify these inconsistencies. Adult male Wistar rat hearts were subjected to 40 or 80 min of global ischemia followed by reperfusion.
Jan Doul, Zuzana Charvátová, Martin Modrák, David Kala, Jakub Otáhal   +4 more
wiley   +1 more source

Ischemic Postconditioning Protects Neuronal Death Caused by Cerebral Ischemia and Reperfusion via Attenuating Protein Aggregation

International Journal of Medical Sciences, 2012
Objective: To investigate the effect of ischemic postconditioning on protein aggregation caused by transient ischemia and reperfusion and to clarify its underlying mechanism.Methods: Two-vessel-occluded transient global ischemia rat model was used.
Jianmin Liang, Jihang Yao, Guangming Wang, Ying Wang, Boyu Wang, Pengfei Ge
doaj  

Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options

Frontiers in Neurology, 2018
Novel and innovative approaches are essential in developing new treatments and improving clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a series of mechanical interruptions in blood flow of a distal organ ...
Gangling Chen, Gangling Chen, Mrugesh Thakkar, Christopher Robinson, Christopher Robinson, Sylvain Doré, Sylvain Doré, Sylvain Doré, Sylvain Doré, Sylvain Doré, Sylvain Doré, Sylvain Doré   +11 more
doaj   +1 more source

Sevoflurane postconditioning improves spatial learning and memory ability involving mitochondrial permeability transition pore in hemorrhagic shock and resuscitation rats

Brain and Behavior, 2020
Background Hemorrhagic shock induces the cognitive deficiency. Sevoflurane postconditioning has been documented to provide neuroprotection against ischemic–reperfusion injury by suppressing apoptosis.
Li Zhang, Li Huang, Jingxian Wang, Muchun Zhang, Ye Zhang, Xianwen Hu   +5 more
doaj   +1 more source

Ischemic Postconditioning Assessment in the Liver of Rats Undergoing Mesenteric Ischemia and Reperfusion

Brazilian Journal of Cardiovascular Surgery
Introduction: Ischemic postconditioning is a method that shows evidence of efficacy in minimizing reperfusion injury; however, its effectiveness in preventing injuries in distant organs is still unknown, especially in those who have undergone mesenteric ...
Carlos Henrique Marques dos Santos, Ricardo Dutra Aydos, Ed Nogueira Neto, Luciana Nakao Odashiro Miiji, Pedro Carvalho Cassino, Isadora Ishaq Alves, Nádia Meneguesso Calheiros, Milena Garcia   +7 more
doaj   +1 more source

Could limb laterality influence the efficacy of remote postischemic conditioning after stroke?

Neuroprotection, Volume 4, Issue 3, Page 195-198, September 2026.
Hansen Chen, Gary K. Steinberg
wiley   +1 more source

Imperatorin ameliorates myocardial ischemia‐reperfusion injury by inhibiting endoplasmic reticulum stress‐mediated apoptosis via the PI3K/AKT/Nrf2 pathway

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
By activating the PI3K/AKT/Nrf2 pathway, imperatorin can reduce endoplasmic reticulum stress and its mediated apoptosis in cardiomyocytes, improve the pathological changes of myocardial tissue, and thus improve myocardial ischemia/reperfusion injury.
Mingjun Han, Fan Yu, Huanhuan Li
wiley   +1 more source

Effect of postconditioning and atorvastatin in preventing remote intestinal reperfusion injury

Journal of Coloproctology, 2017
Objective: To evaluate the capacity of ischemic postconditioning and atorvastatin in prevent or minimize reperfusion injury in small bowel of rats subjected to ischemia and reperfusion by abdominal aorta clamping.
Carlos Henrique Marques dos Santos, Doroty Mesquita Dourado, Trícia Luna Sampaio, Letícia do Espirito Santo Dias, Murillo Henrique Martins de Almeida, João Victor Durães Gomes Oliva, Ian de Oliveira Chaves, Henrique Budib Dorsa Pontes   +7 more
doaj   +1 more source

HIF‐1α/Netrin‐4 Axis Mediates RIPC‐Induced Angiogenesis and Neurogenesis After Ischemic Stroke

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Remote ischemic postconditioning (RIPC) confers neuroprotection in ischemic stroke partly via promoting angiogenesis and neurogenesis, but its precise molecular mechanisms remain unclear; here, we investigated the role of the secreted guidance protein Netrin‐4 (NTN4) and its upstream regulator hypoxia‐inducible factor 1α (HIF‐1α) in mediating ...
Zhaowei Feng, Zhenqian Liu, Siyu Tang, Meihua Pan, Kaishen Zhu, Yiwei Liu, Chunyu Wang, Ruiqin Yao, Xiue Wei, Haiyan Liu   +9 more
wiley   +1 more source